Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023493118> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2023493118 endingPage "1844" @default.
- W2023493118 startingPage "1833" @default.
- W2023493118 abstract "Previous work indicated that endothelin (ET) may be involved in the pathogenesis of myocardial ischemia, although the relative importance of the ET receptor subtypes is presently not clear. The purpose of this study was to determine the role of myocardial ET-B receptors in mediating ischemic/reperfusion damage in isolated rat hearts. Saturation binding analyses were conducted with [125l]ET-1 and [125l]lRL-1620 to assess changes in ET-A and ET-B receptor binding. Total ET receptor density (Bmax) was greater in atrial versus ventricular tissue. ET-A Bmax was 8 to 10-fold greater than ET-B Bmax. In ischemic and ischemic/reperfused atrial tissue neither the equilibrium dissociation constant (Kd) nor Bmax for ET-B receptors was changed. The ET-B receptor Kd in ischemic or ischemic/reperfused ventricular tissue was also unchanged. In ischemic ventricular tissue there was a trend towards an increased ET-B Bmax, which was accentuated after ischemia/reperfusion. No changes were found in ET-A Bmax or Kd in ischemic ventricular or atrial tissue. The physiological importance of this receptor subtype in ischemic myocardium was determined using the selective ET-B agonist, sarafotoxin S6c. In non-ischemic tissue no effect on coronary flow or function were observed with sarafotoxin S6c. Furthermore, no changes were seen in ischemic time to contracture or any of the reperfusion indexes of myocardial damage. The sarafotoxin S6c utilized was active as it inhibited [125l]ET-3 binding to ET-B receptors (Ki=0.1 nM). Thus, the pro-ischemic effect of ET-1 seems to be mediated by ET-A receptors. ET-B receptors do not appear to play a role in the pathogenesis of myocardial ischemia." @default.
- W2023493118 created "2016-06-24" @default.
- W2023493118 creator A5011014176 @default.
- W2023493118 creator A5030379197 @default.
- W2023493118 creator A5076922586 @default.
- W2023493118 creator A5081283097 @default.
- W2023493118 creator A5083565948 @default.
- W2023493118 date "1994-01-01" @default.
- W2023493118 modified "2023-10-17" @default.
- W2023493118 title "Role of endothelin receptor subtype B(ET-B) in myocardial ischemia" @default.
- W2023493118 cites W1513266031 @default.
- W2023493118 cites W18385981 @default.
- W2023493118 cites W1971003043 @default.
- W2023493118 cites W1972262110 @default.
- W2023493118 cites W1977385465 @default.
- W2023493118 cites W1983184640 @default.
- W2023493118 cites W1983649348 @default.
- W2023493118 cites W1994869298 @default.
- W2023493118 cites W2003865373 @default.
- W2023493118 cites W2004528614 @default.
- W2023493118 cites W2004889800 @default.
- W2023493118 cites W2016537650 @default.
- W2023493118 cites W2029847521 @default.
- W2023493118 cites W2047784637 @default.
- W2023493118 cites W2049792668 @default.
- W2023493118 cites W2053093319 @default.
- W2023493118 cites W2054381541 @default.
- W2023493118 cites W2054733362 @default.
- W2023493118 cites W2061118662 @default.
- W2023493118 cites W2067636590 @default.
- W2023493118 cites W2074631079 @default.
- W2023493118 cites W2076221771 @default.
- W2023493118 cites W2093655696 @default.
- W2023493118 cites W2102458554 @default.
- W2023493118 cites W2110685530 @default.
- W2023493118 cites W2140527220 @default.
- W2023493118 doi "https://doi.org/10.1016/0024-3205(94)90094-9" @default.
- W2023493118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7968263" @default.
- W2023493118 hasPublicationYear "1994" @default.
- W2023493118 type Work @default.
- W2023493118 sameAs 2023493118 @default.
- W2023493118 citedByCount "17" @default.
- W2023493118 crossrefType "journal-article" @default.
- W2023493118 hasAuthorship W2023493118A5011014176 @default.
- W2023493118 hasAuthorship W2023493118A5030379197 @default.
- W2023493118 hasAuthorship W2023493118A5076922586 @default.
- W2023493118 hasAuthorship W2023493118A5081283097 @default.
- W2023493118 hasAuthorship W2023493118A5083565948 @default.
- W2023493118 hasConcept C126322002 @default.
- W2023493118 hasConcept C134018914 @default.
- W2023493118 hasConcept C144980905 @default.
- W2023493118 hasConcept C149601957 @default.
- W2023493118 hasConcept C164705383 @default.
- W2023493118 hasConcept C170493617 @default.
- W2023493118 hasConcept C185592680 @default.
- W2023493118 hasConcept C2778938600 @default.
- W2023493118 hasConcept C541997718 @default.
- W2023493118 hasConcept C71924100 @default.
- W2023493118 hasConcept C74998103 @default.
- W2023493118 hasConceptScore W2023493118C126322002 @default.
- W2023493118 hasConceptScore W2023493118C134018914 @default.
- W2023493118 hasConceptScore W2023493118C144980905 @default.
- W2023493118 hasConceptScore W2023493118C149601957 @default.
- W2023493118 hasConceptScore W2023493118C164705383 @default.
- W2023493118 hasConceptScore W2023493118C170493617 @default.
- W2023493118 hasConceptScore W2023493118C185592680 @default.
- W2023493118 hasConceptScore W2023493118C2778938600 @default.
- W2023493118 hasConceptScore W2023493118C541997718 @default.
- W2023493118 hasConceptScore W2023493118C71924100 @default.
- W2023493118 hasConceptScore W2023493118C74998103 @default.
- W2023493118 hasIssue "23" @default.
- W2023493118 hasLocation W20234931181 @default.
- W2023493118 hasLocation W20234931182 @default.
- W2023493118 hasOpenAccess W2023493118 @default.
- W2023493118 hasPrimaryLocation W20234931181 @default.
- W2023493118 hasRelatedWork W1971613811 @default.
- W2023493118 hasRelatedWork W1983371938 @default.
- W2023493118 hasRelatedWork W1997169304 @default.
- W2023493118 hasRelatedWork W2006736256 @default.
- W2023493118 hasRelatedWork W2032437128 @default.
- W2023493118 hasRelatedWork W2095084418 @default.
- W2023493118 hasRelatedWork W2141307244 @default.
- W2023493118 hasRelatedWork W2160355439 @default.
- W2023493118 hasRelatedWork W2162471541 @default.
- W2023493118 hasRelatedWork W2393521223 @default.
- W2023493118 hasVolume "55" @default.
- W2023493118 isParatext "false" @default.
- W2023493118 isRetracted "false" @default.
- W2023493118 magId "2023493118" @default.
- W2023493118 workType "article" @default.