FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023531878> ?p ?o ?g. }

• W2023531878 endingPage "66" @default.
• W2023531878 startingPage "59" @default.
• W2023531878 abstract "Although post-traumatic stress disorder (PTSD) and addiction are very different disorders, both are characterized by hyperreactivity to trauma- or drug-related cues, respectively. We investigated whether an appetitive conditioning task, Pavlovian conditioned approach, which predicts vulnerability to reinstatement of cocaine-seeking, also predicts fear incubation, which may be a marker for vulnerability to PTSD. We classified rats based on whether they learned to approach and interact with a food predictive cue (sign-trackers), or, whether upon cue presentation they went to the location of impending food delivery (goal-trackers). Rats were then exposed to extensive Pavlovian tone-shock pairings, which causes the fear response to increase or incubate over time. We found that the fear incubation effect was only present in sign-trackers. The behavior of goal-trackers was more consistent with a normal fear response-it was most robust immediately after training and decayed slowly over time. Sign-trackers also had lower levels of brain-derived neurotrophic factor (BDNF) protein in the prefrontal cortex than goal-trackers. These results indicate that, while many factors likely contribute to the disproportionate co-occurrence of PTSD and substance abuse, one such factor may be a core psychological trait that biases some individuals to attribute excessive motivational significance to predictive cues, regardless of the emotional valence of those cues. High levels of BDNF in the prefrontal cortex may be protective against developing excessive emotional and motivational responses to salient cues." @default.
• W2023531878 created "2016-06-24" @default.
• W2023531878 creator A5029245318 @default.
• W2023531878 creator A5039619508 @default.
• W2023531878 creator A5040052363 @default.
• W2023531878 creator A5072974295 @default.
• W2023531878 date "2015-01-01" @default.
• W2023531878 modified "2023-10-17" @default.
• W2023531878 title "Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats" @default.
• W2023531878 cites W1512595125 @default.
• W2023531878 cites W1568119668 @default.
• W2023531878 cites W1709379088 @default.
• W2023531878 cites W1726878840 @default.
• W2023531878 cites W1755683523 @default.
• W2023531878 cites W1917605014 @default.
• W2023531878 cites W1964929156 @default.
• W2023531878 cites W1965619360 @default.
• W2023531878 cites W1967625322 @default.
• W2023531878 cites W1969348782 @default.
• W2023531878 cites W1970270646 @default.
• W2023531878 cites W1973925225 @default.
• W2023531878 cites W1976587030 @default.
• W2023531878 cites W1977409271 @default.
• W2023531878 cites W1983090694 @default.
• W2023531878 cites W1984531350 @default.
• W2023531878 cites W1985955524 @default.
• W2023531878 cites W1987959094 @default.
• W2023531878 cites W1988132969 @default.
• W2023531878 cites W1990596248 @default.
• W2023531878 cites W1993348268 @default.
• W2023531878 cites W1997906961 @default.
• W2023531878 cites W1997969083 @default.
• W2023531878 cites W1999948756 @default.
• W2023531878 cites W2005718472 @default.
• W2023531878 cites W2006740509 @default.
• W2023531878 cites W2012269969 @default.
• W2023531878 cites W2015591073 @default.
• W2023531878 cites W2017084137 @default.
• W2023531878 cites W2017966418 @default.
• W2023531878 cites W2029554675 @default.
• W2023531878 cites W2031495645 @default.
• W2023531878 cites W2032781032 @default.
• W2023531878 cites W2035707912 @default.
• W2023531878 cites W2036616369 @default.
• W2023531878 cites W2043780240 @default.
• W2023531878 cites W2047652287 @default.
• W2023531878 cites W2047731623 @default.
• W2023531878 cites W2049468980 @default.
• W2023531878 cites W2051000959 @default.
• W2023531878 cites W2051112054 @default.
• W2023531878 cites W2052214162 @default.
• W2023531878 cites W2057279566 @default.
• W2023531878 cites W2058317145 @default.
• W2023531878 cites W2061211832 @default.
• W2023531878 cites W2063918867 @default.
• W2023531878 cites W2064005268 @default.
• W2023531878 cites W2066577103 @default.
• W2023531878 cites W2071580102 @default.
• W2023531878 cites W2080240638 @default.
• W2023531878 cites W2083414260 @default.
• W2023531878 cites W2085298903 @default.
• W2023531878 cites W2086478621 @default.
• W2023531878 cites W2089083437 @default.
• W2023531878 cites W2092020421 @default.
• W2023531878 cites W2093154691 @default.
• W2023531878 cites W2095283153 @default.
• W2023531878 cites W2101180741 @default.
• W2023531878 cites W2104782678 @default.
• W2023531878 cites W2110474122 @default.
• W2023531878 cites W2112131438 @default.
• W2023531878 cites W2114214919 @default.
• W2023531878 cites W2119246143 @default.
• W2023531878 cites W2123008707 @default.
• W2023531878 cites W2125269228 @default.
• W2023531878 cites W2128859607 @default.
• W2023531878 cites W2138978158 @default.
• W2023531878 cites W2140201388 @default.
• W2023531878 cites W2140594127 @default.
• W2023531878 cites W2159689947 @default.
• W2023531878 cites W2160276478 @default.
• W2023531878 cites W2162074174 @default.
• W2023531878 cites W2164765293 @default.
• W2023531878 cites W2165318854 @default.
• W2023531878 cites W2168861241 @default.
• W2023531878 cites W2179943853 @default.
• W2023531878 cites W2328619022 @default.
• W2023531878 cites W2344117922 @default.
• W2023531878 cites W4239732083 @default.
• W2023531878 cites W4239854769 @default.
• W2023531878 cites W94898649 @default.
• W2023531878 doi "https://doi.org/10.1016/j.bbr.2014.04.002" @default.
• W2023531878 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4201891" @default.
• W2023531878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24747659" @default.
• W2023531878 hasPublicationYear "2015" @default.
• W2023531878 type Work @default.
• W2023531878 sameAs 2023531878 @default.
• W2023531878 citedByCount "41" @default.
• W2023531878 countsByYear W20235318782015 @default.

• next