FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023492181> ?p ?o ?g. }

• W2023492181 endingPage "330" @default.
• W2023492181 startingPage "323" @default.
• W2023492181 abstract "Isolated spinal cords of newborn rats were perfused with artificial cerebrospinal fluid and the effects of substance P and its analogs on the release of endogenous GABA were examined. Application of substance P evoked a dose-dependent release of GABA from spinal cords. The threshold concentration of substance P for induction of a significant increase in the GABA release was 3μM. The substance P-evoked GABA release was neither blocked by removal of Ca2+ from perfusion medium nor by tetrodotoxin. In contrast, the GABA release evoked by high K+ (90 mM) was abolished in Ca2+ -free medium, and the GABA release evoked by veratridine (5μM) was suppressed by tetrodotoxin (1 μM). A GABA uptake inhibitor, cis-4-hydroxynipecotic acid, markedly augmented the GABA release induced by high K+, but not that induced by substance P or veratridine. These results suggest the possibility that a carrier-mediated mechanism might be involved in the GABA release induced by substance P, as well as by veratridine, in the newborn rat spinal cord. Two N-terminal fragments of substance P, substance P free acid and substance P1–10 amide, as well as [d-Arg1,d-Trp7,9,Leu11]substance P (spantide), evoked an increase in the GABA release, whereas substance P1–6 and a C-terminal fragment, substance P5–11 were inactive. Somatostatin and compound 48/80 also evoked a GABA release, which was independent of external Ca2+ and resistant to tetrodotoxin. [d-Pro4,d-Trp7,9,10]substance P4–11 (10–15 μM) inhibited the GABA release evoked by substance P, somatostatin and compound 48/80. These results showed that the features of the GABA release evoked by substance P, somatostatin and compound 48/80 from the neonatal rat spinal cord are similar to those of the histamine release evoked by these compounds from mast cells and suggest the involvement of a similar or the same mechanism in the releases from two tissues." @default.
• W2023492181 created "2016-06-24" @default.
• W2023492181 creator A5014314344 @default.
• W2023492181 creator A5017960488 @default.
• W2023492181 creator A5039974288 @default.
• W2023492181 creator A5057367513 @default.
• W2023492181 creator A5058086052 @default.
• W2023492181 creator A5080088081 @default.
• W2023492181 creator A5086525882 @default.
• W2023492181 date "1991-01-01" @default.
• W2023492181 modified "2023-09-30" @default.
• W2023492181 title "Substance P-Evoked release of GABA from isolated spinal cord of the newborn rat" @default.
• W2023492181 cites W1967024745 @default.
• W2023492181 cites W1971062901 @default.
• W2023492181 cites W1972416469 @default.
• W2023492181 cites W1978079806 @default.
• W2023492181 cites W1978934258 @default.
• W2023492181 cites W1982770942 @default.
• W2023492181 cites W1984091029 @default.
• W2023492181 cites W1990673766 @default.
• W2023492181 cites W1992434273 @default.
• W2023492181 cites W2000711169 @default.
• W2023492181 cites W2003983701 @default.
• W2023492181 cites W2004624137 @default.
• W2023492181 cites W2006006085 @default.
• W2023492181 cites W2006242868 @default.
• W2023492181 cites W2011113908 @default.
• W2023492181 cites W2014663128 @default.
• W2023492181 cites W2023151797 @default.
• W2023492181 cites W2026447477 @default.
• W2023492181 cites W2027178000 @default.
• W2023492181 cites W2028833035 @default.
• W2023492181 cites W2029972349 @default.
• W2023492181 cites W2031203578 @default.
• W2023492181 cites W2043609818 @default.
• W2023492181 cites W2045917231 @default.
• W2023492181 cites W2055035861 @default.
• W2023492181 cites W2055628150 @default.
• W2023492181 cites W2058724157 @default.
• W2023492181 cites W2062036553 @default.
• W2023492181 cites W2064566965 @default.
• W2023492181 cites W2070868453 @default.
• W2023492181 cites W2075070069 @default.
• W2023492181 cites W2077049690 @default.
• W2023492181 cites W2081874188 @default.
• W2023492181 cites W2083036859 @default.
• W2023492181 cites W2087756960 @default.
• W2023492181 cites W2089266124 @default.
• W2023492181 cites W2107858856 @default.
• W2023492181 cites W2120174031 @default.
• W2023492181 cites W2125164441 @default.
• W2023492181 cites W2126850159 @default.
• W2023492181 cites W2163873080 @default.
• W2023492181 cites W2273258504 @default.
• W2023492181 doi "https://doi.org/10.1016/0306-4522(91)90229-h" @default.
• W2023492181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1722288" @default.
• W2023492181 hasPublicationYear "1991" @default.
• W2023492181 type Work @default.
• W2023492181 sameAs 2023492181 @default.
• W2023492181 citedByCount "31" @default.
• W2023492181 crossrefType "journal-article" @default.
• W2023492181 hasAuthorship W2023492181A5014314344 @default.
• W2023492181 hasAuthorship W2023492181A5017960488 @default.
• W2023492181 hasAuthorship W2023492181A5039974288 @default.
• W2023492181 hasAuthorship W2023492181A5057367513 @default.
• W2023492181 hasAuthorship W2023492181A5058086052 @default.
• W2023492181 hasAuthorship W2023492181A5080088081 @default.
• W2023492181 hasAuthorship W2023492181A5086525882 @default.
• W2023492181 hasConcept C118303440 @default.
• W2023492181 hasConcept C126322002 @default.
• W2023492181 hasConcept C134018914 @default.
• W2023492181 hasConcept C169760540 @default.
• W2023492181 hasConcept C170493617 @default.
• W2023492181 hasConcept C178790620 @default.
• W2023492181 hasConcept C185592680 @default.
• W2023492181 hasConcept C2776297358 @default.
• W2023492181 hasConcept C2776533618 @default.
• W2023492181 hasConcept C2776741303 @default.
• W2023492181 hasConcept C2776986425 @default.
• W2023492181 hasConcept C2780775167 @default.
• W2023492181 hasConcept C50952357 @default.
• W2023492181 hasConcept C537181965 @default.
• W2023492181 hasConcept C55493867 @default.
• W2023492181 hasConcept C71924100 @default.
• W2023492181 hasConcept C86803240 @default.
• W2023492181 hasConcept C98274493 @default.
• W2023492181 hasConceptScore W2023492181C118303440 @default.
• W2023492181 hasConceptScore W2023492181C126322002 @default.
• W2023492181 hasConceptScore W2023492181C134018914 @default.
• W2023492181 hasConceptScore W2023492181C169760540 @default.
• W2023492181 hasConceptScore W2023492181C170493617 @default.
• W2023492181 hasConceptScore W2023492181C178790620 @default.
• W2023492181 hasConceptScore W2023492181C185592680 @default.
• W2023492181 hasConceptScore W2023492181C2776297358 @default.
• W2023492181 hasConceptScore W2023492181C2776533618 @default.
• W2023492181 hasConceptScore W2023492181C2776741303 @default.
• W2023492181 hasConceptScore W2023492181C2776986425 @default.
• W2023492181 hasConceptScore W2023492181C2780775167 @default.

• next