FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023491353> ?p ?o ?g. }

• W2023491353 endingPage "376" @default.
• W2023491353 startingPage "366" @default.
• W2023491353 abstract "Genetic risk factors for chronic kidney disease (CKD) are being identified through international collaborations. By comparison, epigenetic risk factors for CKD have only recently been considered using population-based approaches. DNA methylation is a major epigenetic modification that is associated with complex diseases, so we investigated methylome-wide loci for association with CKD. A total of 485,577 unique features were evaluated in 255 individuals with CKD (cases) and 152 individuals without evidence of renal disease (controls). Following stringent quality control, raw data were quantile normalized and β values calculated to reflect the methylation status at each site. The difference in methylation status was evaluated between cases and controls with resultant P values adjusted for multiple testing. Genes with significantly increased and decreased levels of DNA methylation were considered for biological relevance by functional enrichment analysis using KEGG pathways in Partek Genomics Suite. Twenty-three genes, where more than one CpG per loci was identified with Padjusted < 10−8, demonstrated significant methylation changes associated with CKD and additional support for these associated loci was sought from published literature. Strong biological candidates for CKD that showed statistically significant differential methylation include CUX1, ELMO1, FKBP5, INHBA-AS1, PTPRN2, and PRKAG2 genes; several genes are differentially methylated in kidney tissue and RNA-seq supports a functional role for differential methylation in ELMO1 and PRKAG2 genes. This study reports the largest, most comprehensive, genome-wide quantitative evaluation of DNA methylation for association with CKD. Evidence confirming methylation sites influence development of CKD would stimulate research to identify epigenetic therapies that might be clinically useful for CKD." @default.
• W2023491353 created "2016-06-24" @default.
• W2023491353 creator A5020682446 @default.
• W2023491353 creator A5023452243 @default.
• W2023491353 creator A5037199781 @default.
• W2023491353 creator A5067092840 @default.
• W2023491353 date "2013-11-19" @default.
• W2023491353 modified "2023-10-10" @default.
• W2023491353 title "DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney disease" @default.
• W2023491353 cites W1546952499 @default.
• W2023491353 cites W1547036516 @default.
• W2023491353 cites W1967180093 @default.
• W2023491353 cites W1967693436 @default.
• W2023491353 cites W1976081689 @default.
• W2023491353 cites W1982977832 @default.
• W2023491353 cites W1987197959 @default.
• W2023491353 cites W1988893071 @default.
• W2023491353 cites W1997824331 @default.
• W2023491353 cites W1999615433 @default.
• W2023491353 cites W2001589707 @default.
• W2023491353 cites W2002431639 @default.
• W2023491353 cites W2003535733 @default.
• W2023491353 cites W2006207922 @default.
• W2023491353 cites W2011988545 @default.
• W2023491353 cites W2012322300 @default.
• W2023491353 cites W2018901137 @default.
• W2023491353 cites W2029033394 @default.
• W2023491353 cites W2031807034 @default.
• W2023491353 cites W2034165907 @default.
• W2023491353 cites W2036194871 @default.
• W2023491353 cites W2036632755 @default.
• W2023491353 cites W2039669402 @default.
• W2023491353 cites W2044695864 @default.
• W2023491353 cites W2050074594 @default.
• W2023491353 cites W2050593481 @default.
• W2023491353 cites W2051610146 @default.
• W2023491353 cites W2053102671 @default.
• W2023491353 cites W2054601158 @default.
• W2023491353 cites W2058261392 @default.
• W2023491353 cites W2058542660 @default.
• W2023491353 cites W2060971778 @default.
• W2023491353 cites W2063369009 @default.
• W2023491353 cites W2064228323 @default.
• W2023491353 cites W2066312038 @default.
• W2023491353 cites W2073546855 @default.
• W2023491353 cites W2081219006 @default.
• W2023491353 cites W2082127519 @default.
• W2023491353 cites W2083957244 @default.
• W2023491353 cites W2084270956 @default.
• W2023491353 cites W2086892564 @default.
• W2023491353 cites W2091503140 @default.
• W2023491353 cites W2098540300 @default.
• W2023491353 cites W2099739381 @default.
• W2023491353 cites W2105008689 @default.
• W2023491353 cites W2105924489 @default.
• W2023491353 cites W2106610064 @default.
• W2023491353 cites W2111399340 @default.
• W2023491353 cites W2118210161 @default.
• W2023491353 cites W2118995736 @default.
• W2023491353 cites W2119443108 @default.
• W2023491353 cites W2125065061 @default.
• W2023491353 cites W2129963016 @default.
• W2023491353 cites W2130816592 @default.
• W2023491353 cites W2131261706 @default.
• W2023491353 cites W2149833810 @default.
• W2023491353 cites W2150250444 @default.
• W2023491353 cites W2155360559 @default.
• W2023491353 cites W2163381378 @default.
• W2023491353 cites W2165019590 @default.
• W2023491353 cites W2165463320 @default.
• W2023491353 cites W2169314667 @default.
• W2023491353 cites W2169556367 @default.
• W2023491353 cites W2325094346 @default.
• W2023491353 cites W2329888282 @default.
• W2023491353 cites W2975921742 @default.
• W2023491353 cites W325121657 @default.
• W2023491353 cites W4211214771 @default.
• W2023491353 cites W4230784961 @default.
• W2023491353 doi "https://doi.org/10.4161/epi.27161" @default.
• W2023491353 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4053455" @default.
• W2023491353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24253112" @default.
• W2023491353 hasPublicationYear "2013" @default.
• W2023491353 type Work @default.
• W2023491353 sameAs 2023491353 @default.
• W2023491353 citedByCount "133" @default.
• W2023491353 countsByYear W20234913532014 @default.
• W2023491353 countsByYear W20234913532015 @default.
• W2023491353 countsByYear W20234913532016 @default.
• W2023491353 countsByYear W20234913532017 @default.
• W2023491353 countsByYear W20234913532018 @default.
• W2023491353 countsByYear W20234913532019 @default.
• W2023491353 countsByYear W20234913532020 @default.
• W2023491353 countsByYear W20234913532021 @default.
• W2023491353 countsByYear W20234913532022 @default.
• W2023491353 countsByYear W20234913532023 @default.
• W2023491353 crossrefType "journal-article" @default.
• W2023491353 hasAuthorship W2023491353A5020682446 @default.
• W2023491353 hasAuthorship W2023491353A5023452243 @default.

• next