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- W2023542270 abstract "Lovastatin inhibits a 3-hydroxy 3-methylglutaryl coenzyme A reductase and prevents the synthesis of cholesterol precursors, such as farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), responsible for important cell signaling in cell proliferation and migration. Recently, the anti-cancer effect of lovastatin has been suggested in various tumor types. In this study, we showed that a low dose lovastatin induced senescence and G1 cell cycle arrest in human prostate cancer cells. Addition of GGPP or mevalonate, but not FPP, prevented the lovastatin-induced G1 phase cell cycle arrest and cell senescence. We found that constitutively active RhoA (caRhoA) reversed lovastatin-induced senescence in caRhoA-transfected PC-3 cells. Thus, we postulate that modulation of RhoA may be critical in lovastatin-induced senescence in PC-3 cells." @default.
- W2023542270 created "2016-06-24" @default.
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- W2023542270 date "2006-01-01" @default.
- W2023542270 modified "2023-09-25" @default.
- W2023542270 title "Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells" @default.
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- W2023542270 doi "https://doi.org/10.1016/j.bbrc.2005.11.075" @default.
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