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- W2023502509 abstract "Testicans are proteoglycans belonging to the BM-40/SPARC/osteonectin family of extracellular calcium-binding proteins. Testican-1 is strongly expressed in the brain and has been reported to modulate neuronal attachment and matrix metalloproteinase activation. Characterization of the mouse testican-1 gene (Ticn1), consisting of 12 exons out of which exon 3 is alternatively spliced, allowed the construction of a gene targeting construct. Mice deficient in testican-1 showed no obvious morphological or behavioral abnormalities, were fertile, and had normal life spans. Despite the fact that neither of the testican-1 homologues expressed in the brain, testican-2, testican-3 and SC1/hevin, showed an increased expression in Ticn1 null mice, these results, together with those from other gene targetings, indicate extensive functional redundancy among brain proteoglycans." @default.
- W2023502509 created "2016-06-24" @default.
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- W2023502509 date "1988-01-01" @default.
- W2023502509 modified "2023-09-25" @default.
- W2023502509 title "27. Inherited and acquired bone collagen disorders (osteogenesis imperfecta and fibrogenesis imperfecta ossium)" @default.
- W2023502509 doi "https://doi.org/10.1016/8756-3282(88)90065-8" @default.
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