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- W2023492502 abstract "Adult marrow-derived mesenchymal stem cells (MSCs) were named by me in the late 1980s, and data were published in the 1990s by our group and others (1, 2) to indicate that these cells were capable of differentiating into a number of mesenchymal phenotypes in culture. At that time, it was the dogma that only one adult stem cell could be found, the hematopoietic stem cell. We now know that there are a number of tissue- or organ-specific progenitors, including neural, cardiac, liver, epidermis, and gastrointestinal stem cells, to name the most obvious. Moreover, we now appreciate that MSCs originate in many tissues as perivascular or mural cells (pericytes) (3). Importantly, these pericytes, when detached from their blood vessel nest, become activated MSCs that secrete large amounts and a substantial array of bioactive molecules. These MSC injury site-secreted molecules have profound effects on the host’s immune system and trophic effects that serve to establish a regenerative microenvironment (4). Indeed, in searching ClinicalTrials.gov, more than 285 MSC trials were listed for a vast array of clinical symptoms and diseases. For this reason, I have suggested that the stem cell activity of these cells was relatively minor, and that MSCs should be short for “medicinal signaling cells” (5)." @default.
- W2023492502 created "2016-06-24" @default.
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- W2023492502 date "2013-02-08" @default.
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- W2023492502 title "Adult mesenchymal stem cells and the NO pathways" @default.
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- W2023492502 doi "https://doi.org/10.1073/pnas.1221406110" @default.
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