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• W2023507189 abstract "Embryonic stem-like (ES-like) cells have now been derived from the inner cell mass (ICM) of horse embryos at the blastocyst stage. Because they have been shown to express cell-surface antigens found in both human and mouse ES cells, the present study investigated gene expression patterns in day-7 horse blastocysts from which the horse ES-like cells had been derived originally. The genes studied included Oct-4, stage-specific embryonic antigen-1 (SSEA-1), SSEA-3, SSEA-4, tumor rejection antigen-1-60 (TRA-1-60), TRA-1-81, and alkaline phosphatase activity, and whereas all three of the SSEA antigens were expressed in both the ICM and the trophoblast on day 7, Oct-4, TRA-1-60, TRA-1-81, and alkaline phosphatase activity were localized mostly in the ICM. Upon in vitro differentiation of the horse ES-like cells, their expression of the stem cell markers was abolished. Therefore, the species-specific expression pattern of stem cell markers in horse ES-like cells reflects gene expression in the blastocysts from which they are derived." @default.
• W2023507189 created "2016-06-24" @default.
• W2023507189 creator A5000535977 @default.
• W2023507189 creator A5082947432 @default.
• W2023507189 date "2007-10-01" @default.
• W2023507189 modified "2023-09-23" @default.
• W2023507189 title "Expression of Cell-Surface Antigens and Embryonic Stem Cell Pluripotency Genes in Equine Blastocysts" @default.
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• W2023507189 doi "https://doi.org/10.1089/scd.2007.0032" @default.
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