FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023490849> ?p ?o ?g. }

• W2023490849 endingPage "272" @default.
• W2023490849 startingPage "258" @default.
• W2023490849 abstract "Glutamate is the main excitatory neurotransmitter in the nervous system, including in primary afferent neurons. However, to date a glutamatergic phenotype of autonomic neurons has not been described. Therefore, we explored the expression of vesicular glutamate transporter (VGLUT) types 1, 2 and 3 in lumbar sympathetic chain (LSC) and major pelvic ganglion (MPG) of naïve BALB/C mice, as well as after pelvic nerve axotomy (PNA), using immunohistochemistry and in situ hybridization. Colocalization with activating transcription factor-3 (ATF-3), tyrosine hydroxylase (TH), vesicular acetylcholine transporter (VAChT) and calcitonin gene-related peptide was also examined. Sham-PNA, sciatic nerve axotomy (SNA) or naïve mice were included. In naïve mice, VGLUT(2)-like immunoreactivity (LI) was only detected in fibers and varicosities in LSC and MPG; no ATF-3-immunoreactive (IR) neurons were visible. In contrast, PNA induced upregulation of VGLUT(2) protein and transcript, as well as of ATF-3-LI in subpopulations of LSC neurons. Interestingly, VGLUT(2)-IR LSC neurons coexpressed ATF-3, and often lacked the noradrenergic marker TH. SNA only increased VGLUT(2) protein and transcript in scattered LSC neurons. Neither PNA nor SNA upregulated VGLUT(2) in MPG neurons. We also found perineuronal baskets immunoreactive either for VGLUT(2) or the acetylcholinergic marker VAChT in non-PNA MPGs, usually around TH-IR neurons. VGLUT(1)-LI was restricted to some varicosities in MPGs, was absent in LSCs, and remained largely unaffected by PNA or SNA. This was confirmed by the lack of expression of VGLUT(1) or VGLUT(3) mRNAs in LSCs, even after PNA or SNA. Taken together, axotomy of visceral and non-visceral nerves results in a glutamatergic phenotype of some LSC neurons. In addition, we show previously non-described MPG perineuronal glutamatergic baskets." @default.
• W2023490849 created "2016-06-24" @default.
• W2023490849 creator A5004410871 @default.
• W2023490849 creator A5017811687 @default.
• W2023490849 creator A5047439852 @default.
• W2023490849 creator A5047846623 @default.
• W2023490849 creator A5064479411 @default.
• W2023490849 creator A5077494149 @default.
• W2023490849 date "2011-08-01" @default.
• W2023490849 modified "2023-10-03" @default.
• W2023490849 title "Some lumbar sympathetic neurons develop a glutamatergic phenotype after peripheral axotomy with a note on VGLUT2-positive perineuronal baskets" @default.
• W2023490849 cites W1503017204 @default.
• W2023490849 cites W1505743813 @default.
• W2023490849 cites W1529080374 @default.
• W2023490849 cites W1558960310 @default.
• W2023490849 cites W1586892645 @default.
• W2023490849 cites W1679749381 @default.
• W2023490849 cites W1831515958 @default.
• W2023490849 cites W1963502721 @default.
• W2023490849 cites W1965568067 @default.
• W2023490849 cites W1968925924 @default.
• W2023490849 cites W1969591746 @default.
• W2023490849 cites W1974940638 @default.
• W2023490849 cites W1976457158 @default.
• W2023490849 cites W1978257242 @default.
• W2023490849 cites W1979136169 @default.
• W2023490849 cites W1984761877 @default.
• W2023490849 cites W1987473642 @default.
• W2023490849 cites W1988054281 @default.
• W2023490849 cites W1989138350 @default.
• W2023490849 cites W1989609722 @default.
• W2023490849 cites W1990442137 @default.
• W2023490849 cites W1992960260 @default.
• W2023490849 cites W1993602125 @default.
• W2023490849 cites W1995103567 @default.
• W2023490849 cites W1996586958 @default.
• W2023490849 cites W1999163588 @default.
• W2023490849 cites W1999948332 @default.
• W2023490849 cites W2001341182 @default.
• W2023490849 cites W2001803470 @default.
• W2023490849 cites W2002397995 @default.
• W2023490849 cites W2003572485 @default.
• W2023490849 cites W2004030558 @default.
• W2023490849 cites W2005078212 @default.
• W2023490849 cites W2006224782 @default.
• W2023490849 cites W2009314975 @default.
• W2023490849 cites W2012819403 @default.
• W2023490849 cites W2015245748 @default.
• W2023490849 cites W2015280063 @default.
• W2023490849 cites W2015470781 @default.
• W2023490849 cites W2016597947 @default.
• W2023490849 cites W2017357594 @default.
• W2023490849 cites W2021158519 @default.
• W2023490849 cites W2021559851 @default.
• W2023490849 cites W2022494272 @default.
• W2023490849 cites W2022925201 @default.
• W2023490849 cites W2026403500 @default.
• W2023490849 cites W2028536961 @default.
• W2023490849 cites W2029277864 @default.
• W2023490849 cites W2030541760 @default.
• W2023490849 cites W2031885265 @default.
• W2023490849 cites W2033188828 @default.
• W2023490849 cites W2036183103 @default.
• W2023490849 cites W2038825302 @default.
• W2023490849 cites W2045268238 @default.
• W2023490849 cites W2046426313 @default.
• W2023490849 cites W2048404196 @default.
• W2023490849 cites W2049486069 @default.
• W2023490849 cites W2050123488 @default.
• W2023490849 cites W2050279035 @default.
• W2023490849 cites W2051687929 @default.
• W2023490849 cites W2057124372 @default.
• W2023490849 cites W2058020736 @default.
• W2023490849 cites W2059864937 @default.
• W2023490849 cites W2064348349 @default.
• W2023490849 cites W2064782135 @default.
• W2023490849 cites W2065874844 @default.
• W2023490849 cites W2068037530 @default.
• W2023490849 cites W2068401230 @default.
• W2023490849 cites W2068403477 @default.
• W2023490849 cites W2068541684 @default.
• W2023490849 cites W2068614699 @default.
• W2023490849 cites W2068968489 @default.
• W2023490849 cites W2071666600 @default.
• W2023490849 cites W2075449089 @default.
• W2023490849 cites W2078187429 @default.
• W2023490849 cites W2080270903 @default.
• W2023490849 cites W2082612712 @default.
• W2023490849 cites W2083787933 @default.
• W2023490849 cites W2086142300 @default.
• W2023490849 cites W2088622454 @default.
• W2023490849 cites W2089543365 @default.
• W2023490849 cites W2090305787 @default.
• W2023490849 cites W2090389679 @default.
• W2023490849 cites W2095397861 @default.
• W2023490849 cites W2099375566 @default.
• W2023490849 cites W2099863319 @default.
• W2023490849 cites W2108908759 @default.

• next