FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023500420> ?p ?o ?g. }

• W2023500420 endingPage "50" @default.
• W2023500420 startingPage "46" @default.
• W2023500420 abstract "We tested two novel bifunctional compounds: ibuprofen-N-octyl-pyridostigmine bromide (IBU-PO) and ibuprofen-N-decyl-pyridostigmine bromide (IBU-PD). They both contain a non-steroidal anti-inflammatory drug (NSAID), ibuprofen (IBU) and pyridostigmine (PO), a cholinesterase inhibitor that acts as a cholinergic up-regulator (CURE). The two moieties are conjugated by a hydrocarbon spacer consisting of 8 (octyl) and 10 (decyl) carbons, respectively. The compounds were tested for their efficiency in reducing the neurological symptoms observed in experimental autoimmune encephalomyelitis induced in mice by myelin oligodendrocyte glycoprotein (MOG). IBU-PO and IBU-PD significantly ameliorated the clinical score (a 40-50% reduction in disease severity) over a period of 30 days, following daily administration of 1 and 0.1mg/kg, i.p., respectively. Clinical improvement was accompanied by reduced responsiveness of MOG-specific T-cells. In addition, IBU-PO and IBU-PD down-regulated the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in cultured astrocytes. To determine which moiety was responsible for these effects, we tested each of the two components, IBU and PO. Our findings indicate that combining NSAID with cholinergic intervention contributes an added therapeutic value for each distinct entity and that these bifunctional compounds act both on the peripheral immunological system and on the central nervous system (CNS) inflammatory pathways." @default.
• W2023500420 created "2016-06-24" @default.
• W2023500420 creator A5024595629 @default.
• W2023500420 creator A5026819897 @default.
• W2023500420 creator A5031772543 @default.
• W2023500420 creator A5032286057 @default.
• W2023500420 creator A5049387834 @default.
• W2023500420 date "2005-03-01" @default.
• W2023500420 modified "2023-09-25" @default.
• W2023500420 title "Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments" @default.
• W2023500420 cites W1491342058 @default.
• W2023500420 cites W1966837408 @default.
• W2023500420 cites W1989039499 @default.
• W2023500420 cites W1989172359 @default.
• W2023500420 cites W1990865742 @default.
• W2023500420 cites W1995335058 @default.
• W2023500420 cites W2049670306 @default.
• W2023500420 cites W2058332213 @default.
• W2023500420 cites W2069368135 @default.
• W2023500420 cites W2071187668 @default.
• W2023500420 cites W2072488031 @default.
• W2023500420 cites W2073295417 @default.
• W2023500420 cites W2077532810 @default.
• W2023500420 cites W2090621408 @default.
• W2023500420 cites W2173694857 @default.
• W2023500420 cites W2408817573 @default.
• W2023500420 cites W2518541454 @default.
• W2023500420 cites W4229932900 @default.
• W2023500420 cites W4238596965 @default.
• W2023500420 doi "https://doi.org/10.1016/j.neulet.2004.11.030" @default.
• W2023500420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15694272" @default.
• W2023500420 hasPublicationYear "2005" @default.
• W2023500420 type Work @default.
• W2023500420 sameAs 2023500420 @default.
• W2023500420 citedByCount "20" @default.
• W2023500420 countsByYear W20235004202012 @default.
• W2023500420 countsByYear W20235004202014 @default.
• W2023500420 countsByYear W20235004202018 @default.
• W2023500420 countsByYear W20235004202021 @default.
• W2023500420 countsByYear W20235004202023 @default.
• W2023500420 crossrefType "journal-article" @default.
• W2023500420 hasAuthorship W2023500420A5024595629 @default.
• W2023500420 hasAuthorship W2023500420A5026819897 @default.
• W2023500420 hasAuthorship W2023500420A5031772543 @default.
• W2023500420 hasAuthorship W2023500420A5032286057 @default.
• W2023500420 hasAuthorship W2023500420A5049387834 @default.
• W2023500420 hasConcept C126322002 @default.
• W2023500420 hasConcept C181199279 @default.
• W2023500420 hasConcept C185592680 @default.
• W2023500420 hasConcept C22885893 @default.
• W2023500420 hasConcept C2776914184 @default.
• W2023500420 hasConcept C2778105408 @default.
• W2023500420 hasConcept C2778486448 @default.
• W2023500420 hasConcept C2778816929 @default.
• W2023500420 hasConcept C2779357208 @default.
• W2023500420 hasConcept C2779901103 @default.
• W2023500420 hasConcept C2779944601 @default.
• W2023500420 hasConcept C2910532367 @default.
• W2023500420 hasConcept C31896038 @default.
• W2023500420 hasConcept C529278444 @default.
• W2023500420 hasConcept C55493867 @default.
• W2023500420 hasConcept C71924100 @default.
• W2023500420 hasConcept C87753298 @default.
• W2023500420 hasConcept C98274493 @default.
• W2023500420 hasConceptScore W2023500420C126322002 @default.
• W2023500420 hasConceptScore W2023500420C181199279 @default.
• W2023500420 hasConceptScore W2023500420C185592680 @default.
• W2023500420 hasConceptScore W2023500420C22885893 @default.
• W2023500420 hasConceptScore W2023500420C2776914184 @default.
• W2023500420 hasConceptScore W2023500420C2778105408 @default.
• W2023500420 hasConceptScore W2023500420C2778486448 @default.
• W2023500420 hasConceptScore W2023500420C2778816929 @default.
• W2023500420 hasConceptScore W2023500420C2779357208 @default.
• W2023500420 hasConceptScore W2023500420C2779901103 @default.
• W2023500420 hasConceptScore W2023500420C2779944601 @default.
• W2023500420 hasConceptScore W2023500420C2910532367 @default.
• W2023500420 hasConceptScore W2023500420C31896038 @default.
• W2023500420 hasConceptScore W2023500420C529278444 @default.
• W2023500420 hasConceptScore W2023500420C55493867 @default.
• W2023500420 hasConceptScore W2023500420C71924100 @default.
• W2023500420 hasConceptScore W2023500420C87753298 @default.
• W2023500420 hasConceptScore W2023500420C98274493 @default.
• W2023500420 hasIssue "1" @default.
• W2023500420 hasLocation W20235004201 @default.
• W2023500420 hasLocation W20235004202 @default.
• W2023500420 hasOpenAccess W2023500420 @default.
• W2023500420 hasPrimaryLocation W20235004201 @default.
• W2023500420 hasRelatedWork W1974896664 @default.
• W2023500420 hasRelatedWork W1999758184 @default.
• W2023500420 hasRelatedWork W2023500420 @default.
• W2023500420 hasRelatedWork W2346553461 @default.
• W2023500420 hasRelatedWork W2558090332 @default.
• W2023500420 hasRelatedWork W2624700742 @default.
• W2023500420 hasRelatedWork W314043136 @default.
• W2023500420 hasRelatedWork W4255674353 @default.
• W2023500420 hasRelatedWork W82581883 @default.
• W2023500420 hasRelatedWork W88212917 @default.
• W2023500420 hasVolume "376" @default.

• next