FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023508382> ?p ?o ?g. }

• W2023508382 endingPage "131" @default.
• W2023508382 startingPage "126" @default.
• W2023508382 abstract "Long-term administration of clarithromycin has been reported to be effective in the treatment of chronic sinusitis. To investigate the mechanism underlying the anti-inflammatory activity of clarithromycin, the authors evaluated the effect of clarithromycin on the gene expression of proinflammatory cytokine and the DNA-binding activity of nuclear factor (NF)-kappa B in cultured human nasal epithelial cells and fibroblasts. Cells were incubated with endotoxin purified from nontypable Haemophilus influenzae or interleukin (IL)-1 beta in the presence of clarithromycin.Northern blot analysis revealed that clarithromycin suppressed IL-1 beta gene expression in human nasal epithelial cells stimulated by H. influenzae endotoxin (HIE). Intercellular adhesion molecule-1 gene expression in nasal fibroblasts stimulated by IL-1 beta was also suppressed by clarithromycin. Furthermore, electrophoretic mobility shift assay demonstrated that clarithromycin reduced DNA-binding activity of NF-kappa B in both human nasal epithelial cells and fibroblasts stimulated by HIE or IL-1 beta, respectively.The present results suggest that clarithromycin may reduce gene expression of proinflammatory cytokines and adhesion molecules from nasal mucosa at the transcriptional factor level and exert an anti-inflammatory effect on nasal mucosa in chronic sinusitis." @default.
• W2023508382 created "2016-06-24" @default.
• W2023508382 creator A5001411224 @default.
• W2023508382 creator A5021075864 @default.
• W2023508382 creator A5031044218 @default.
• W2023508382 creator A5071243832 @default.
• W2023508382 creator A5088219910 @default.
• W2023508382 creator A5089832553 @default.
• W2023508382 date "2000-01-01" @default.
• W2023508382 modified "2023-10-16" @default.
• W2023508382 title "Effects of Clarithromycin on Cultured Human Nasal Epithelial Cells and Fibroblasts" @default.
• W2023508382 cites W1871908972 @default.
• W2023508382 cites W1968740719 @default.
• W2023508382 cites W1977984401 @default.
• W2023508382 cites W1978418704 @default.
• W2023508382 cites W1987827515 @default.
• W2023508382 cites W1999126878 @default.
• W2023508382 cites W2007787190 @default.
• W2023508382 cites W2010237936 @default.
• W2023508382 cites W2010960519 @default.
• W2023508382 cites W2016730049 @default.
• W2023508382 cites W2018411138 @default.
• W2023508382 cites W2043200166 @default.
• W2023508382 cites W2057701451 @default.
• W2023508382 cites W2075256290 @default.
• W2023508382 cites W2078017838 @default.
• W2023508382 cites W2078109078 @default.
• W2023508382 cites W2102288149 @default.
• W2023508382 cites W2106339254 @default.
• W2023508382 cites W2113930416 @default.
• W2023508382 cites W2124849447 @default.
• W2023508382 cites W2128301658 @default.
• W2023508382 cites W2147524358 @default.
• W2023508382 cites W2148105091 @default.
• W2023508382 cites W2151892297 @default.
• W2023508382 cites W2158028015 @default.
• W2023508382 cites W2164800412 @default.
• W2023508382 cites W2168268806 @default.
• W2023508382 cites W2314425663 @default.
• W2023508382 cites W2323319707 @default.
• W2023508382 cites W2331176038 @default.
• W2023508382 cites W2437060102 @default.
• W2023508382 cites W2474734983 @default.
• W2023508382 cites W4294216491 @default.
• W2023508382 doi "https://doi.org/10.1097/00005537-200001000-00023" @default.
• W2023508382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10646728" @default.
• W2023508382 hasPublicationYear "2000" @default.
• W2023508382 type Work @default.
• W2023508382 sameAs 2023508382 @default.
• W2023508382 citedByCount "75" @default.
• W2023508382 countsByYear W20235083822012 @default.
• W2023508382 countsByYear W20235083822015 @default.
• W2023508382 countsByYear W20235083822016 @default.
• W2023508382 countsByYear W20235083822017 @default.
• W2023508382 countsByYear W20235083822018 @default.
• W2023508382 countsByYear W20235083822020 @default.
• W2023508382 countsByYear W20235083822021 @default.
• W2023508382 countsByYear W20235083822023 @default.
• W2023508382 crossrefType "journal-article" @default.
• W2023508382 hasAuthorship W2023508382A5001411224 @default.
• W2023508382 hasAuthorship W2023508382A5021075864 @default.
• W2023508382 hasAuthorship W2023508382A5031044218 @default.
• W2023508382 hasAuthorship W2023508382A5071243832 @default.
• W2023508382 hasAuthorship W2023508382A5088219910 @default.
• W2023508382 hasAuthorship W2023508382A5089832553 @default.
• W2023508382 hasBestOaLocation W20235083821 @default.
• W2023508382 hasConcept C104317684 @default.
• W2023508382 hasConcept C13373296 @default.
• W2023508382 hasConcept C150194340 @default.
• W2023508382 hasConcept C153911025 @default.
• W2023508382 hasConcept C164027704 @default.
• W2023508382 hasConcept C177707886 @default.
• W2023508382 hasConcept C203014093 @default.
• W2023508382 hasConcept C2776415932 @default.
• W2023508382 hasConcept C2776914184 @default.
• W2023508382 hasConcept C2776962512 @default.
• W2023508382 hasConcept C2778690821 @default.
• W2023508382 hasConcept C501593827 @default.
• W2023508382 hasConcept C55493867 @default.
• W2023508382 hasConcept C59377437 @default.
• W2023508382 hasConcept C68324877 @default.
• W2023508382 hasConcept C71924100 @default.
• W2023508382 hasConcept C86803240 @default.
• W2023508382 hasConcept C89423630 @default.
• W2023508382 hasConceptScore W2023508382C104317684 @default.
• W2023508382 hasConceptScore W2023508382C13373296 @default.
• W2023508382 hasConceptScore W2023508382C150194340 @default.
• W2023508382 hasConceptScore W2023508382C153911025 @default.
• W2023508382 hasConceptScore W2023508382C164027704 @default.
• W2023508382 hasConceptScore W2023508382C177707886 @default.
• W2023508382 hasConceptScore W2023508382C203014093 @default.
• W2023508382 hasConceptScore W2023508382C2776415932 @default.
• W2023508382 hasConceptScore W2023508382C2776914184 @default.
• W2023508382 hasConceptScore W2023508382C2776962512 @default.
• W2023508382 hasConceptScore W2023508382C2778690821 @default.
• W2023508382 hasConceptScore W2023508382C501593827 @default.
• W2023508382 hasConceptScore W2023508382C55493867 @default.
• W2023508382 hasConceptScore W2023508382C59377437 @default.

• next