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• W2023507770 abstract "Chondromodulin-I expression in the growth plate of young uremic rats.BackgroundGrowth retardation of chronic renal failure is associated with alterations in the growth plate suggestive of a disturbed chondrocyte maturation process and abnormal vascular invasion at the chondro-osseous interphase. Chondromodulin I (ChM-I) is a potent cartilage-specific angiostatic factor. Its pattern of expression in the uremic rat growth plate is unknown. Persistence of ChM-I synthesis and/or imbalance between ChM-I and vascular endothelial growth factor (VEGF) expressions might play a role in the alterations of uremic growth plate.MethodsGrowth cartilage ChM-I expression was investigated by immunohistochemistry, in situ hybridization, and reverse transcription-polymerase chain reaction (RT-PCR) in growth-retarded young uremic rats (UREM), control rats, fed ad libitum (SAL) or pair-fed with the UREM group (SPF), and uremic rats treated with growth hormone (UREM-GH). VEGF expression was analyzed by immunohistochemistry.ResultsChM-I and ChM-I mRNA were confined to the proliferative and early hypertrophic zones of growth cartilage. A similar number of chondrocytes per column was positive for ChM-I in the 4 groups. In accordance with the elongation of the hypertrophic stratum in uremia, the distance (X±SEM, μm) between the extracellular ChM-I signal and the metaphyseal end of growth cartilage was higher (P < 0.003) in UREM (236 ± 40) and UREM-GH (297 ± 17) than in SAL (92 ± 7) and SPF (113 ± 6). No differences in ChM-I expression were appreciated by RT-PCR. Similar VEGF positivity was observed in the hypertrophic chondrocytes of all groups.ConclusionIn experimental uremia, expansion of growth cartilage does not result from increased or persistent expression of ChM-I or from reduced VEGF expression at the cartilage-metaphyseal bone interphase. GH treatment does not modify ChM-I and VEGF expressions. Chondromodulin-I expression in the growth plate of young uremic rats. Growth retardation of chronic renal failure is associated with alterations in the growth plate suggestive of a disturbed chondrocyte maturation process and abnormal vascular invasion at the chondro-osseous interphase. Chondromodulin I (ChM-I) is a potent cartilage-specific angiostatic factor. Its pattern of expression in the uremic rat growth plate is unknown. Persistence of ChM-I synthesis and/or imbalance between ChM-I and vascular endothelial growth factor (VEGF) expressions might play a role in the alterations of uremic growth plate. Growth cartilage ChM-I expression was investigated by immunohistochemistry, in situ hybridization, and reverse transcription-polymerase chain reaction (RT-PCR) in growth-retarded young uremic rats (UREM), control rats, fed ad libitum (SAL) or pair-fed with the UREM group (SPF), and uremic rats treated with growth hormone (UREM-GH). VEGF expression was analyzed by immunohistochemistry. ChM-I and ChM-I mRNA were confined to the proliferative and early hypertrophic zones of growth cartilage. A similar number of chondrocytes per column was positive for ChM-I in the 4 groups. In accordance with the elongation of the hypertrophic stratum in uremia, the distance (X±SEM, μm) between the extracellular ChM-I signal and the metaphyseal end of growth cartilage was higher (P < 0.003) in UREM (236 ± 40) and UREM-GH (297 ± 17) than in SAL (92 ± 7) and SPF (113 ± 6). No differences in ChM-I expression were appreciated by RT-PCR. Similar VEGF positivity was observed in the hypertrophic chondrocytes of all groups. In experimental uremia, expansion of growth cartilage does not result from increased or persistent expression of ChM-I or from reduced VEGF expression at the cartilage-metaphyseal bone interphase. GH treatment does not modify ChM-I and VEGF expressions." @default.
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• W2023507770 date "2004-07-01" @default.
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• W2023507770 title "Chondromodulin-I expression in the growth plate of young uremic rats" @default.
• W2023507770 cites W126383820 @default.
• W2023507770 cites W1583699618 @default.
• W2023507770 cites W1963631377 @default.
• W2023507770 cites W1964371441 @default.
• W2023507770 cites W1967870391 @default.
• W2023507770 cites W1968800022 @default.
• W2023507770 cites W1970294868 @default.
• W2023507770 cites W1977210005 @default.
• W2023507770 cites W1982639119 @default.
• W2023507770 cites W1982655691 @default.
• W2023507770 cites W1983221409 @default.
• W2023507770 cites W1988178572 @default.
• W2023507770 cites W1988791271 @default.
• W2023507770 cites W1992006238 @default.
• W2023507770 cites W1995016250 @default.
• W2023507770 cites W1998132448 @default.
• W2023507770 cites W1998817545 @default.
• W2023507770 cites W2001048365 @default.
• W2023507770 cites W2004227066 @default.
• W2023507770 cites W2009811838 @default.
• W2023507770 cites W2015834321 @default.
• W2023507770 cites W2018625144 @default.
• W2023507770 cites W2023049897 @default.
• W2023507770 cites W2030487871 @default.
• W2023507770 cites W2041808802 @default.
• W2023507770 cites W2048662407 @default.
• W2023507770 cites W2049666627 @default.
• W2023507770 cites W2057202661 @default.
• W2023507770 cites W2065722470 @default.
• W2023507770 cites W2075043838 @default.
• W2023507770 cites W2078888308 @default.
• W2023507770 cites W2084037051 @default.
• W2023507770 cites W2085604023 @default.
• W2023507770 cites W2087556981 @default.
• W2023507770 cites W2091838563 @default.
• W2023507770 cites W2093325243 @default.
• W2023507770 cites W2093620105 @default.
• W2023507770 cites W2099799291 @default.
• W2023507770 cites W2114842734 @default.
• W2023507770 cites W2125980420 @default.
• W2023507770 cites W2133535546 @default.
• W2023507770 cites W2134812217 @default.
• W2023507770 cites W2137773273 @default.
• W2023507770 cites W2145308218 @default.
• W2023507770 cites W2149569285 @default.
• W2023507770 cites W2167225984 @default.
• W2023507770 cites W2181435250 @default.
• W2023507770 cites W2333975405 @default.
• W2023507770 cites W2396212953 @default.
• W2023507770 cites W2423426799 @default.
• W2023507770 cites W2464129225 @default.
• W2023507770 doi "https://doi.org/10.1111/j.1523-1755.2004.00708.x" @default.
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