Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023507149> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2023507149 endingPage "19" @default.
- W2023507149 startingPage "7" @default.
- W2023507149 abstract "The levels of steroids in prostatic tissues were determined by radioimmunoassay after solvent extraction of a single (300–600 mg wet tissue) sample and chromatography of extracts on hydroxyalkoxypropyl Sephadex microcolumns. In normal adult prostates ( n = 18) the concentrations of steroids (mean± s.e.m. ng/g wet tissue) were: testosterone, 0·25 ± 0·04; androstenedione, 0·13 ± 0·03; 5α-androstane-3, 17-dione (5α-androstanedione), 1·31 ± 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone, DHT), 1·22± 0·14; 5α-androstane-3α, 17β-diol (3α-androstanediol), 4·32 ± 0·49; androsterone, 4·15± 1·07; progesterone, 0·39 ± 0·07; 17α-hydroxyprogesterone, 0·42 ± 0·06. Concentrations of steroids in tissues from outer-gland regions were within the ranges found in the periurethral regions. In the prostates of newborn boys, the concentrations of all steroids were high, including progesterone and 17α-hydroxyprogesterone. Apart from 3α-androstanediol, the levels of which tend to increase after this age, the concentrations of all steroids were lower in the infant and pubertal prostates, but most were re-established to a variable extent in the adult tissues. This was particularly evident with respect to 5α-androstanedione and androsterone, and it is suggested that these two androgens may have a functional role in the mature prostate. The concentrations of testosterone, androstenedione, 5α-androstanedione, progesterone and 17α-hydroxyprogesterone in tissues taken from ten patients with benign prostatic hypertrophy (BPH) were similar to those in normal adult tissue. The concentration of DHT was markedly raised (5·33 ± 0·46 ng/g) and the levels of 3α-androstanediol and androsterone were reduced (1·40 ± 0·12 and 0·80 ± 0·12 ng/g respectively) in adenomatous compared with normal tissue. The concentrations of various androgens displayed remarkable inter-relationships which characterize normal and BPH tissues. The concentrations of testosterone, androstenedione, DHT and 3α-androstanediol were particularly high in the untreated prostatic carcinomatous tissue sample investigated, whereas the concentrations of 5α-androstanedione and androsterone were very low. After oestrogen treatment, testosterone and androstenedione virtually disappeared, while reduced but significant concentrations of their metabolites remained in similar proportions to those observed in the untreated carcinomatous tissue. Under the conditions of therapy, oestrogens are suggested to influence the uptake of androgens." @default.
- W2023507149 created "2016-06-24" @default.
- W2023507149 creator A5029961192 @default.
- W2023507149 date "1978-07-01" @default.
- W2023507149 modified "2023-09-27" @default.
- W2023507149 title "ENDOGENOUS STEROID LEVELS IN THE HUMAN PROSTATE FROM BIRTH TO OLD AGE: A COMPARISON OF NORMAL AND DISEASED TISSUES" @default.
- W2023507149 doi "https://doi.org/10.1677/joe.0.0780007" @default.
- W2023507149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/79632" @default.
- W2023507149 hasPublicationYear "1978" @default.
- W2023507149 type Work @default.
- W2023507149 sameAs 2023507149 @default.
- W2023507149 citedByCount "134" @default.
- W2023507149 countsByYear W20235071492012 @default.
- W2023507149 countsByYear W20235071492015 @default.
- W2023507149 countsByYear W20235071492017 @default.
- W2023507149 countsByYear W20235071492018 @default.
- W2023507149 countsByYear W20235071492022 @default.
- W2023507149 crossrefType "journal-article" @default.
- W2023507149 hasAuthorship W2023507149A5029961192 @default.
- W2023507149 hasConcept C121608353 @default.
- W2023507149 hasConcept C126322002 @default.
- W2023507149 hasConcept C134018914 @default.
- W2023507149 hasConcept C167414201 @default.
- W2023507149 hasConcept C176685330 @default.
- W2023507149 hasConcept C185592680 @default.
- W2023507149 hasConcept C2776235491 @default.
- W2023507149 hasConcept C2776683971 @default.
- W2023507149 hasConcept C2777911890 @default.
- W2023507149 hasConcept C2779279991 @default.
- W2023507149 hasConcept C2779746161 @default.
- W2023507149 hasConcept C2779881493 @default.
- W2023507149 hasConcept C2780902042 @default.
- W2023507149 hasConcept C71315377 @default.
- W2023507149 hasConcept C71924100 @default.
- W2023507149 hasConcept C86803240 @default.
- W2023507149 hasConceptScore W2023507149C121608353 @default.
- W2023507149 hasConceptScore W2023507149C126322002 @default.
- W2023507149 hasConceptScore W2023507149C134018914 @default.
- W2023507149 hasConceptScore W2023507149C167414201 @default.
- W2023507149 hasConceptScore W2023507149C176685330 @default.
- W2023507149 hasConceptScore W2023507149C185592680 @default.
- W2023507149 hasConceptScore W2023507149C2776235491 @default.
- W2023507149 hasConceptScore W2023507149C2776683971 @default.
- W2023507149 hasConceptScore W2023507149C2777911890 @default.
- W2023507149 hasConceptScore W2023507149C2779279991 @default.
- W2023507149 hasConceptScore W2023507149C2779746161 @default.
- W2023507149 hasConceptScore W2023507149C2779881493 @default.
- W2023507149 hasConceptScore W2023507149C2780902042 @default.
- W2023507149 hasConceptScore W2023507149C71315377 @default.
- W2023507149 hasConceptScore W2023507149C71924100 @default.
- W2023507149 hasConceptScore W2023507149C86803240 @default.
- W2023507149 hasIssue "1" @default.
- W2023507149 hasLocation W20235071491 @default.
- W2023507149 hasLocation W20235071492 @default.
- W2023507149 hasOpenAccess W2023507149 @default.
- W2023507149 hasPrimaryLocation W20235071491 @default.
- W2023507149 hasRelatedWork W1967975371 @default.
- W2023507149 hasRelatedWork W1971529801 @default.
- W2023507149 hasRelatedWork W1979102595 @default.
- W2023507149 hasRelatedWork W1981433740 @default.
- W2023507149 hasRelatedWork W2002995968 @default.
- W2023507149 hasRelatedWork W2011535479 @default.
- W2023507149 hasRelatedWork W2026882188 @default.
- W2023507149 hasRelatedWork W2038277505 @default.
- W2023507149 hasRelatedWork W2053511509 @default.
- W2023507149 hasRelatedWork W2159598174 @default.
- W2023507149 hasVolume "78" @default.
- W2023507149 isParatext "false" @default.
- W2023507149 isRetracted "false" @default.
- W2023507149 magId "2023507149" @default.
- W2023507149 workType "article" @default.