FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023508534> ?p ?o ?g. }

• W2023508534 endingPage "59" @default.
• W2023508534 startingPage "47" @default.
• W2023508534 abstract "The limited efficiency of medical countermeasures against poisoning by nerve agent justifies efforts to find new prophylactic means and new antidotes. The concept of bioscavengers has emerged as an alternative approach to pharmacological pre- and post-exposure treatments. Catalytic scavengers are enzymes displaying a turnover with OPs as substrates, allowing rapid and efficient protection using administration of small doses. Several reasons have endorsed human paraoxonase (PON1) to be a pertinent candidate as catalytic bioscavenger. The physiological function of PON1 has not yet been unambiguously identified. Considered as a promiscuous enzyme, PON1 appears to be primarily a lactonase and also displays an anti-atherogenic activity closely linked to its localization on HDL particles. A HDL-associated phosphate transporter termed human phosphate binding protein (HPBP) was found to be a partner of natural human PON. In the absence of its natural environment (or mimicry by detergents), human PON1 is unstable and tends to aggregate. Converging data indicate that both the activity and the stability of PON1 are dramatically dependent on the HDL component molecular environment, including HPBP. Therefore, biochemical and physiological characterization of PON1–HPBP complexes, the environment allowing retaining functional enzyme state(s), and the thermal and storage stability of PON1 are mandatory. Synergistic efforts on characterization of recombinant hybrid PON1 expressed in E. coli and natural human PON1 provide information for the future rational design of stable mutants of PON1-based catalytic scavengers to be used as safe and effective countermeasures to OP intoxication." @default.
• W2023508534 created "2016-06-24" @default.
• W2023508534 creator A5015709474 @default.
• W2023508534 creator A5089589427 @default.
• W2023508534 creator A5089636420 @default.
• W2023508534 date "2007-04-01" @default.
• W2023508534 modified "2023-10-17" @default.
• W2023508534 title "Human paraoxonase: A promising approach for pre-treatment and therapy of organophosphorus poisoning" @default.
• W2023508534 cites W1648076111 @default.
• W2023508534 cites W1671050155 @default.
• W2023508534 cites W1966350492 @default.
• W2023508534 cites W1966493282 @default.
• W2023508534 cites W1971295796 @default.
• W2023508534 cites W1979547691 @default.
• W2023508534 cites W1980244533 @default.
• W2023508534 cites W1981302306 @default.
• W2023508534 cites W1983356705 @default.
• W2023508534 cites W1983931091 @default.
• W2023508534 cites W1986064397 @default.
• W2023508534 cites W1992165367 @default.
• W2023508534 cites W1996111288 @default.
• W2023508534 cites W2001265194 @default.
• W2023508534 cites W2003745868 @default.
• W2023508534 cites W2004893754 @default.
• W2023508534 cites W2004977638 @default.
• W2023508534 cites W2008600234 @default.
• W2023508534 cites W2011091423 @default.
• W2023508534 cites W2021395497 @default.
• W2023508534 cites W2022865333 @default.
• W2023508534 cites W2023602117 @default.
• W2023508534 cites W2026999474 @default.
• W2023508534 cites W2028893303 @default.
• W2023508534 cites W2030964561 @default.
• W2023508534 cites W2036010236 @default.
• W2023508534 cites W2038343400 @default.
• W2023508534 cites W2043386525 @default.
• W2023508534 cites W2046983748 @default.
• W2023508534 cites W2049613518 @default.
• W2023508534 cites W2053943424 @default.
• W2023508534 cites W2055424838 @default.
• W2023508534 cites W2060290647 @default.
• W2023508534 cites W2063669058 @default.
• W2023508534 cites W2065959195 @default.
• W2023508534 cites W2066280715 @default.
• W2023508534 cites W2066427675 @default.
• W2023508534 cites W2070586183 @default.
• W2023508534 cites W2077336844 @default.
• W2023508534 cites W2080249432 @default.
• W2023508534 cites W2081927835 @default.
• W2023508534 cites W2083626706 @default.
• W2023508534 cites W2084000678 @default.
• W2023508534 cites W2084075677 @default.
• W2023508534 cites W2085382883 @default.
• W2023508534 cites W2089435380 @default.
• W2023508534 cites W2090010489 @default.
• W2023508534 cites W2091022167 @default.
• W2023508534 cites W2094245618 @default.
• W2023508534 cites W2095857210 @default.
• W2023508534 cites W2099953575 @default.
• W2023508534 cites W2111891584 @default.
• W2023508534 cites W2115139514 @default.
• W2023508534 cites W2123094796 @default.
• W2023508534 cites W2138009331 @default.
• W2023508534 cites W2138875437 @default.
• W2023508534 cites W2144756483 @default.
• W2023508534 cites W2146411149 @default.
• W2023508534 cites W2150899510 @default.
• W2023508534 cites W2156492800 @default.
• W2023508534 cites W2157737368 @default.
• W2023508534 cites W2158303274 @default.
• W2023508534 cites W2158515926 @default.
• W2023508534 cites W2161414810 @default.
• W2023508534 cites W2161964918 @default.
• W2023508534 cites W2164259487 @default.
• W2023508534 cites W2188752118 @default.
• W2023508534 cites W2509336335 @default.
• W2023508534 doi "https://doi.org/10.1016/j.tox.2006.08.037" @default.
• W2023508534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17007987" @default.
• W2023508534 hasPublicationYear "2007" @default.
• W2023508534 type Work @default.
• W2023508534 sameAs 2023508534 @default.
• W2023508534 citedByCount "143" @default.
• W2023508534 countsByYear W20235085342012 @default.
• W2023508534 countsByYear W20235085342013 @default.
• W2023508534 countsByYear W20235085342014 @default.
• W2023508534 countsByYear W20235085342015 @default.
• W2023508534 countsByYear W20235085342016 @default.
• W2023508534 countsByYear W20235085342017 @default.
• W2023508534 countsByYear W20235085342018 @default.
• W2023508534 countsByYear W20235085342019 @default.
• W2023508534 countsByYear W20235085342020 @default.
• W2023508534 countsByYear W20235085342021 @default.
• W2023508534 countsByYear W20235085342022 @default.
• W2023508534 countsByYear W20235085342023 @default.
• W2023508534 crossrefType "journal-article" @default.
• W2023508534 hasAuthorship W2023508534A5015709474 @default.
• W2023508534 hasAuthorship W2023508534A5089589427 @default.
• W2023508534 hasAuthorship W2023508534A5089636420 @default.

• next