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• W2023495510 abstract "The intravenous administration of LSD to young adult rabbits resulted in the disaggregation of both free and membrane-bound classes of brain polysomes. Based on the analysis of LSD dosage and the time course of the LSD-induced brain polysome shift, it was found that free polysomes were more sensitive to the drug than the membrane-bound polysome fraction. LSD-induced hyperthermia may be involved in the disaggregation of free and membrane-bound polysomes, since a correlation was found between the extent of LSD-induced hyperthermia and the degree of brain polysome shift. Prevention of LSD-induced hyperthermia by maintaining the animal at 4 degrees C blocked the disaggregation of both polysome classes. Induction of hyperthermia by elevation of ambient temperature also resulted in a shift in free and membrane-bound polysomes. In all cases the disaggregation of polysomes to monosomes was not caused by RNase activation. During polysome disaggregation, polyadenylated mRNA associated with both free and membrane-bound polysomes was not degraded but was relocalized from polysomes to monosomes." @default.
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• W2023495510 date "1981-03-01" @default.
• W2023495510 modified "2023-09-25" @default.
• W2023495510 title "Comparison of the Effect of Intravenous Administration of d-Lysergic Acid Diethylamide on Free and Membrane-Bound Polysomes in the Rabbit Brain" @default.
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• W2023495510 doi "https://doi.org/10.1111/j.1471-4159.1981.tb01721.x" @default.
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