Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023507382> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2023507382 endingPage "100" @default.
- W2023507382 startingPage "93" @default.
- W2023507382 abstract "Microvessels in the cheek pouch of the hamster were investigated to determine their structural, reactivity, and permeability characteristics after the induction of diabetes. To induce diabetes, hamsters were injected with streptozotocin (50 mg/kg body wt./day, i.p., for 3 days). Vehicle-injected, age-matched hamsters were the controls. Diabetic hamsters were characterized by elevated serum glucose (greater than 300 mg/dl) and triglycerides and decreased serum insulin (50%). Microvascular studies were completed on cheek pouch microvessels suffused with Ringer's solution (37 degrees C, pH 7.4) bubbled with 95% N2-5% CO2. Vascular dimensions and reactivity of selected arterioles and venules to microapplications of norepinephrine were determined with a video micrometer using intravital microscopy. Restrictiveness of the microvascular membranes to fluorescein-labeled dextran fractions (mol wt: 150,000; 40,000; 20,000 daltons) was measured by determining the number of leaky sites. Stimulation of membrane permeability by histamine was investigated. There were no major alterations in arteriolar lumen and wall diameters, whereas venular lumen diameters were increased in hamsters diabetic for two months. Likewise, arteriolar responses to norepinephrine were not altered by diabetes; however, venular responses were decreased at two months. The restrictiveness of the vascular membrane to various dextran fractions was dramatically decreased in the diabetic animals at two months. Histamine did not alter microvascular leakage in the diabetic as it did in the normal hamsters. These studies indicate that microvascular alterations, venular dilation, and increased permeability to large molecules occur in the diabetic hamster within two months after the induction of diabetes." @default.
- W2023507382 created "2016-06-24" @default.
- W2023507382 creator A5002882206 @default.
- W2023507382 creator A5042770255 @default.
- W2023507382 creator A5044908351 @default.
- W2023507382 creator A5077649843 @default.
- W2023507382 date "1981-02-01" @default.
- W2023507382 modified "2023-09-27" @default.
- W2023507382 title "Microvascular Alterations Develop in Syrian Hamsters After the Induction of Diabetes Mellitus by Streptozotocin" @default.
- W2023507382 doi "https://doi.org/10.2337/diab.30.2.93" @default.
- W2023507382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6162695" @default.
- W2023507382 hasPublicationYear "1981" @default.
- W2023507382 type Work @default.
- W2023507382 sameAs 2023507382 @default.
- W2023507382 citedByCount "28" @default.
- W2023507382 countsByYear W20235073822015 @default.
- W2023507382 countsByYear W20235073822019 @default.
- W2023507382 countsByYear W20235073822021 @default.
- W2023507382 crossrefType "journal-article" @default.
- W2023507382 hasAuthorship W2023507382A5002882206 @default.
- W2023507382 hasAuthorship W2023507382A5042770255 @default.
- W2023507382 hasAuthorship W2023507382A5044908351 @default.
- W2023507382 hasAuthorship W2023507382A5077649843 @default.
- W2023507382 hasConcept C1122143 @default.
- W2023507382 hasConcept C113045295 @default.
- W2023507382 hasConcept C126322002 @default.
- W2023507382 hasConcept C12722491 @default.
- W2023507382 hasConcept C134018914 @default.
- W2023507382 hasConcept C146957229 @default.
- W2023507382 hasConcept C185592680 @default.
- W2023507382 hasConcept C2776436680 @default.
- W2023507382 hasConcept C2778575167 @default.
- W2023507382 hasConcept C2779280383 @default.
- W2023507382 hasConcept C2779306644 @default.
- W2023507382 hasConcept C2780394083 @default.
- W2023507382 hasConcept C2859252 @default.
- W2023507382 hasConcept C34439696 @default.
- W2023507382 hasConcept C555293320 @default.
- W2023507382 hasConcept C71924100 @default.
- W2023507382 hasConceptScore W2023507382C1122143 @default.
- W2023507382 hasConceptScore W2023507382C113045295 @default.
- W2023507382 hasConceptScore W2023507382C126322002 @default.
- W2023507382 hasConceptScore W2023507382C12722491 @default.
- W2023507382 hasConceptScore W2023507382C134018914 @default.
- W2023507382 hasConceptScore W2023507382C146957229 @default.
- W2023507382 hasConceptScore W2023507382C185592680 @default.
- W2023507382 hasConceptScore W2023507382C2776436680 @default.
- W2023507382 hasConceptScore W2023507382C2778575167 @default.
- W2023507382 hasConceptScore W2023507382C2779280383 @default.
- W2023507382 hasConceptScore W2023507382C2779306644 @default.
- W2023507382 hasConceptScore W2023507382C2780394083 @default.
- W2023507382 hasConceptScore W2023507382C2859252 @default.
- W2023507382 hasConceptScore W2023507382C34439696 @default.
- W2023507382 hasConceptScore W2023507382C555293320 @default.
- W2023507382 hasConceptScore W2023507382C71924100 @default.
- W2023507382 hasIssue "2" @default.
- W2023507382 hasLocation W20235073821 @default.
- W2023507382 hasLocation W20235073822 @default.
- W2023507382 hasOpenAccess W2023507382 @default.
- W2023507382 hasPrimaryLocation W20235073821 @default.
- W2023507382 hasRelatedWork W1977225442 @default.
- W2023507382 hasRelatedWork W2003485540 @default.
- W2023507382 hasRelatedWork W2007232677 @default.
- W2023507382 hasRelatedWork W2023507382 @default.
- W2023507382 hasRelatedWork W2044988659 @default.
- W2023507382 hasRelatedWork W2112457773 @default.
- W2023507382 hasRelatedWork W2131147582 @default.
- W2023507382 hasRelatedWork W2434287781 @default.
- W2023507382 hasRelatedWork W2475120501 @default.
- W2023507382 hasRelatedWork W57335222 @default.
- W2023507382 hasVolume "30" @default.
- W2023507382 isParatext "false" @default.
- W2023507382 isRetracted "false" @default.
- W2023507382 magId "2023507382" @default.
- W2023507382 workType "article" @default.