Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023492384> ?p ?o ?g. }
- W2023492384 endingPage "926" @default.
- W2023492384 startingPage "917" @default.
- W2023492384 abstract "Eight new analogs of l-trans-epoxysuccinyl-l-leucylamido(3-methyl)butane (E-64-c) containing Phe, Tyr, Tyr(1) or Tyr(I2) in place of Leu, were synthesized and tested as inhibitors of papain, bovine spleen cathepsin B, calpain I and II from porcine red cells and porcine kidney, respectively. By use of kinetic methods, the new E-64 analogs proved to irreversibly inactivate both papain and cathepsin B via reversible enzyme-inhibitor intermediates EI. Second-order rate constants for inactivation were in the range 3500-55 100 M−1s−1 for papain and 650–105 000 M−1s−1 for cathepsin B. For the inactivation of calpain I and II they ranged between 250 and 2000 M−1s−1 and were similar to those of the known E-64-c. The effectiveness of the amino acid contained in the inhibitors tested increased in the order Tyr(I) ≈ Tyr(I2) < Tyr < Phe < Leu for papain and Phe < Tyr < Tyr(I) < Leu < Tyr(I2) for cathepsin B inactivation. Replacement of the l with the d-trans-epoxysuccinyl unit caused a 10–100-fold decrease in inhibitor potencies." @default.
- W2023492384 created "2016-06-24" @default.
- W2023492384 creator A5011348485 @default.
- W2023492384 creator A5033258672 @default.
- W2023492384 creator A5045942752 @default.
- W2023492384 creator A5048211438 @default.
- W2023492384 creator A5061191212 @default.
- W2023492384 creator A5082264379 @default.
- W2023492384 creator A5089676548 @default.
- W2023492384 date "1993-01-01" @default.
- W2023492384 modified "2023-10-14" @default.
- W2023492384 title "Iodo and diiodotyrosine epoxysuccinyl derivatives as selective inhibitors of cathepsin B" @default.
- W2023492384 cites W1486512077 @default.
- W2023492384 cites W1550877969 @default.
- W2023492384 cites W1812339273 @default.
- W2023492384 cites W1837500998 @default.
- W2023492384 cites W1845792010 @default.
- W2023492384 cites W1866750512 @default.
- W2023492384 cites W1966389657 @default.
- W2023492384 cites W1983953751 @default.
- W2023492384 cites W1991392728 @default.
- W2023492384 cites W2003702128 @default.
- W2023492384 cites W2012931700 @default.
- W2023492384 cites W2017697235 @default.
- W2023492384 cites W2020629886 @default.
- W2023492384 cites W2022569781 @default.
- W2023492384 cites W2034296548 @default.
- W2023492384 cites W2049922066 @default.
- W2023492384 cites W2050953835 @default.
- W2023492384 cites W2057059334 @default.
- W2023492384 cites W2058970168 @default.
- W2023492384 cites W2059426057 @default.
- W2023492384 cites W2062773938 @default.
- W2023492384 cites W2063387497 @default.
- W2023492384 cites W2080167075 @default.
- W2023492384 cites W2081959364 @default.
- W2023492384 cites W2084466907 @default.
- W2023492384 cites W2086704099 @default.
- W2023492384 cites W2095066895 @default.
- W2023492384 cites W2095290410 @default.
- W2023492384 cites W2103439138 @default.
- W2023492384 cites W2126656466 @default.
- W2023492384 cites W2136438527 @default.
- W2023492384 cites W2137583682 @default.
- W2023492384 cites W2280591247 @default.
- W2023492384 cites W2321633873 @default.
- W2023492384 cites W2332637814 @default.
- W2023492384 doi "https://doi.org/10.1016/0223-5234(93)90046-h" @default.
- W2023492384 hasPublicationYear "1993" @default.
- W2023492384 type Work @default.
- W2023492384 sameAs 2023492384 @default.
- W2023492384 citedByCount "9" @default.
- W2023492384 countsByYear W20234923842015 @default.
- W2023492384 countsByYear W20234923842019 @default.
- W2023492384 countsByYear W20234923842023 @default.
- W2023492384 crossrefType "journal-article" @default.
- W2023492384 hasAuthorship W2023492384A5011348485 @default.
- W2023492384 hasAuthorship W2023492384A5033258672 @default.
- W2023492384 hasAuthorship W2023492384A5045942752 @default.
- W2023492384 hasAuthorship W2023492384A5048211438 @default.
- W2023492384 hasAuthorship W2023492384A5061191212 @default.
- W2023492384 hasAuthorship W2023492384A5082264379 @default.
- W2023492384 hasAuthorship W2023492384A5089676548 @default.
- W2023492384 hasConcept C167844969 @default.
- W2023492384 hasConcept C181199279 @default.
- W2023492384 hasConcept C185592680 @default.
- W2023492384 hasConcept C2779832904 @default.
- W2023492384 hasConcept C2780034444 @default.
- W2023492384 hasConcept C28021979 @default.
- W2023492384 hasConcept C34695024 @default.
- W2023492384 hasConcept C51618164 @default.
- W2023492384 hasConcept C55493867 @default.
- W2023492384 hasConcept C71240020 @default.
- W2023492384 hasConceptScore W2023492384C167844969 @default.
- W2023492384 hasConceptScore W2023492384C181199279 @default.
- W2023492384 hasConceptScore W2023492384C185592680 @default.
- W2023492384 hasConceptScore W2023492384C2779832904 @default.
- W2023492384 hasConceptScore W2023492384C2780034444 @default.
- W2023492384 hasConceptScore W2023492384C28021979 @default.
- W2023492384 hasConceptScore W2023492384C34695024 @default.
- W2023492384 hasConceptScore W2023492384C51618164 @default.
- W2023492384 hasConceptScore W2023492384C55493867 @default.
- W2023492384 hasConceptScore W2023492384C71240020 @default.
- W2023492384 hasIssue "12" @default.
- W2023492384 hasLocation W20234923841 @default.
- W2023492384 hasOpenAccess W2023492384 @default.
- W2023492384 hasPrimaryLocation W20234923841 @default.
- W2023492384 hasRelatedWork W1837500998 @default.
- W2023492384 hasRelatedWork W1979612183 @default.
- W2023492384 hasRelatedWork W1996686686 @default.
- W2023492384 hasRelatedWork W2008290278 @default.
- W2023492384 hasRelatedWork W2020724873 @default.
- W2023492384 hasRelatedWork W2066286282 @default.
- W2023492384 hasRelatedWork W2073184979 @default.
- W2023492384 hasRelatedWork W2090772131 @default.
- W2023492384 hasRelatedWork W2131243502 @default.
- W2023492384 hasRelatedWork W2156519487 @default.
- W2023492384 hasVolume "28" @default.