FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023509812> ?p ?o ?g. }

• W2023509812 endingPage "285" @default.
• W2023509812 startingPage "279" @default.
• W2023509812 abstract "Summary. The aims of the study were to investigate the efficacy of rescue therapy with lamivudine (LAM) and adefovir (ADV) combination for 6 months followed by ADV monotherapy in lamivudine‐resistant chronic hepatitis B (LAM‐R CHB) patients, and to analyze the frequency of ADV resistance mutant development in such patients. A total of 170 consecutive LAM‐R CHB patients (male/female: 130/40, mean age: 42.9 ± 13.4 years) with viral breakthrough under LAM therapy were analyzed. A total of 68 had HBeAg‐positive. Patients received rescue therapy with LAM [100 mg (qd)]+ADV [10 mg (qd)] for 6 months after which LAM was discontinued. HBV‐DNA was assessed with the HBV‐DNA 3.0 bDNA assay. ADV‐resistant mutations were identified by sequencing the reverse transcriptase region. The median duration of rescue therapy was 24 months. Cumulative probability of becoming HBV‐DNA undetectable was 33.8%, 59.6% and 68.2% after 24, 48 and 96 weeks of treatment, respectively. These figures were 43.2%, 58.0% and 73.1% for ALT normalization. Among 68 HBeAg‐positive CHB patients, 10 patients had an e‐antigen seroconversion. Low baseline HBV‐DNA level (<10 7 copies/mL) was a significant predictor of response to ADV treatment ( P < 0.01). Cumulative probability of ADV resistance was 1.2%, 15.1% and 37.3% at 12, 24 and 36 months of therapy, respectively. By multivariate analysis, baseline high viral load and primary nonresponse to treatment at week 24 predicted ADV resistance. The data indicate that a time limited add‐on strategy does not provide benefit over the switch strategy with respect emergence of ADV resistant mutants in LAM‐R CHB patients." @default.
• W2023509812 created "2016-06-24" @default.
• W2023509812 creator A5000468433 @default.
• W2023509812 creator A5005523046 @default.
• W2023509812 creator A5013841764 @default.
• W2023509812 creator A5014406633 @default.
• W2023509812 creator A5024219904 @default.
• W2023509812 creator A5030413648 @default.
• W2023509812 creator A5035630604 @default.
• W2023509812 creator A5036482660 @default.
• W2023509812 creator A5040137032 @default.
• W2023509812 creator A5054620156 @default.
• W2023509812 creator A5070173494 @default.
• W2023509812 creator A5074875731 @default.
• W2023509812 creator A5083768592 @default.
• W2023509812 creator A5088602858 @default.
• W2023509812 date "2009-03-01" @default.
• W2023509812 modified "2023-10-14" @default.
• W2023509812 title "A short course of add-on adefovir dipivoxil treatment in lamivudine-resistant chronic hepatitis B patients" @default.
• W2023509812 cites W133318803 @default.
• W2023509812 cites W1982960788 @default.
• W2023509812 cites W1985860298 @default.
• W2023509812 cites W2004054613 @default.
• W2023509812 cites W2009944703 @default.
• W2023509812 cites W2011269097 @default.
• W2023509812 cites W2016449892 @default.
• W2023509812 cites W2020985855 @default.
• W2023509812 cites W2041268417 @default.
• W2023509812 cites W2049902316 @default.
• W2023509812 cites W2065099361 @default.
• W2023509812 cites W2069992406 @default.
• W2023509812 cites W2080268748 @default.
• W2023509812 cites W2088280741 @default.
• W2023509812 cites W2090126805 @default.
• W2023509812 cites W2108147025 @default.
• W2023509812 cites W2115956200 @default.
• W2023509812 cites W2116148860 @default.
• W2023509812 cites W2120667564 @default.
• W2023509812 cites W2123543307 @default.
• W2023509812 cites W2135530830 @default.
• W2023509812 cites W2137544368 @default.
• W2023509812 cites W2142557452 @default.
• W2023509812 cites W2143584498 @default.
• W2023509812 cites W2144084705 @default.
• W2023509812 cites W2149498593 @default.
• W2023509812 cites W2156015715 @default.
• W2023509812 cites W2156552801 @default.
• W2023509812 cites W2163480483 @default.
• W2023509812 cites W2393327590 @default.
• W2023509812 cites W2426100515 @default.
• W2023509812 cites W4247967755 @default.
• W2023509812 doi "https://doi.org/10.1111/j.1365-2893.2009.01074.x" @default.
• W2023509812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19222742" @default.
• W2023509812 hasPublicationYear "2009" @default.
• W2023509812 type Work @default.
• W2023509812 sameAs 2023509812 @default.
• W2023509812 citedByCount "19" @default.
• W2023509812 countsByYear W20235098122012 @default.
• W2023509812 countsByYear W20235098122013 @default.
• W2023509812 countsByYear W20235098122014 @default.
• W2023509812 countsByYear W20235098122015 @default.
• W2023509812 countsByYear W20235098122018 @default.
• W2023509812 crossrefType "journal-article" @default.
• W2023509812 hasAuthorship W2023509812A5000468433 @default.
• W2023509812 hasAuthorship W2023509812A5005523046 @default.
• W2023509812 hasAuthorship W2023509812A5013841764 @default.
• W2023509812 hasAuthorship W2023509812A5014406633 @default.
• W2023509812 hasAuthorship W2023509812A5024219904 @default.
• W2023509812 hasAuthorship W2023509812A5030413648 @default.
• W2023509812 hasAuthorship W2023509812A5035630604 @default.
• W2023509812 hasAuthorship W2023509812A5036482660 @default.
• W2023509812 hasAuthorship W2023509812A5040137032 @default.
• W2023509812 hasAuthorship W2023509812A5054620156 @default.
• W2023509812 hasAuthorship W2023509812A5070173494 @default.
• W2023509812 hasAuthorship W2023509812A5074875731 @default.
• W2023509812 hasAuthorship W2023509812A5083768592 @default.
• W2023509812 hasAuthorship W2023509812A5088602858 @default.
• W2023509812 hasConcept C114851261 @default.
• W2023509812 hasConcept C126322002 @default.
• W2023509812 hasConcept C142462285 @default.
• W2023509812 hasConcept C151678543 @default.
• W2023509812 hasConcept C159047783 @default.
• W2023509812 hasConcept C2522874641 @default.
• W2023509812 hasConcept C2775940106 @default.
• W2023509812 hasConcept C2776175608 @default.
• W2023509812 hasConcept C2776999253 @default.
• W2023509812 hasConcept C2777382497 @default.
• W2023509812 hasConcept C2777410769 @default.
• W2023509812 hasConcept C2777451964 @default.
• W2023509812 hasConcept C2777869810 @default.
• W2023509812 hasConcept C2779517838 @default.
• W2023509812 hasConcept C2780593183 @default.
• W2023509812 hasConcept C3020491458 @default.
• W2023509812 hasConcept C71924100 @default.
• W2023509812 hasConcept C72563966 @default.
• W2023509812 hasConcept C86803240 @default.
• W2023509812 hasConcept C88879693 @default.
• W2023509812 hasConcept C89423630 @default.

• next