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• W2023495093 abstract "A preliminary characterization of 3-(p-chlorophenyl)-2,3-dihydro-3-hydroxythiazolo [3,2-α]-benzimidazole-2-acetic acid was conducted in mice employing tumorous and non-tumorous systems. Single doses of this chemical markedly increased the primary and secondary anti-SRBC response after optimal immunization and raised the GvH-inducing capacity of splenocytes whereas no effects were seen on the response to a T-independent antigen. Immunostimulatory doses of the drug did not modify colloidal carbon clearance, macrophage non-specific cytotoxicity towards lymphoma cells or K cell activity in the spleen. Single injections with this agent increased survival in L 1210Ha leukemia-bearing mice when administered in conjunction with irradiated tumor cells and increased anti-leukemia resistance to subsequent tumor challenges in animals primed with inactivated leukemia cells. Single drug doses 1 day after tumor transplantation exerted also a potent antimetastatic effect in the Lewis lung carcinoma system." @default.
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• W2023495093 date "1978-04-01" @default.
• W2023495093 modified "2023-09-26" @default.
• W2023495093 title "The immunostimulatory activity of 3-(p-chlorophenyl)-2,3-dihydro-3-hydroxythiazole [3, 2-α]-benzimidazole-2-acetic acid (NSC 208828)" @default.
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• W2023495093 doi "https://doi.org/10.1016/0014-2964(78)90210-4" @default.
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