Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023543323> ?p ?o ?g. }
- W2023543323 endingPage "301" @default.
- W2023543323 startingPage "294" @default.
- W2023543323 abstract "The small GTPase Rac regulates neuronal behavior, but whether it also functions in neural progenitor cells has not yet been explored. Here we report that Rac contributes to the regulation of nuclear migration in neocortical progenitor cells. Rac1 is expressed by progenitor cells in a unique spatiotemporal pattern. Cross-sectional immunohistochemical examination revealed intense Rac1 immunoreactivity at the ventricular surface. Similar staining patterns were obtained by immunofluorescence for a Rac-activator, Tiam1, and by reactions to detect the GTP-bound (active) form of Rac. En face inspection of the ventricular surface revealed that apical Rac1 localization was most frequent in M-phase cells, and the endfeet of cells in other cell cycle phases also showed apical Rac1 distribution at lower frequencies. To ask whether progenitor cell behavior prior to and during M phase is Rac-dependent, we monitored individual DiI-labeled progenitor cells live in the presence of a Rac inhibitor, NSC23766. We observed significantly retarded adventricular nuclear migration, as well as cytokinesis failures. Similar inhibitory effects were obtained by forced expression of a dominant-negative Rac1. These results suggest that Rac may play a role in interkinetic nuclear migration in the developing mouse brain." @default.
- W2023543323 created "2016-06-24" @default.
- W2023543323 creator A5011733992 @default.
- W2023543323 creator A5013090856 @default.
- W2023543323 creator A5014619164 @default.
- W2023543323 creator A5022742067 @default.
- W2023543323 creator A5025867348 @default.
- W2023543323 creator A5033048819 @default.
- W2023543323 creator A5038553506 @default.
- W2023543323 creator A5048116353 @default.
- W2023543323 creator A5061957454 @default.
- W2023543323 creator A5080922446 @default.
- W2023543323 creator A5082608212 @default.
- W2023543323 creator A5087909718 @default.
- W2023543323 date "2009-04-01" @default.
- W2023543323 modified "2023-10-06" @default.
- W2023543323 title "Rac is involved in the interkinetic nuclear migration of cortical progenitor cells" @default.
- W2023543323 cites W1499363363 @default.
- W2023543323 cites W1503727145 @default.
- W2023543323 cites W1970574518 @default.
- W2023543323 cites W1977055303 @default.
- W2023543323 cites W1977679299 @default.
- W2023543323 cites W1979895839 @default.
- W2023543323 cites W1983706059 @default.
- W2023543323 cites W1988976106 @default.
- W2023543323 cites W1996824655 @default.
- W2023543323 cites W2006863844 @default.
- W2023543323 cites W2009495925 @default.
- W2023543323 cites W2013466759 @default.
- W2023543323 cites W2013532145 @default.
- W2023543323 cites W2021515035 @default.
- W2023543323 cites W2025868352 @default.
- W2023543323 cites W2033324702 @default.
- W2023543323 cites W2039296434 @default.
- W2023543323 cites W2060645534 @default.
- W2023543323 cites W2062455182 @default.
- W2023543323 cites W2063107522 @default.
- W2023543323 cites W2078451104 @default.
- W2023543323 cites W2078564581 @default.
- W2023543323 cites W2079356305 @default.
- W2023543323 cites W2082574627 @default.
- W2023543323 cites W2084343784 @default.
- W2023543323 cites W2086630567 @default.
- W2023543323 cites W2088814620 @default.
- W2023543323 cites W2093226717 @default.
- W2023543323 cites W2100119912 @default.
- W2023543323 cites W2107806372 @default.
- W2023543323 cites W2111081732 @default.
- W2023543323 cites W2115130933 @default.
- W2023543323 cites W2115238617 @default.
- W2023543323 cites W2121891764 @default.
- W2023543323 cites W2124713665 @default.
- W2023543323 cites W2139074300 @default.
- W2023543323 cites W2142685635 @default.
- W2023543323 cites W2162049443 @default.
- W2023543323 doi "https://doi.org/10.1016/j.neures.2009.01.006" @default.
- W2023543323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19367791" @default.
- W2023543323 hasPublicationYear "2009" @default.
- W2023543323 type Work @default.
- W2023543323 sameAs 2023543323 @default.
- W2023543323 citedByCount "34" @default.
- W2023543323 countsByYear W20235433232012 @default.
- W2023543323 countsByYear W20235433232013 @default.
- W2023543323 countsByYear W20235433232014 @default.
- W2023543323 countsByYear W20235433232015 @default.
- W2023543323 countsByYear W20235433232016 @default.
- W2023543323 countsByYear W20235433232018 @default.
- W2023543323 countsByYear W20235433232019 @default.
- W2023543323 crossrefType "journal-article" @default.
- W2023543323 hasAuthorship W2023543323A5011733992 @default.
- W2023543323 hasAuthorship W2023543323A5013090856 @default.
- W2023543323 hasAuthorship W2023543323A5014619164 @default.
- W2023543323 hasAuthorship W2023543323A5022742067 @default.
- W2023543323 hasAuthorship W2023543323A5025867348 @default.
- W2023543323 hasAuthorship W2023543323A5033048819 @default.
- W2023543323 hasAuthorship W2023543323A5038553506 @default.
- W2023543323 hasAuthorship W2023543323A5048116353 @default.
- W2023543323 hasAuthorship W2023543323A5061957454 @default.
- W2023543323 hasAuthorship W2023543323A5080922446 @default.
- W2023543323 hasAuthorship W2023543323A5082608212 @default.
- W2023543323 hasAuthorship W2023543323A5087909718 @default.
- W2023543323 hasConcept C136834591 @default.
- W2023543323 hasConcept C1491633281 @default.
- W2023543323 hasConcept C15729860 @default.
- W2023543323 hasConcept C201750760 @default.
- W2023543323 hasConcept C2779717556 @default.
- W2023543323 hasConcept C28328180 @default.
- W2023543323 hasConcept C2909331102 @default.
- W2023543323 hasConcept C45472230 @default.
- W2023543323 hasConcept C55493867 @default.
- W2023543323 hasConcept C62478195 @default.
- W2023543323 hasConcept C85813293 @default.
- W2023543323 hasConcept C86803240 @default.
- W2023543323 hasConcept C95444343 @default.
- W2023543323 hasConceptScore W2023543323C136834591 @default.
- W2023543323 hasConceptScore W2023543323C1491633281 @default.
- W2023543323 hasConceptScore W2023543323C15729860 @default.
- W2023543323 hasConceptScore W2023543323C201750760 @default.