FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023542289> ?p ?o ?g. }

• W2023542289 endingPage "6130" @default.
• W2023542289 startingPage "6125" @default.
• W2023542289 abstract "Exonic splicing enhancer (ESE) sequences are important for the recognition of splice sites in pre-mRNA. These sequences are bound by specific serine-arginine (SR) repeat proteins that promote the assembly of splicing complexes at adjacent splice sites. We have recently identified a splicing coactivator, SRm160/300, which contains SRm160 (the SR nuclear matrix protein of 160 kDa) and a 300-kDa nuclear matrix antigen. In the present study, we show that SRm160/300 is required for a purine-rich ESE to promote the splicing of a pre-mRNA derived from the Drosophila doublesex gene. The association of SRm160/300 and U2 small nuclear ribonucleoprotein particle (snRNP) with this pre-mRNA requires both U1 snRNP and factors bound to the ESE. Independently of pre-mRNA, SRm160/300 specifically interacts with U2 snRNP and with a human homolog of the Drosophila alternative splicing regulator Transformer 2, which binds to purine-rich ESEs. The results suggest a model for ESE function in which the SRm160/300 splicing coactivator promotes critical interactions between ESE-bound activators and the snRNP machinery of the spliceosome." @default.
• W2023542289 created "2016-06-24" @default.
• W2023542289 creator A5022945869 @default.
• W2023542289 creator A5032292978 @default.
• W2023542289 creator A5057680268 @default.
• W2023542289 creator A5087717837 @default.
• W2023542289 date "1999-05-25" @default.
• W2023542289 modified "2023-09-23" @default.
• W2023542289 title "The SRm160/300 splicing coactivator is required for exon-enhancer function" @default.
• W2023542289 cites W1507547708 @default.
• W2023542289 cites W1913039750 @default.
• W2023542289 cites W1964484547 @default.
• W2023542289 cites W1968170811 @default.
• W2023542289 cites W1971956957 @default.
• W2023542289 cites W1973916539 @default.
• W2023542289 cites W1986026506 @default.
• W2023542289 cites W1993243592 @default.
• W2023542289 cites W2008860078 @default.
• W2023542289 cites W2013002081 @default.
• W2023542289 cites W2013955971 @default.
• W2023542289 cites W2014791263 @default.
• W2023542289 cites W2023199595 @default.
• W2023542289 cites W2024267851 @default.
• W2023542289 cites W2034967021 @default.
• W2023542289 cites W2038644462 @default.
• W2023542289 cites W2045340640 @default.
• W2023542289 cites W2054264286 @default.
• W2023542289 cites W2057479447 @default.
• W2023542289 cites W2059669080 @default.
• W2023542289 cites W2060723832 @default.
• W2023542289 cites W2062904165 @default.
• W2023542289 cites W2063225252 @default.
• W2023542289 cites W2076787720 @default.
• W2023542289 cites W2081851185 @default.
• W2023542289 cites W2082491111 @default.
• W2023542289 cites W2085956911 @default.
• W2023542289 cites W2090312831 @default.
• W2023542289 cites W2102337459 @default.
• W2023542289 cites W2104668964 @default.
• W2023542289 cites W2111175132 @default.
• W2023542289 cites W2128614530 @default.
• W2023542289 cites W2136385963 @default.
• W2023542289 cites W2142122497 @default.
• W2023542289 cites W2143889483 @default.
• W2023542289 cites W2165477701 @default.
• W2023542289 cites W48376435 @default.
• W2023542289 cites W2397369086 @default.
• W2023542289 doi "https://doi.org/10.1073/pnas.96.11.6125" @default.
• W2023542289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/26846" @default.
• W2023542289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10339552" @default.
• W2023542289 hasPublicationYear "1999" @default.
• W2023542289 type Work @default.
• W2023542289 sameAs 2023542289 @default.
• W2023542289 citedByCount "81" @default.
• W2023542289 countsByYear W20235422892012 @default.
• W2023542289 countsByYear W20235422892014 @default.
• W2023542289 countsByYear W20235422892015 @default.
• W2023542289 countsByYear W20235422892016 @default.
• W2023542289 countsByYear W20235422892017 @default.
• W2023542289 countsByYear W20235422892018 @default.
• W2023542289 countsByYear W20235422892019 @default.
• W2023542289 countsByYear W20235422892021 @default.
• W2023542289 countsByYear W20235422892022 @default.
• W2023542289 countsByYear W20235422892023 @default.
• W2023542289 crossrefType "journal-article" @default.
• W2023542289 hasAuthorship W2023542289A5022945869 @default.
• W2023542289 hasAuthorship W2023542289A5032292978 @default.
• W2023542289 hasAuthorship W2023542289A5057680268 @default.
• W2023542289 hasAuthorship W2023542289A5087717837 @default.
• W2023542289 hasBestOaLocation W20235422891 @default.
• W2023542289 hasConcept C104317684 @default.
• W2023542289 hasConcept C10447831 @default.
• W2023542289 hasConcept C159194896 @default.
• W2023542289 hasConcept C194583182 @default.
• W2023542289 hasConcept C2908584439 @default.
• W2023542289 hasConcept C36823959 @default.
• W2023542289 hasConcept C40000846 @default.
• W2023542289 hasConcept C42576000 @default.
• W2023542289 hasConcept C54355233 @default.
• W2023542289 hasConcept C54458228 @default.
• W2023542289 hasConcept C67705224 @default.
• W2023542289 hasConcept C68483431 @default.
• W2023542289 hasConcept C73758832 @default.
• W2023542289 hasConcept C75934600 @default.
• W2023542289 hasConcept C77445288 @default.
• W2023542289 hasConcept C86339819 @default.
• W2023542289 hasConcept C86803240 @default.
• W2023542289 hasConcept C94671646 @default.
• W2023542289 hasConcept C95444343 @default.
• W2023542289 hasConceptScore W2023542289C104317684 @default.
• W2023542289 hasConceptScore W2023542289C10447831 @default.
• W2023542289 hasConceptScore W2023542289C159194896 @default.
• W2023542289 hasConceptScore W2023542289C194583182 @default.
• W2023542289 hasConceptScore W2023542289C2908584439 @default.
• W2023542289 hasConceptScore W2023542289C36823959 @default.
• W2023542289 hasConceptScore W2023542289C40000846 @default.
• W2023542289 hasConceptScore W2023542289C42576000 @default.
• W2023542289 hasConceptScore W2023542289C54355233 @default.

• next