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- W2023532958 abstract "THE SEARCH for continued refinement in the treatment of germ cell non-seminomatous tumour patients has been emphasised [ 11. Given the high cure rate achieved through the introduction of cisplatin based chemotherapy, reduction of toxicity is a suitable endpoint in patients with good risk disease. The threedrug regimen BEP (bleomycin, etoposide, cisplatin) is the standard treatment for these patients. Because of the associated pulmonary and vascular toxicity, limiting the use of bleomycin has been the objective of several trials. So far, two randomised studies compared the efficacy of cisplatin plus etoposide (El’) with or without bleomycin and led to apparently conflicting results [2, 31. At Indiana University, 178 patients were treated with three cycles of cisplatin (20 mg/m2) plus etoposide (100 mg/m2) both given on days l-5 every 3 weeks, with or without bleomycin (30 IU weekly x 9). The study was suspended early because interim analysis demonstrated a significant (F’ = 0.03) increase in the number of adverse events on EP arm [2]. The second trial was conducted by the EORTC and compared four cycles of cisplatin (20 mg/m2, days 1-5) plus etoposide (120 mg/m2, days 1,3,5) every 3 weeks, with or without bleomycin (30 IU weekly x 12). In a preliminary analysis, the efficacy of both regimens is not significantly different[3]." @default.
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- W2023532958 date "1991-12-01" @default.
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- W2023532958 title "Treatment of good-risk disseminated non-seminomatous germ cell tumours: the less bleomycin, the more cisplatin?" @default.
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- W2023532958 doi "https://doi.org/10.1016/0277-5379(91)90458-p" @default.
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