Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023492582> ?p ?o ?g. }
- W2023492582 endingPage "e40056" @default.
- W2023492582 startingPage "e40056" @default.
- W2023492582 abstract "Background Inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is being pursued as a new therapeutic approach for the treatment of obesity and metabolic syndrome. Therefore, there is an urgent need to determine the effect of 11β-HSD1 inhibitor, which suppresses glucocorticoid action, on adipose tissue inflammation. The purpose of the present study was to examine the effect of BVT.2733, a selective 11β-HSD1 inhibitor, on expression of pro-inflammatory mediators and macrophage infiltration in adipose tissue in C57BL/6J mice. Methodology/Principal Findings C57BL/6J mice were fed with a normal chow diet (NC) or high fat diet (HFD). HFD treated mice were then administrated with BVT.2733 (HFD+BVT) or vehicle (HFD) for four weeks. Mice receiving BVT.2733 treatment exhibited decreased body weight and enhanced glucose tolerance and insulin sensitivity compared to control mice. BVT.2733 also down-regulated the expression of inflammation-related genes including monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α) and the number of infiltrated macrophages within the adipose tissue in vivo. Pharmacological inhibition of 11β-HSD1 and RNA interference against 11β-HSD1 reduced the mRNA levels of MCP-1 and interleukin-6 (IL-6) in cultured J774A.1 macrophages and 3T3-L1 preadipocyte in vitro. Conclusions/Significance These results suggest that BVT.2733 treatment could not only decrease body weight and improve metabolic homeostasis, but also suppress the inflammation of adipose tissue in diet-induced obese mice. 11β-HSD1 may be a very promising therapeutic target for obesity and associated disease." @default.
- W2023492582 created "2016-06-24" @default.
- W2023492582 creator A5007641864 @default.
- W2023492582 creator A5021088140 @default.
- W2023492582 creator A5023929740 @default.
- W2023492582 creator A5032608404 @default.
- W2023492582 creator A5033505144 @default.
- W2023492582 creator A5037641310 @default.
- W2023492582 creator A5044142497 @default.
- W2023492582 creator A5056755336 @default.
- W2023492582 creator A5058978439 @default.
- W2023492582 creator A5063371871 @default.
- W2023492582 creator A5065873164 @default.
- W2023492582 creator A5070214802 @default.
- W2023492582 creator A5073255312 @default.
- W2023492582 creator A5076533682 @default.
- W2023492582 date "2012-07-02" @default.
- W2023492582 modified "2023-10-01" @default.
- W2023492582 title "BVT.2733, a Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, Attenuates Obesity and Inflammation in Diet-Induced Obese Mice" @default.
- W2023492582 cites W1978262109 @default.
- W2023492582 cites W2006108107 @default.
- W2023492582 cites W2012650972 @default.
- W2023492582 cites W2015620080 @default.
- W2023492582 cites W2021943148 @default.
- W2023492582 cites W2029954109 @default.
- W2023492582 cites W2048549610 @default.
- W2023492582 cites W2058410894 @default.
- W2023492582 cites W2063131576 @default.
- W2023492582 cites W2084415944 @default.
- W2023492582 cites W2084542824 @default.
- W2023492582 cites W2086635975 @default.
- W2023492582 cites W2088593927 @default.
- W2023492582 cites W2089783517 @default.
- W2023492582 cites W2092020543 @default.
- W2023492582 cites W2104333499 @default.
- W2023492582 cites W2108759223 @default.
- W2023492582 cites W2114899132 @default.
- W2023492582 cites W2117268230 @default.
- W2023492582 cites W2131140036 @default.
- W2023492582 cites W2145248244 @default.
- W2023492582 cites W2147155432 @default.
- W2023492582 cites W2147345837 @default.
- W2023492582 cites W2150691073 @default.
- W2023492582 cites W2150925908 @default.
- W2023492582 cites W2151335106 @default.
- W2023492582 cites W2152377123 @default.
- W2023492582 cites W2154972651 @default.
- W2023492582 cites W2156280702 @default.
- W2023492582 cites W2156597872 @default.
- W2023492582 cites W2158864146 @default.
- W2023492582 cites W2163583405 @default.
- W2023492582 cites W4238497443 @default.
- W2023492582 cites W4249727000 @default.
- W2023492582 doi "https://doi.org/10.1371/journal.pone.0040056" @default.
- W2023492582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3388048" @default.
- W2023492582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22768329" @default.
- W2023492582 hasPublicationYear "2012" @default.
- W2023492582 type Work @default.
- W2023492582 sameAs 2023492582 @default.
- W2023492582 citedByCount "33" @default.
- W2023492582 countsByYear W20234925822012 @default.
- W2023492582 countsByYear W20234925822013 @default.
- W2023492582 countsByYear W20234925822014 @default.
- W2023492582 countsByYear W20234925822015 @default.
- W2023492582 countsByYear W20234925822016 @default.
- W2023492582 countsByYear W20234925822017 @default.
- W2023492582 countsByYear W20234925822018 @default.
- W2023492582 countsByYear W20234925822020 @default.
- W2023492582 countsByYear W20234925822021 @default.
- W2023492582 countsByYear W20234925822022 @default.
- W2023492582 countsByYear W20234925822023 @default.
- W2023492582 crossrefType "journal-article" @default.
- W2023492582 hasAuthorship W2023492582A5007641864 @default.
- W2023492582 hasAuthorship W2023492582A5021088140 @default.
- W2023492582 hasAuthorship W2023492582A5023929740 @default.
- W2023492582 hasAuthorship W2023492582A5032608404 @default.
- W2023492582 hasAuthorship W2023492582A5033505144 @default.
- W2023492582 hasAuthorship W2023492582A5037641310 @default.
- W2023492582 hasAuthorship W2023492582A5044142497 @default.
- W2023492582 hasAuthorship W2023492582A5056755336 @default.
- W2023492582 hasAuthorship W2023492582A5058978439 @default.
- W2023492582 hasAuthorship W2023492582A5063371871 @default.
- W2023492582 hasAuthorship W2023492582A5065873164 @default.
- W2023492582 hasAuthorship W2023492582A5070214802 @default.
- W2023492582 hasAuthorship W2023492582A5073255312 @default.
- W2023492582 hasAuthorship W2023492582A5076533682 @default.
- W2023492582 hasBestOaLocation W20234925821 @default.
- W2023492582 hasConcept C126322002 @default.
- W2023492582 hasConcept C134018914 @default.
- W2023492582 hasConcept C171089720 @default.
- W2023492582 hasConcept C2776914184 @default.
- W2023492582 hasConcept C71924100 @default.
- W2023492582 hasConcept C86803240 @default.
- W2023492582 hasConceptScore W2023492582C126322002 @default.
- W2023492582 hasConceptScore W2023492582C134018914 @default.
- W2023492582 hasConceptScore W2023492582C171089720 @default.
- W2023492582 hasConceptScore W2023492582C2776914184 @default.
- W2023492582 hasConceptScore W2023492582C71924100 @default.