FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023541645> ?p ?o ?g. }

• W2023541645 abstract "Abstract Introduction and objectives Optimal management for clinical stage I nonseminomatous testicular germ cell tumours (NSGCTs) is still controversial. The main options for standard care surveillance, primary chemotherapy, and nerve-sparing retroperitoneal lymph node dissection (nsRPLND) result in the same high cure rate of close to 100%. It is the purpose to critically review recent developments concerning primary therapy of clinical stage I NSGCT and to identify potential new prognostic risk factors predicting occult metastatic retroperitoneal lymph node disease and enabling an individualized risk-adapted therapeutic approach. Methods Analysis of published full-length papers that were identified with Medline and Cancerlit from January 1987 to January 2006. Paper was structured according the recommendations of the European Germ Cell Cancer Consensus Group (EGCCCG). Results In accordance with the primary goal to improve quality of life, protect fertility, and reduce long-term toxicity in survivors of testis cancer, the major advantage of surveillance protocols is that adjuvant therapy will be administered only to those patients who require therapy. This advantage has to be balanced against a constant psychological threat and a relapse rate of 20–25%, necessitating extensive polychemotherapy and residual tumor resection in 30%. Surveillance is recommended as the treatment of choice for low-risk tumours defined by absence of vascular invasion, 50% embryonal carcinoma, and MIB-1 score >70%; however, the predictive accuracy of these markers is only 60% resulting in a high rate of overtreatment. An advantage of primary chemotherapy is the absence of surgical morbidity; disadvantages are short- and long-term toxicity, lower cure rate of relapses, and potential affect on fertility. Conclusions Surveillance, primary chemotherapy, and primary nsRPLND result in the same high cure rate approaching 100%. Evidence-based recommendations with regard to the potentially best treatment are available but still advantages and disadvantages of all treatment modalities have to be discussed extensively with the patient." @default.
• W2023541645 created "2016-06-24" @default.
• W2023541645 creator A5048118430 @default.
• W2023541645 creator A5073639245 @default.
• W2023541645 date "2006-04-01" @default.
• W2023541645 modified "2023-10-18" @default.
• W2023541645 title "Risk-Adapted Management of Clinical Stage I Nonseminomatous Testicular Germ Cell Tumours" @default.
• W2023541645 cites W118559235 @default.
• W2023541645 cites W1521211182 @default.
• W2023541645 cites W1568651979 @default.
• W2023541645 cites W1583056517 @default.
• W2023541645 cites W1701748062 @default.
• W2023541645 cites W1819187527 @default.
• W2023541645 cites W1866911875 @default.
• W2023541645 cites W1967402406 @default.
• W2023541645 cites W1975694025 @default.
• W2023541645 cites W1980117006 @default.
• W2023541645 cites W1984022458 @default.
• W2023541645 cites W1989541303 @default.
• W2023541645 cites W1989808098 @default.
• W2023541645 cites W1992323517 @default.
• W2023541645 cites W1992946154 @default.
• W2023541645 cites W2001672955 @default.
• W2023541645 cites W2008984621 @default.
• W2023541645 cites W2011049732 @default.
• W2023541645 cites W2025978871 @default.
• W2023541645 cites W2054195011 @default.
• W2023541645 cites W2054724617 @default.
• W2023541645 cites W2062523390 @default.
• W2023541645 cites W2066021065 @default.
• W2023541645 cites W2066089344 @default.
• W2023541645 cites W2067213785 @default.
• W2023541645 cites W2071735132 @default.
• W2023541645 cites W2075494273 @default.
• W2023541645 cites W2085376771 @default.
• W2023541645 cites W2104132159 @default.
• W2023541645 cites W2107548403 @default.
• W2023541645 cites W2108522817 @default.
• W2023541645 cites W2111751851 @default.
• W2023541645 cites W2127265421 @default.
• W2023541645 cites W2129465453 @default.
• W2023541645 cites W2132274239 @default.
• W2023541645 cites W2144119651 @default.
• W2023541645 cites W2163970298 @default.
• W2023541645 cites W2175942611 @default.
• W2023541645 cites W2220613250 @default.
• W2023541645 cites W2264132604 @default.
• W2023541645 cites W2328885593 @default.
• W2023541645 cites W2401469786 @default.
• W2023541645 cites W2405186067 @default.
• W2023541645 doi "https://doi.org/10.1016/j.eursup.2006.02.021" @default.
• W2023541645 hasPublicationYear "2006" @default.
• W2023541645 type Work @default.
• W2023541645 sameAs 2023541645 @default.
• W2023541645 citedByCount "0" @default.
• W2023541645 crossrefType "journal-article" @default.
• W2023541645 hasAuthorship W2023541645A5048118430 @default.
• W2023541645 hasAuthorship W2023541645A5073639245 @default.
• W2023541645 hasConcept C126322002 @default.
• W2023541645 hasConcept C141071460 @default.
• W2023541645 hasConcept C142724271 @default.
• W2023541645 hasConcept C143998085 @default.
• W2023541645 hasConcept C146357865 @default.
• W2023541645 hasConcept C151730666 @default.
• W2023541645 hasConcept C204787440 @default.
• W2023541645 hasConcept C2775862295 @default.
• W2023541645 hasConcept C2776212926 @default.
• W2023541645 hasConcept C2776694085 @default.
• W2023541645 hasConcept C2776938808 @default.
• W2023541645 hasConcept C2779134260 @default.
• W2023541645 hasConcept C2779511695 @default.
• W2023541645 hasConcept C2780849966 @default.
• W2023541645 hasConcept C520017518 @default.
• W2023541645 hasConcept C71924100 @default.
• W2023541645 hasConcept C86803240 @default.
• W2023541645 hasConceptScore W2023541645C126322002 @default.
• W2023541645 hasConceptScore W2023541645C141071460 @default.
• W2023541645 hasConceptScore W2023541645C142724271 @default.
• W2023541645 hasConceptScore W2023541645C143998085 @default.
• W2023541645 hasConceptScore W2023541645C146357865 @default.
• W2023541645 hasConceptScore W2023541645C151730666 @default.
• W2023541645 hasConceptScore W2023541645C204787440 @default.
• W2023541645 hasConceptScore W2023541645C2775862295 @default.
• W2023541645 hasConceptScore W2023541645C2776212926 @default.
• W2023541645 hasConceptScore W2023541645C2776694085 @default.
• W2023541645 hasConceptScore W2023541645C2776938808 @default.
• W2023541645 hasConceptScore W2023541645C2779134260 @default.
• W2023541645 hasConceptScore W2023541645C2779511695 @default.
• W2023541645 hasConceptScore W2023541645C2780849966 @default.
• W2023541645 hasConceptScore W2023541645C520017518 @default.
• W2023541645 hasConceptScore W2023541645C71924100 @default.
• W2023541645 hasConceptScore W2023541645C86803240 @default.
• W2023541645 hasLocation W20235416451 @default.
• W2023541645 hasOpenAccess W2023541645 @default.
• W2023541645 hasPrimaryLocation W20235416451 @default.
• W2023541645 hasRelatedWork W1992229943 @default.
• W2023541645 hasRelatedWork W2021174497 @default.
• W2023541645 hasRelatedWork W2122588453 @default.
• W2023541645 hasRelatedWork W2365806773 @default.
• W2023541645 hasRelatedWork W2405260794 @default.

• next