FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023494899> ?p ?o ?g. }

• W2023494899 endingPage "1507" @default.
• W2023494899 startingPage "1497" @default.
• W2023494899 abstract "The p57(Kip2) gene belongs to the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors and has been suggested to be a tumor suppressor gene, being inactivated in various types of human cancers. However, little is known concerning p57(Kip2) possible interplay with the apoptotic cell death machinery and its possible implication for cancer. Here, we report that selective p57(Kip2) expression sensitizes cancer cells to apoptotic agents such as cisplatin, etoposide and staurosporine (STS) via a mechanism, which does not require p57(Kip2)-mediated inhibition of CDK. Translocation of p57(Kip2) to mitochondria occurs within 20 min after STS application. In fact, p57(Kip2) primarily promotes the intrinsic apoptotic pathways, favoring Bax activation and loss of mitochondrial transmembrane potential, consequent release of cytochrome-c into cytosol, caspase-9 and caspase-3 activation. In accordance, Bcl2 overexpression or voltage-dependent anion channel (VDAC) inhibition is able to inhibit p57(Kip2) cell death promoting effect. Thus, in addition to its established function in control of proliferation, these results reveal a mechanism whereby p57(Kip2) influences the mitochondrial apoptotic cell death pathway in cancer cells." @default.
• W2023494899 created "2016-06-24" @default.
• W2023494899 creator A5015447875 @default.
• W2023494899 creator A5039714449 @default.
• W2023494899 creator A5048576431 @default.
• W2023494899 creator A5067101977 @default.
• W2023494899 date "2007-04-27" @default.
• W2023494899 modified "2023-10-14" @default.
• W2023494899 title "The cell cycle inhibitor p57Kip2 promotes cell death via the mitochondrial apoptotic pathway" @default.
• W2023494899 cites W1512072225 @default.
• W2023494899 cites W154338179 @default.
• W2023494899 cites W1554372630 @default.
• W2023494899 cites W1745634660 @default.
• W2023494899 cites W1972305847 @default.
• W2023494899 cites W1974980101 @default.
• W2023494899 cites W1979091496 @default.
• W2023494899 cites W1981353115 @default.
• W2023494899 cites W1982768428 @default.
• W2023494899 cites W1987136455 @default.
• W2023494899 cites W1996588976 @default.
• W2023494899 cites W2000093730 @default.
• W2023494899 cites W2019511770 @default.
• W2023494899 cites W2028605285 @default.
• W2023494899 cites W2028987060 @default.
• W2023494899 cites W2053747212 @default.
• W2023494899 cites W2055085859 @default.
• W2023494899 cites W2063833389 @default.
• W2023494899 cites W2094697218 @default.
• W2023494899 cites W2097056631 @default.
• W2023494899 cites W2097711594 @default.
• W2023494899 cites W2116990217 @default.
• W2023494899 cites W2127639335 @default.
• W2023494899 cites W2129115383 @default.
• W2023494899 cites W2141528632 @default.
• W2023494899 cites W2156616178 @default.
• W2023494899 cites W2164286410 @default.
• W2023494899 cites W2168665115 @default.
• W2023494899 cites W2245636408 @default.
• W2023494899 cites W2321985754 @default.
• W2023494899 cites W4243368124 @default.
• W2023494899 doi "https://doi.org/10.1038/sj.cdd.4402158" @default.
• W2023494899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17464323" @default.
• W2023494899 hasPublicationYear "2007" @default.
• W2023494899 type Work @default.
• W2023494899 sameAs 2023494899 @default.
• W2023494899 citedByCount "57" @default.
• W2023494899 countsByYear W20234948992012 @default.
• W2023494899 countsByYear W20234948992013 @default.
• W2023494899 countsByYear W20234948992014 @default.
• W2023494899 countsByYear W20234948992015 @default.
• W2023494899 countsByYear W20234948992016 @default.
• W2023494899 countsByYear W20234948992017 @default.
• W2023494899 countsByYear W20234948992018 @default.
• W2023494899 countsByYear W20234948992019 @default.
• W2023494899 countsByYear W20234948992020 @default.
• W2023494899 countsByYear W20234948992021 @default.
• W2023494899 countsByYear W20234948992022 @default.
• W2023494899 countsByYear W20234948992023 @default.
• W2023494899 crossrefType "journal-article" @default.
• W2023494899 hasAuthorship W2023494899A5015447875 @default.
• W2023494899 hasAuthorship W2023494899A5039714449 @default.
• W2023494899 hasAuthorship W2023494899A5048576431 @default.
• W2023494899 hasAuthorship W2023494899A5067101977 @default.
• W2023494899 hasBestOaLocation W20234948991 @default.
• W2023494899 hasConcept C104317684 @default.
• W2023494899 hasConcept C121608353 @default.
• W2023494899 hasConcept C124320809 @default.
• W2023494899 hasConcept C146587185 @default.
• W2023494899 hasConcept C181199279 @default.
• W2023494899 hasConcept C184235292 @default.
• W2023494899 hasConcept C185592680 @default.
• W2023494899 hasConcept C190283241 @default.
• W2023494899 hasConcept C195794163 @default.
• W2023494899 hasConcept C200784783 @default.
• W2023494899 hasConcept C2779084600 @default.
• W2023494899 hasConcept C28859421 @default.
• W2023494899 hasConcept C29537977 @default.
• W2023494899 hasConcept C31573885 @default.
• W2023494899 hasConcept C502942594 @default.
• W2023494899 hasConcept C54355233 @default.
• W2023494899 hasConcept C547475151 @default.
• W2023494899 hasConcept C55493867 @default.
• W2023494899 hasConcept C62112901 @default.
• W2023494899 hasConcept C86803240 @default.
• W2023494899 hasConcept C95444343 @default.
• W2023494899 hasConcept C96232424 @default.
• W2023494899 hasConcept C98539663 @default.
• W2023494899 hasConceptScore W2023494899C104317684 @default.
• W2023494899 hasConceptScore W2023494899C121608353 @default.
• W2023494899 hasConceptScore W2023494899C124320809 @default.
• W2023494899 hasConceptScore W2023494899C146587185 @default.
• W2023494899 hasConceptScore W2023494899C181199279 @default.
• W2023494899 hasConceptScore W2023494899C184235292 @default.
• W2023494899 hasConceptScore W2023494899C185592680 @default.
• W2023494899 hasConceptScore W2023494899C190283241 @default.
• W2023494899 hasConceptScore W2023494899C195794163 @default.
• W2023494899 hasConceptScore W2023494899C200784783 @default.
• W2023494899 hasConceptScore W2023494899C2779084600 @default.

• next