FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023542569> ?p ?o ?g. }

• W2023542569 endingPage "507" @default.
• W2023542569 startingPage "498" @default.
• W2023542569 abstract "Sotalol Plus Quinidine and Torsades de Pointes. Introduction: Clinical treatment with a combination of Class IA and III antiarrhythmic drugs is not recommended, as they both favor bradycardia-dependent proarrhythmic events such as torsades de pointes (TdP). However, this theoretical additive effect on ventricular repolarization has never heen demonstrated and could be questioned as other Class I drugs, such as mexiletine, a Class IB drug, limit the number of sotalol-induced TdP in dogs with AV block, suggesting the possibility of an antagonistic action of Class I properties against Class III effects. Methods and Results: We compared the electrophysiologic and proarrhythmic effects of sotalol (Class III) alone and combined with quiuidine (Class IA) in a canine model of acquired long QT syndrome. Seven hypokalemic (K*: 3 ± 0.1 mEq/L) dogs with chronic AV block had a demand pacemaker implanted and set at a rate of 25 beats/min. They were submitted to two (sotatol-alone and sotalol-plus-quinidine) experiments 48 bours apart usiug a randomized cross-over protocol. They were pretreated with quinidine (10 mg/kg + 1.8 mg/kg per hour) or saline infused throughout the experiment, aud given sotalol (4.5 mg/kg + 1.5 mg/kg per hour) for 2 hours, 30 minutes after the beginning of the pretreatment infusion during both experiments. Ventricular and atrial cycle lengths were similarly increased by sotalol after quinidine or saline. The sotalol-induced prolongation of the QT interval was significantly shorter in quinidine-pretreated dogs (24 ± 7 msec after quinidine vs 40 ± 8 msec after saline). Fewer dogs developed TdP: significantly during the first hour of infusion (1/7 sotalol-plus-quinidine vs 6/7 sotalol-alone dogs, P < 0.05) but nonsignificantly during the second hour (3/7 vs 6/7). Conclusion: In this model, the sotalol-plus-quinidine combination is at least no more arrhythmogenic than either of the drugs given alone." @default.
• W2023542569 created "2016-06-24" @default.
• W2023542569 creator A5000785884 @default.
• W2023542569 creator A5027760129 @default.
• W2023542569 creator A5028759234 @default.
• W2023542569 creator A5029436181 @default.
• W2023542569 creator A5031944753 @default.
• W2023542569 creator A5061762083 @default.
• W2023542569 creator A5069509986 @default.
• W2023542569 date "1998-05-01" @default.
• W2023542569 modified "2023-09-26" @default.
• W2023542569 title "Combination of Sotalol and Quinidine in a Canine Model of Torsades de Pointes." @default.
• W2023542569 cites W1967255964 @default.
• W2023542569 cites W1979233860 @default.
• W2023542569 cites W1984590567 @default.
• W2023542569 cites W1986728006 @default.
• W2023542569 cites W1989468776 @default.
• W2023542569 cites W1995684699 @default.
• W2023542569 cites W2003523118 @default.
• W2023542569 cites W2006757545 @default.
• W2023542569 cites W2007427490 @default.
• W2023542569 cites W2012939008 @default.
• W2023542569 cites W2014167951 @default.
• W2023542569 cites W2018173278 @default.
• W2023542569 cites W2020900154 @default.
• W2023542569 cites W2030815572 @default.
• W2023542569 cites W2033590343 @default.
• W2023542569 cites W2033993037 @default.
• W2023542569 cites W2040355128 @default.
• W2023542569 cites W2040721075 @default.
• W2023542569 cites W2048153917 @default.
• W2023542569 cites W2063000438 @default.
• W2023542569 cites W2063406626 @default.
• W2023542569 cites W2077538762 @default.
• W2023542569 cites W2078505506 @default.
• W2023542569 cites W2080407158 @default.
• W2023542569 cites W2081517567 @default.
• W2023542569 cites W2083397218 @default.
• W2023542569 cites W2085773239 @default.
• W2023542569 cites W2091905179 @default.
• W2023542569 cites W2113205108 @default.
• W2023542569 cites W2131450673 @default.
• W2023542569 cites W2133488495 @default.
• W2023542569 cites W2154728263 @default.
• W2023542569 cites W2299987911 @default.
• W2023542569 cites W2463417997 @default.
• W2023542569 cites W4240492906 @default.
• W2023542569 cites W4242392980 @default.
• W2023542569 cites W4321061813 @default.
• W2023542569 cites W2084165941 @default.
• W2023542569 doi "https://doi.org/10.1111/j.1540-8167.1998.tb01842.x" @default.
• W2023542569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9607458" @default.
• W2023542569 hasPublicationYear "1998" @default.
• W2023542569 type Work @default.
• W2023542569 sameAs 2023542569 @default.
• W2023542569 citedByCount "11" @default.
• W2023542569 countsByYear W20235425692013 @default.
• W2023542569 countsByYear W20235425692018 @default.
• W2023542569 countsByYear W20235425692021 @default.
• W2023542569 crossrefType "journal-article" @default.
• W2023542569 hasAuthorship W2023542569A5000785884 @default.
• W2023542569 hasAuthorship W2023542569A5027760129 @default.
• W2023542569 hasAuthorship W2023542569A5028759234 @default.
• W2023542569 hasAuthorship W2023542569A5029436181 @default.
• W2023542569 hasAuthorship W2023542569A5031944753 @default.
• W2023542569 hasAuthorship W2023542569A5061762083 @default.
• W2023542569 hasAuthorship W2023542569A5069509986 @default.
• W2023542569 hasConcept C118441451 @default.
• W2023542569 hasConcept C126322002 @default.
• W2023542569 hasConcept C164705383 @default.
• W2023542569 hasConcept C2776639339 @default.
• W2023542569 hasConcept C2777008848 @default.
• W2023542569 hasConcept C2777561782 @default.
• W2023542569 hasConcept C2777796741 @default.
• W2023542569 hasConcept C2778131192 @default.
• W2023542569 hasConcept C2779161974 @default.
• W2023542569 hasConcept C2780074459 @default.
• W2023542569 hasConcept C2780339425 @default.
• W2023542569 hasConcept C2780486423 @default.
• W2023542569 hasConcept C42219234 @default.
• W2023542569 hasConcept C71924100 @default.
• W2023542569 hasConceptScore W2023542569C118441451 @default.
• W2023542569 hasConceptScore W2023542569C126322002 @default.
• W2023542569 hasConceptScore W2023542569C164705383 @default.
• W2023542569 hasConceptScore W2023542569C2776639339 @default.
• W2023542569 hasConceptScore W2023542569C2777008848 @default.
• W2023542569 hasConceptScore W2023542569C2777561782 @default.
• W2023542569 hasConceptScore W2023542569C2777796741 @default.
• W2023542569 hasConceptScore W2023542569C2778131192 @default.
• W2023542569 hasConceptScore W2023542569C2779161974 @default.
• W2023542569 hasConceptScore W2023542569C2780074459 @default.
• W2023542569 hasConceptScore W2023542569C2780339425 @default.
• W2023542569 hasConceptScore W2023542569C2780486423 @default.
• W2023542569 hasConceptScore W2023542569C42219234 @default.
• W2023542569 hasConceptScore W2023542569C71924100 @default.
• W2023542569 hasIssue "5" @default.
• W2023542569 hasLocation W20235425691 @default.
• W2023542569 hasLocation W20235425692 @default.

• next