FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023526034> ?p ?o ?g. }

• W2023526034 endingPage "422" @default.
• W2023526034 startingPage "413" @default.
• W2023526034 abstract "125I-iododerivatives of the insect toxin (AaH IT1) from Androctonus australis Hector and of one toxin (Ts VII) from Tityus serrulatus were purified by high performance liquid chromatography (HPLC) and used in binding experiments on a nerve cord synaptosomal fraction of cockroach (P. americana). [125I]AaH IT1-b binds specifically and reversibly to a single class of non-interacting binding sites of high affinity (Kd∗ = 0.14 ± 0.06 nM, n = 5) and low capacity (1.7 ± 0.6 pmol/mg protein). The association (k1) and dissociation (k−1) constants are 3 × 106 M−1 s−1 (n = 2) and 7 × 10−4 s−1 (n = 2), respectively, and are in good agreement with the equilibrium constant. The interaction of [125I]Ts VII-d was irreversible and the association kinetics constant (k) was 2–5 × 107 M−1 s−1 (n = 4). As already shown Ts VII and AaH IT1 compete for the same binding site. The binding site capacity of [125I]Ts VII-d (1.6 ± 0.12 pmol/mg of protein, n = 2) was similar to that obtained with [125I]AaH IT1-b in the present experiments and with [125I]AaH IT1 on an insect synaptosomal fraction of central nervous system, and to that of a similar toxin (toxin γ) on rat brain synaptosomes. The injection of Ts VII in the sixth abdominal ganglion of the cockroach induces a progressive decrease in excitatory postsynaptic potentials and action potential." @default.
• W2023526034 created "2016-06-24" @default.
• W2023526034 creator A5019399185 @default.
• W2023526034 creator A5049926824 @default.
• W2023526034 creator A5073392669 @default.
• W2023526034 creator A5077576317 @default.
• W2023526034 creator A5091234260 @default.
• W2023526034 date "1989-01-01" @default.
• W2023526034 modified "2023-10-07" @default.
• W2023526034 title "On the binding of two scorpion toxins to the central nervous system of the cockroach Periplaneta americana" @default.
• W2023526034 cites W1542790713 @default.
• W2023526034 cites W1573664132 @default.
• W2023526034 cites W1963821573 @default.
• W2023526034 cites W1981061160 @default.
• W2023526034 cites W1981073143 @default.
• W2023526034 cites W1986233298 @default.
• W2023526034 cites W1997990338 @default.
• W2023526034 cites W2000817861 @default.
• W2023526034 cites W2006504693 @default.
• W2023526034 cites W2011224602 @default.
• W2023526034 cites W2014544763 @default.
• W2023526034 cites W2014706126 @default.
• W2023526034 cites W2029891516 @default.
• W2023526034 cites W2030299753 @default.
• W2023526034 cites W2037597733 @default.
• W2023526034 cites W2040230451 @default.
• W2023526034 cites W2041189121 @default.
• W2023526034 cites W2043322860 @default.
• W2023526034 cites W2052300054 @default.
• W2023526034 cites W2058699296 @default.
• W2023526034 cites W2059394062 @default.
• W2023526034 cites W2059437136 @default.
• W2023526034 cites W2060493806 @default.
• W2023526034 cites W2063092034 @default.
• W2023526034 cites W2063362175 @default.
• W2023526034 cites W2064877498 @default.
• W2023526034 cites W2068920207 @default.
• W2023526034 cites W2073589625 @default.
• W2023526034 cites W2085873705 @default.
• W2023526034 cites W2113448091 @default.
• W2023526034 cites W2120771179 @default.
• W2023526034 cites W2173077573 @default.
• W2023526034 cites W2182251026 @default.
• W2023526034 cites W2213510691 @default.
• W2023526034 cites W2742086875 @default.
• W2023526034 cites W4246961658 @default.
• W2023526034 cites W4252181657 @default.
• W2023526034 cites W4365786654 @default.
• W2023526034 doi "https://doi.org/10.1016/0020-1790(89)90047-4" @default.
• W2023526034 hasPublicationYear "1989" @default.
• W2023526034 type Work @default.
• W2023526034 sameAs 2023526034 @default.
• W2023526034 citedByCount "46" @default.
• W2023526034 countsByYear W20235260342015 @default.
• W2023526034 countsByYear W20235260342018 @default.
• W2023526034 crossrefType "journal-article" @default.
• W2023526034 hasAuthorship W2023526034A5019399185 @default.
• W2023526034 hasAuthorship W2023526034A5049926824 @default.
• W2023526034 hasAuthorship W2023526034A5073392669 @default.
• W2023526034 hasAuthorship W2023526034A5077576317 @default.
• W2023526034 hasAuthorship W2023526034A5091234260 @default.
• W2023526034 hasConcept C107824862 @default.
• W2023526034 hasConcept C124815738 @default.
• W2023526034 hasConcept C12554922 @default.
• W2023526034 hasConcept C170493617 @default.
• W2023526034 hasConcept C185592680 @default.
• W2023526034 hasConcept C18903297 @default.
• W2023526034 hasConcept C2777346155 @default.
• W2023526034 hasConcept C2777367657 @default.
• W2023526034 hasConcept C2779808186 @default.
• W2023526034 hasConcept C2780625307 @default.
• W2023526034 hasConcept C32786932 @default.
• W2023526034 hasConcept C55493867 @default.
• W2023526034 hasConcept C71240020 @default.
• W2023526034 hasConcept C74998103 @default.
• W2023526034 hasConcept C86803240 @default.
• W2023526034 hasConceptScore W2023526034C107824862 @default.
• W2023526034 hasConceptScore W2023526034C124815738 @default.
• W2023526034 hasConceptScore W2023526034C12554922 @default.
• W2023526034 hasConceptScore W2023526034C170493617 @default.
• W2023526034 hasConceptScore W2023526034C185592680 @default.
• W2023526034 hasConceptScore W2023526034C18903297 @default.
• W2023526034 hasConceptScore W2023526034C2777346155 @default.
• W2023526034 hasConceptScore W2023526034C2777367657 @default.
• W2023526034 hasConceptScore W2023526034C2779808186 @default.
• W2023526034 hasConceptScore W2023526034C2780625307 @default.
• W2023526034 hasConceptScore W2023526034C32786932 @default.
• W2023526034 hasConceptScore W2023526034C55493867 @default.
• W2023526034 hasConceptScore W2023526034C71240020 @default.
• W2023526034 hasConceptScore W2023526034C74998103 @default.
• W2023526034 hasConceptScore W2023526034C86803240 @default.
• W2023526034 hasIssue "4" @default.
• W2023526034 hasLocation W20235260341 @default.
• W2023526034 hasOpenAccess W2023526034 @default.
• W2023526034 hasPrimaryLocation W20235260341 @default.
• W2023526034 hasRelatedWork W2023526034 @default.
• W2023526034 hasRelatedWork W2054434273 @default.
• W2023526034 hasRelatedWork W2063362175 @default.

• next