Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023507191> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2023507191 endingPage "488" @default.
- W2023507191 startingPage "481" @default.
- W2023507191 abstract "Amphiregulin (AR) is a polypeptide growth regulator which has sequence homology to the epidermal growth factor-related family of ligands and contains putative nuclear targeting sequences. Human ovarian carcinoma cell lines and their normal counterparts, ovarian surface epithelial cells (OSEs), were assessed for their ability to respond to and express AR. Addition of exogenous AR (8-200 pM) inhibited the growth of 2 of 3 OSE specimens and 3 of the 6 carcinoma cell lines indicating that AR has the potential to inhibit the growth of normal cells, in addition to carcinoma cells. In contrast, concentrations of AR ranging from 1-5 nM stimulated the growth of all 3 of the OSEs and 4 of the 6 carcinoma cell lines. Immunocytochemical staining of the cells using antipeptide antibodies directed against residues 8-26 of AR indicated that all cells expressed AR and that the staining was localized to the nucleus. The nuclear staining of AR was concentrated in the nucleolus of the carcinoma cells, whereas the staining was diffuse in the nucleus of the OSEs. These results suggest that AR may play a growth regulatory role in the nucleus of cells and this role may be different in normal and malignant epithelial cells." @default.
- W2023507191 created "2016-06-24" @default.
- W2023507191 creator A5001484555 @default.
- W2023507191 creator A5025091669 @default.
- W2023507191 creator A5027758178 @default.
- W2023507191 creator A5034349158 @default.
- W2023507191 creator A5058592673 @default.
- W2023507191 creator A5075647429 @default.
- W2023507191 creator A5082161558 @default.
- W2023507191 date "1991-10-01" @default.
- W2023507191 modified "2023-10-13" @default.
- W2023507191 title "Response to and expression of amphiregulin by ovarian carcinoma and normal ovarian surface epithelial cells: Nuclear localization of endogenous amphiregulin" @default.
- W2023507191 cites W186804289 @default.
- W2023507191 cites W2031308797 @default.
- W2023507191 cites W2036033314 @default.
- W2023507191 cites W2038086562 @default.
- W2023507191 cites W2097988206 @default.
- W2023507191 cites W2101991542 @default.
- W2023507191 cites W2124806986 @default.
- W2023507191 cites W2134551213 @default.
- W2023507191 cites W2165534710 @default.
- W2023507191 cites W4252105406 @default.
- W2023507191 doi "https://doi.org/10.1016/s0006-291x(05)81090-3" @default.
- W2023507191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1953719" @default.
- W2023507191 hasPublicationYear "1991" @default.
- W2023507191 type Work @default.
- W2023507191 sameAs 2023507191 @default.
- W2023507191 citedByCount "96" @default.
- W2023507191 countsByYear W20235071912012 @default.
- W2023507191 countsByYear W20235071912013 @default.
- W2023507191 countsByYear W20235071912014 @default.
- W2023507191 countsByYear W20235071912016 @default.
- W2023507191 countsByYear W20235071912018 @default.
- W2023507191 countsByYear W20235071912019 @default.
- W2023507191 countsByYear W20235071912021 @default.
- W2023507191 countsByYear W20235071912023 @default.
- W2023507191 crossrefType "journal-article" @default.
- W2023507191 hasAuthorship W2023507191A5001484555 @default.
- W2023507191 hasAuthorship W2023507191A5025091669 @default.
- W2023507191 hasAuthorship W2023507191A5027758178 @default.
- W2023507191 hasAuthorship W2023507191A5034349158 @default.
- W2023507191 hasAuthorship W2023507191A5058592673 @default.
- W2023507191 hasAuthorship W2023507191A5075647429 @default.
- W2023507191 hasAuthorship W2023507191A5082161558 @default.
- W2023507191 hasConcept C121608353 @default.
- W2023507191 hasConcept C153911025 @default.
- W2023507191 hasConcept C185592680 @default.
- W2023507191 hasConcept C2776362946 @default.
- W2023507191 hasConcept C2777546739 @default.
- W2023507191 hasConcept C2780114586 @default.
- W2023507191 hasConcept C2780427987 @default.
- W2023507191 hasConcept C2780723820 @default.
- W2023507191 hasConcept C2780806702 @default.
- W2023507191 hasConcept C3019054536 @default.
- W2023507191 hasConcept C54355233 @default.
- W2023507191 hasConcept C55493867 @default.
- W2023507191 hasConcept C62112901 @default.
- W2023507191 hasConcept C74864618 @default.
- W2023507191 hasConcept C81885089 @default.
- W2023507191 hasConcept C86803240 @default.
- W2023507191 hasConcept C95444343 @default.
- W2023507191 hasConceptScore W2023507191C121608353 @default.
- W2023507191 hasConceptScore W2023507191C153911025 @default.
- W2023507191 hasConceptScore W2023507191C185592680 @default.
- W2023507191 hasConceptScore W2023507191C2776362946 @default.
- W2023507191 hasConceptScore W2023507191C2777546739 @default.
- W2023507191 hasConceptScore W2023507191C2780114586 @default.
- W2023507191 hasConceptScore W2023507191C2780427987 @default.
- W2023507191 hasConceptScore W2023507191C2780723820 @default.
- W2023507191 hasConceptScore W2023507191C2780806702 @default.
- W2023507191 hasConceptScore W2023507191C3019054536 @default.
- W2023507191 hasConceptScore W2023507191C54355233 @default.
- W2023507191 hasConceptScore W2023507191C55493867 @default.
- W2023507191 hasConceptScore W2023507191C62112901 @default.
- W2023507191 hasConceptScore W2023507191C74864618 @default.
- W2023507191 hasConceptScore W2023507191C81885089 @default.
- W2023507191 hasConceptScore W2023507191C86803240 @default.
- W2023507191 hasConceptScore W2023507191C95444343 @default.
- W2023507191 hasIssue "2" @default.
- W2023507191 hasLocation W20235071911 @default.
- W2023507191 hasLocation W20235071912 @default.
- W2023507191 hasOpenAccess W2023507191 @default.
- W2023507191 hasPrimaryLocation W20235071911 @default.
- W2023507191 hasRelatedWork W1876089425 @default.
- W2023507191 hasRelatedWork W1971433918 @default.
- W2023507191 hasRelatedWork W1990805186 @default.
- W2023507191 hasRelatedWork W2003396164 @default.
- W2023507191 hasRelatedWork W2010550967 @default.
- W2023507191 hasRelatedWork W2043317027 @default.
- W2023507191 hasRelatedWork W2062776037 @default.
- W2023507191 hasRelatedWork W2145577915 @default.
- W2023507191 hasRelatedWork W288737898 @default.
- W2023507191 hasRelatedWork W4246600873 @default.
- W2023507191 hasVolume "180" @default.
- W2023507191 isParatext "false" @default.
- W2023507191 isRetracted "false" @default.
- W2023507191 magId "2023507191" @default.
- W2023507191 workType "article" @default.