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• W2023506257 abstract "Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors.To determine if AD+P aggregates within families.Case-control study of AD+P frequency in 461 siblings of 371 probands diagnosed with AD. All siblings were ascertained as part of a genetic investigation and also were diagnosed with AD. Statistical analysis used Generalized Estimating Equations to adjust for clustering within families.AD+P in probands was associated with a significantly increased risk for AD+P in family members (OR, 2.41; 95% CI 1.46-4.0; p = 0.0006). The correlation among siblings for AD+P status was modest: 0.16.AD+P demonstrates familial aggregation. Further studies are required to investigate a possible genetic basis of AD+P." @default.
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• W2023506257 date "2002-03-26" @default.
• W2023506257 modified "2023-09-25" @default.
• W2023506257 title "Increased familial risk of the psychotic phenotype of Alzheimer disease" @default.
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• W2023506257 doi "https://doi.org/10.1212/wnl.58.6.907" @default.
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