Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023542439> ?p ?o ?g. }
- W2023542439 endingPage "109" @default.
- W2023542439 startingPage "104" @default.
- W2023542439 abstract "The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade has been identified as a crucial factor for myogenesis. The STAT3 isoform is essential for satellite cell migration and myogenic differentiation as it mediates the expression of muscle specific myogenic factors. The SOCS (suppressors of cytokine signaling) family of proteins down-regulates STAT activation. Primary human skeletal muscle cells were isolated and cultured to investigate the effect of SOCS3 adenoviral overexpression on myotube maturation. It was demonstrated that STAT3 inhibition did not influence myotube development or survival. Moreover, SOCS3 overexpression enhances the mRNA expression of downstream targets of STAT3, c-FOS and VEGF. These increases were correlated with enhanced mRNA expression of genes associated with muscle maturation and hypertrophy. Thus SOCS3 influences myoblast differentiation and SOCS3 may be significant in regulating the activity of genes previously identified as transcriptionally regulated by STAT3." @default.
- W2023542439 created "2016-06-24" @default.
- W2023542439 creator A5024814922 @default.
- W2023542439 creator A5067222106 @default.
- W2023542439 creator A5084373949 @default.
- W2023542439 date "2011-07-01" @default.
- W2023542439 modified "2023-09-30" @default.
- W2023542439 title "Impact of SOCS3 overexpression on human skeletal muscle development in vitro" @default.
- W2023542439 cites W1537712767 @default.
- W2023542439 cites W1602267436 @default.
- W2023542439 cites W192606375 @default.
- W2023542439 cites W1965464733 @default.
- W2023542439 cites W1972709515 @default.
- W2023542439 cites W1977637861 @default.
- W2023542439 cites W1988242023 @default.
- W2023542439 cites W1992634612 @default.
- W2023542439 cites W1997149085 @default.
- W2023542439 cites W2002131284 @default.
- W2023542439 cites W2005750918 @default.
- W2023542439 cites W2006089941 @default.
- W2023542439 cites W2006090548 @default.
- W2023542439 cites W2007897471 @default.
- W2023542439 cites W2008753856 @default.
- W2023542439 cites W2010764593 @default.
- W2023542439 cites W2017429680 @default.
- W2023542439 cites W2023357069 @default.
- W2023542439 cites W2023360420 @default.
- W2023542439 cites W2024728491 @default.
- W2023542439 cites W2025188362 @default.
- W2023542439 cites W2034540930 @default.
- W2023542439 cites W2036563392 @default.
- W2023542439 cites W2049548558 @default.
- W2023542439 cites W2049819186 @default.
- W2023542439 cites W2050341669 @default.
- W2023542439 cites W2065358818 @default.
- W2023542439 cites W2083802827 @default.
- W2023542439 cites W2093117857 @default.
- W2023542439 cites W2097689258 @default.
- W2023542439 cites W2111670326 @default.
- W2023542439 cites W2115038437 @default.
- W2023542439 cites W2132416790 @default.
- W2023542439 cites W2137312910 @default.
- W2023542439 cites W2139365212 @default.
- W2023542439 cites W2148393398 @default.
- W2023542439 cites W2153188529 @default.
- W2023542439 cites W2163069245 @default.
- W2023542439 cites W2167791620 @default.
- W2023542439 cites W2577649235 @default.
- W2023542439 cites W305551473 @default.
- W2023542439 cites W4255692377 @default.
- W2023542439 doi "https://doi.org/10.1016/j.cyto.2011.03.012" @default.
- W2023542439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21478033" @default.
- W2023542439 hasPublicationYear "2011" @default.
- W2023542439 type Work @default.
- W2023542439 sameAs 2023542439 @default.
- W2023542439 citedByCount "17" @default.
- W2023542439 countsByYear W20235424392012 @default.
- W2023542439 countsByYear W20235424392013 @default.
- W2023542439 countsByYear W20235424392015 @default.
- W2023542439 countsByYear W20235424392016 @default.
- W2023542439 countsByYear W20235424392017 @default.
- W2023542439 countsByYear W20235424392018 @default.
- W2023542439 countsByYear W20235424392019 @default.
- W2023542439 countsByYear W20235424392022 @default.
- W2023542439 countsByYear W20235424392023 @default.
- W2023542439 crossrefType "journal-article" @default.
- W2023542439 hasAuthorship W2023542439A5024814922 @default.
- W2023542439 hasAuthorship W2023542439A5067222106 @default.
- W2023542439 hasAuthorship W2023542439A5084373949 @default.
- W2023542439 hasConcept C104317684 @default.
- W2023542439 hasConcept C112392421 @default.
- W2023542439 hasConcept C126042315 @default.
- W2023542439 hasConcept C134018914 @default.
- W2023542439 hasConcept C157333092 @default.
- W2023542439 hasConcept C171958077 @default.
- W2023542439 hasConcept C207200792 @default.
- W2023542439 hasConcept C2778277574 @default.
- W2023542439 hasConcept C2778923194 @default.
- W2023542439 hasConcept C2779959927 @default.
- W2023542439 hasConcept C3763915 @default.
- W2023542439 hasConcept C42362537 @default.
- W2023542439 hasConcept C54355233 @default.
- W2023542439 hasConcept C62478195 @default.
- W2023542439 hasConcept C65439459 @default.
- W2023542439 hasConcept C86339819 @default.
- W2023542439 hasConcept C86803240 @default.
- W2023542439 hasConcept C95444343 @default.
- W2023542439 hasConceptScore W2023542439C104317684 @default.
- W2023542439 hasConceptScore W2023542439C112392421 @default.
- W2023542439 hasConceptScore W2023542439C126042315 @default.
- W2023542439 hasConceptScore W2023542439C134018914 @default.
- W2023542439 hasConceptScore W2023542439C157333092 @default.
- W2023542439 hasConceptScore W2023542439C171958077 @default.
- W2023542439 hasConceptScore W2023542439C207200792 @default.
- W2023542439 hasConceptScore W2023542439C2778277574 @default.
- W2023542439 hasConceptScore W2023542439C2778923194 @default.
- W2023542439 hasConceptScore W2023542439C2779959927 @default.
- W2023542439 hasConceptScore W2023542439C3763915 @default.