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• W2023541996 abstract "The authors examined the association between estimated glomerular filtration rate ( eGFR ), calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine‐cystatin C equation, and hemodynamics in 556 normotensive or never‐treated hypertensive patients without kidney disease (mean age, 46 years). Hemodynamic variables were recorded using pulse wave analysis and whole‐body impedance cardiography. The mean e GFR was 98 mL/min/1.73 m 2 (range, 64–145 mL/min/1.73 m 2 and one third of the patients had values below 92, while none had proteinuria. In linear regression analyses adjusted for differences in age, weight:height ratio, low‐density lipoprotein cholesterol, and sex, significant associations were found between lower e GFR and higher systolic ( P =.001) and diastolic blood pressure ( P <.001) and higher systemic vascular resistance ( P =.001). There was no association between e GFR and cardiac output or extracellular volume. In the absence of clinical kidney disease, lower e GFR was associated with higher blood pressure and systemic vascular resistance. Therefore, early impairment in kidney function may be involved in the pathogenesis of essential hypertension." @default.
• W2023541996 created "2016-06-24" @default.
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• W2023541996 date "2014-09-17" @default.
• W2023541996 modified "2023-10-14" @default.
• W2023541996 title "Lower Glomerular Filtration Rate Is Associated With Higher Systemic Vascular Resistance in Patients Without Prevalent Kidney Disease" @default.
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• W2023541996 doi "https://doi.org/10.1111/jch.12405" @default.
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