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- W2023496777 abstract "The effect of pine leaf extract and its constituent compounds, gallic acid and galloyl gallic acid, on cell injury were determined in the cultured renal epithelial cell line, LLC-PK1.The cytotoxic effect of 3-morpholinosydnonimine (SIN-1), thought to form peroxynitrite (ONOO−) as a simultaneous superoxide (O2−) and nitric oxide (NO) generator, was inhibited by pine leaf extract, and more potently by gallic acid and galloyl gallic acid. The extract inhibited ONOO− formation by SIN-1 and scavenged ONOO− directly. Compared with the extract, gallic acid and galloyl gallic acid had potent ONOO−-scavenging activity, indicating that tannin may contribute to the activity of pine leaf extract. Both sodium nitroprusside as a NO generator and pyrogallol as an O2− generator, enhanced cytotoxicity in epithelial cells, and this effect was not abolished by the extract, gallic acid or galloyl gallic acid.The results suggest that pine leaf may exert a protective effect against ONOO−-mediated epithelial cell injury." @default.
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- W2023496777 date "1999-11-01" @default.
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- W2023496777 title "Protective Effect of Pine Leaf against Peroxynitrite-mediated Renal Epithelial Cell Injury" @default.
- W2023496777 doi "https://doi.org/10.1211/146080899128734325" @default.
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