FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023505847> ?p ?o ?g. }

• W2023505847 endingPage "2574" @default.
• W2023505847 startingPage "2567" @default.
• W2023505847 abstract "Abstract hBVR functions in the cell as a reductase and as a kinase. In the first capacity, it reduces biliverdin, the product of HO activity, to the effective intracellular antioxidant, bilirubin; as a dual‐specificity kinase (S/T/Y) it activates the MAPK and IGF/IRK receptor signal transduction pathways. NF‐κB and the MAPK pathway are activated by ROS, which results in the activation of stress‐inducible genes, including ho‐1. Presently, we report on the negative effect of biliverdin on NF‐κB activation and the converse effect of hBVR. Biliverdin, in a concentration‐ and time‐dependent manner, inhibited transcriptional activity of NF‐κB in HEK293A cells. Nuclear extracts from biliverdin‐treated cells show reduced DNA binding of NF‐κB in an electromobility shift assay, whereas extracts from cells treated with TNF‐α showed enhanced binding. Coimmunoprecipitation data show hBVR binds to the 65 kDa subunit of NF‐κB, and that this is dependent on activation by TNF‐α. Overexpression of hBVR enhanced both the basal and TNF‐α‐mediated activation of NF‐κB and also that of the NF‐κB‐activated iNOS gene. Also, overexpression of hBVR arrested the cell cycle in the G 1 / G 0 phase and reduced the number of cells in S phase. Similar results were observed with MCF‐7 cells. Because of the Janus nature of NF‐κB activity in the cell and the inhibitory action of biliverdin, the present findings provide a foundation for therapeutic intervention in inflammatory diseases and cancer that may be attained by preventing reduction of biliverdin. On the other hand, by increasing BVR levels beneficial functions of NF‐κB might be augmented. © 2007 Wiley‐Liss, Inc." @default.
• W2023505847 created "2016-06-24" @default.
• W2023505847 creator A5001051903 @default.
• W2023505847 creator A5047478386 @default.
• W2023505847 date "2007-08-07" @default.
• W2023505847 modified "2023-10-15" @default.
• W2023505847 title "Biliverdin inhibits activation of NF-κB: Reversal of inhibition by human biliverdin reductase" @default.
• W2023505847 cites W1483070973 @default.
• W2023505847 cites W1497013369 @default.
• W2023505847 cites W1533671266 @default.
• W2023505847 cites W1533677192 @default.
• W2023505847 cites W1535444616 @default.
• W2023505847 cites W1563771052 @default.
• W2023505847 cites W1680009429 @default.
• W2023505847 cites W1862027433 @default.
• W2023505847 cites W1935479846 @default.
• W2023505847 cites W1967265444 @default.
• W2023505847 cites W1973081785 @default.
• W2023505847 cites W1973320894 @default.
• W2023505847 cites W1975124499 @default.
• W2023505847 cites W1983339726 @default.
• W2023505847 cites W1984775683 @default.
• W2023505847 cites W1988130146 @default.
• W2023505847 cites W1989227773 @default.
• W2023505847 cites W1989986502 @default.
• W2023505847 cites W1990834361 @default.
• W2023505847 cites W1993354784 @default.
• W2023505847 cites W1997901849 @default.
• W2023505847 cites W2000426321 @default.
• W2023505847 cites W2002261958 @default.
• W2023505847 cites W2002874458 @default.
• W2023505847 cites W2007789422 @default.
• W2023505847 cites W2016847790 @default.
• W2023505847 cites W2029868256 @default.
• W2023505847 cites W2030360716 @default.
• W2023505847 cites W2033083444 @default.
• W2023505847 cites W2036224418 @default.
• W2023505847 cites W2036285327 @default.
• W2023505847 cites W2048646132 @default.
• W2023505847 cites W2056875662 @default.
• W2023505847 cites W2059625939 @default.
• W2023505847 cites W2065527303 @default.
• W2023505847 cites W2071307185 @default.
• W2023505847 cites W2077929263 @default.
• W2023505847 cites W2078609739 @default.
• W2023505847 cites W2079697817 @default.
• W2023505847 cites W2079822311 @default.
• W2023505847 cites W2081778725 @default.
• W2023505847 cites W2084241456 @default.
• W2023505847 cites W2087044010 @default.
• W2023505847 cites W2088237849 @default.
• W2023505847 cites W2093057466 @default.
• W2023505847 cites W2095325220 @default.
• W2023505847 cites W2097732899 @default.
• W2023505847 cites W2105729793 @default.
• W2023505847 cites W2124076790 @default.
• W2023505847 cites W2124163811 @default.
• W2023505847 cites W2128702794 @default.
• W2023505847 cites W2129535784 @default.
• W2023505847 cites W2140889728 @default.
• W2023505847 cites W2141710909 @default.
• W2023505847 cites W2145028653 @default.
• W2023505847 cites W2145530136 @default.
• W2023505847 cites W2145989829 @default.
• W2023505847 cites W2171885946 @default.
• W2023505847 doi "https://doi.org/10.1002/ijc.22978" @default.
• W2023505847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17683071" @default.
• W2023505847 hasPublicationYear "2007" @default.
• W2023505847 type Work @default.
• W2023505847 sameAs 2023505847 @default.
• W2023505847 citedByCount "67" @default.
• W2023505847 countsByYear W20235058472012 @default.
• W2023505847 countsByYear W20235058472013 @default.
• W2023505847 countsByYear W20235058472014 @default.
• W2023505847 countsByYear W20235058472015 @default.
• W2023505847 countsByYear W20235058472016 @default.
• W2023505847 countsByYear W20235058472017 @default.
• W2023505847 countsByYear W20235058472019 @default.
• W2023505847 countsByYear W20235058472020 @default.
• W2023505847 countsByYear W20235058472021 @default.
• W2023505847 countsByYear W20235058472022 @default.
• W2023505847 crossrefType "journal-article" @default.
• W2023505847 hasAuthorship W2023505847A5001051903 @default.
• W2023505847 hasAuthorship W2023505847A5047478386 @default.
• W2023505847 hasBestOaLocation W20235058471 @default.
• W2023505847 hasConcept C181199279 @default.
• W2023505847 hasConcept C23849879 @default.
• W2023505847 hasConcept C2776217839 @default.
• W2023505847 hasConcept C2776253728 @default.
• W2023505847 hasConcept C2777730290 @default.
• W2023505847 hasConcept C2779219270 @default.
• W2023505847 hasConcept C55493867 @default.
• W2023505847 hasConcept C57074206 @default.
• W2023505847 hasConcept C62478195 @default.
• W2023505847 hasConcept C86803240 @default.
• W2023505847 hasConcept C95444343 @default.
• W2023505847 hasConceptScore W2023505847C181199279 @default.
• W2023505847 hasConceptScore W2023505847C23849879 @default.

• next