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• W2023502867 startingPage "1202" @default.
• W2023502867 abstract "2-[18F]Fluoro-2-deoxy-d-glucose ([18F]FDG) as the most important PET radiotracer is available in almost every PET center. However, there are only very few examples using [18F]FDG as a building block for the synthesis of 18F-labeled compounds. The present study describes the use of [18F]FDG as a building block for the synthesis of 18F-labeled peptides and proteins. [18F]FDG was converted into [18F]FDG-maleimidehexyloxime ([18F]FDG-MHO), a novel [18F]FDG-based prosthetic group for the mild and thiol group-specific 18F labeling of peptides and proteins. The reaction was performed at 100 °C for 15 min in a sealed vial containing [18F]FDG and N-(6-aminoxy-hexyl)maleimide in 80% ethanol. [18F]FDG-MHO was obtained in 45−69% radiochemical yield (based upon [18F]FDG) after HPLC purification in a total synthesis time of 45 min. Chemoselecetive conjugation of [18F]FDG-MHO to thiol groups was investigated by the reaction with the tripeptide glutathione (GSH) and the single cysteine containing protein annexin A5 (anxA5). Radiolabeled annexin A5 ([18F]FDG-MHO-anxA5) was obtained in 43−58% radiochemical yield (based upon [18F]FDG-MHO, n = 6), and [18F]FDG-MHO-anxA5 was used for a pilot small animal PET study to assess in vivo biodistribution and kinetics in a HT-29 murine xenograft model." @default.
• W2023502867 created "2016-06-24" @default.
• W2023502867 creator A5002777291 @default.
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• W2023502867 date "2008-05-16" @default.
• W2023502867 modified "2023-10-09" @default.
• W2023502867 title "Synthesis and Application of [¹⁸F]FDG-Maleimidehexyloxime ([¹⁸F]FDG-MHO): A [¹⁸F]FDG-Based Prosthetic Group for the Chemoselective ¹⁸F-Labeling of Peptides and Proteins" @default.
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• W2023502867 doi "https://doi.org/10.1021/bc8000112" @default.
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