FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023505049> ?p ?o ?g. }

• W2023505049 endingPage "169" @default.
• W2023505049 startingPage "163" @default.
• W2023505049 abstract "Both N-nitroso compounds and colonization with Helicobacter pylori represent known risk-factors for the development of gastric cancer. Endogenous formation of N-nitroso compounds is thought to occur predominantly in acidic environments such as the stomach. At neutral pH, bacteria can catalyze the formation of N-nitroso compounds. Based on experiments with a noncarcinogenic N-nitroso compound as end product, and using only a single H. pylori strain, it was recently reported that H. pylori only displays a low nitrosation capacity. As H. pylori is a highly diverse bacterial species, it is reasonable to question the generality of this finding. In this study, several genetically distinct H. pylori strains are tested for their capacity to form carcinogenic N-nitrosamines.Bacteria were grown in the presence of 0-1000 microM morpholine and nitrite (in a 1 : 1 molar ratio), at pH 7, 5 and 3.Incubation of Neisseria cinerea (positive control) with 500 microM morpholine and 500 microM nitrite, resulted in a significant increase in formation of N-nitrosomorpholine, but there was no significant induction of N-nitrosomorpholine formation by any of the H. pylori strains, at any of the three pH conditions.H. pylori does not induce formation of the carcinogenic N-nitrosomorpholine in vitro. The previously reported weak nitrosation capacity of H. pylori is not sufficient to nitrosate the more difficulty nitrosatable morpholine. This probably also holds true for other secondary amines. These results imply that the increased incidence of gastric cancer formation that is associated with gastric colonization by H. pylori is unlikely to result from the direct induced formation of carcinogenic nitrosamines by H. pylori. However, this has to be further confirmed in in vivo studies." @default.
• W2023505049 created "2016-06-24" @default.
• W2023505049 creator A5005518749 @default.
• W2023505049 creator A5010936097 @default.
• W2023505049 creator A5018186238 @default.
• W2023505049 creator A5031835687 @default.
• W2023505049 creator A5048656547 @default.
• W2023505049 creator A5054139936 @default.
• W2023505049 creator A5065921950 @default.
• W2023505049 creator A5081503066 @default.
• W2023505049 creator A5088482260 @default.
• W2023505049 date "2002-05-31" @default.
• W2023505049 modified "2023-10-18" @default.
• W2023505049 title "Helicobacter pylori does not Mediate the Formation of Carcinogenic N-Nitrosamines" @default.
• W2023505049 cites W1649485503 @default.
• W2023505049 cites W1968762409 @default.
• W2023505049 cites W1969107480 @default.
• W2023505049 cites W1972654812 @default.
• W2023505049 cites W2012936255 @default.
• W2023505049 cites W2016299826 @default.
• W2023505049 cites W2025194247 @default.
• W2023505049 cites W2033455262 @default.
• W2023505049 cites W2035478060 @default.
• W2023505049 cites W2035741549 @default.
• W2023505049 cites W2048723973 @default.
• W2023505049 cites W2051701626 @default.
• W2023505049 cites W2056611566 @default.
• W2023505049 cites W2083046728 @default.
• W2023505049 cites W2094667966 @default.
• W2023505049 cites W2109886572 @default.
• W2023505049 cites W2110132014 @default.
• W2023505049 cites W2119088209 @default.
• W2023505049 cites W2124055985 @default.
• W2023505049 cites W2125585698 @default.
• W2023505049 cites W2146087394 @default.
• W2023505049 cites W2149818671 @default.
• W2023505049 cites W2158331962 @default.
• W2023505049 cites W2169399661 @default.
• W2023505049 cites W2169825589 @default.
• W2023505049 cites W4242403342 @default.
• W2023505049 cites W79525737 @default.
• W2023505049 doi "https://doi.org/10.1046/j.1523-5378.2002.00076.x" @default.
• W2023505049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12047321" @default.
• W2023505049 hasPublicationYear "2002" @default.
• W2023505049 type Work @default.
• W2023505049 sameAs 2023505049 @default.
• W2023505049 citedByCount "13" @default.
• W2023505049 countsByYear W20235050492013 @default.
• W2023505049 countsByYear W20235050492017 @default.
• W2023505049 countsByYear W20235050492023 @default.
• W2023505049 crossrefType "journal-article" @default.
• W2023505049 hasAuthorship W2023505049A5005518749 @default.
• W2023505049 hasAuthorship W2023505049A5010936097 @default.
• W2023505049 hasAuthorship W2023505049A5018186238 @default.
• W2023505049 hasAuthorship W2023505049A5031835687 @default.
• W2023505049 hasAuthorship W2023505049A5048656547 @default.
• W2023505049 hasAuthorship W2023505049A5054139936 @default.
• W2023505049 hasAuthorship W2023505049A5065921950 @default.
• W2023505049 hasAuthorship W2023505049A5081503066 @default.
• W2023505049 hasAuthorship W2023505049A5088482260 @default.
• W2023505049 hasConcept C104882015 @default.
• W2023505049 hasConcept C114246631 @default.
• W2023505049 hasConcept C155647269 @default.
• W2023505049 hasConcept C178790620 @default.
• W2023505049 hasConcept C185592680 @default.
• W2023505049 hasConcept C2776179834 @default.
• W2023505049 hasConcept C2776384668 @default.
• W2023505049 hasConcept C2776409635 @default.
• W2023505049 hasConcept C2777395278 @default.
• W2023505049 hasConcept C2781056017 @default.
• W2023505049 hasConcept C2909807293 @default.
• W2023505049 hasConcept C523546767 @default.
• W2023505049 hasConcept C54355233 @default.
• W2023505049 hasConcept C55493867 @default.
• W2023505049 hasConcept C86803240 @default.
• W2023505049 hasConcept C89423630 @default.
• W2023505049 hasConceptScore W2023505049C104882015 @default.
• W2023505049 hasConceptScore W2023505049C114246631 @default.
• W2023505049 hasConceptScore W2023505049C155647269 @default.
• W2023505049 hasConceptScore W2023505049C178790620 @default.
• W2023505049 hasConceptScore W2023505049C185592680 @default.
• W2023505049 hasConceptScore W2023505049C2776179834 @default.
• W2023505049 hasConceptScore W2023505049C2776384668 @default.
• W2023505049 hasConceptScore W2023505049C2776409635 @default.
• W2023505049 hasConceptScore W2023505049C2777395278 @default.
• W2023505049 hasConceptScore W2023505049C2781056017 @default.
• W2023505049 hasConceptScore W2023505049C2909807293 @default.
• W2023505049 hasConceptScore W2023505049C523546767 @default.
• W2023505049 hasConceptScore W2023505049C54355233 @default.
• W2023505049 hasConceptScore W2023505049C55493867 @default.
• W2023505049 hasConceptScore W2023505049C86803240 @default.
• W2023505049 hasConceptScore W2023505049C89423630 @default.
• W2023505049 hasIssue "3" @default.
• W2023505049 hasLocation W20235050491 @default.
• W2023505049 hasLocation W20235050492 @default.
• W2023505049 hasOpenAccess W2023505049 @default.
• W2023505049 hasPrimaryLocation W20235050491 @default.
• W2023505049 hasRelatedWork W1593047912 @default.

• next