FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023546934> ?p ?o ?g. }

• W2023546934 endingPage "e0120616" @default.
• W2023546934 startingPage "e0120616" @default.
• W2023546934 abstract "α-Actinins (ACTNs) are known to crosslink actin filaments at focal adhesions in migrating cells. Among the four isoforms of mammalian ACTNs, ACTN1 and ACTN4 are ubiquitously expressed. Recently, ACTN4 was reported to enhance cancer cell motility, invasion, and metastasis. However, the mechanism by which ACTN4 drives these malignant phenotypes remains unclear. Here, we show that ACTN4, but not ACTN1, induces the formation of immature focal adhesions in DLD-1 cells, leading to the rapid turnover of focal adhesions. Interestingly, zyxin (ZYX) assembly to focal adhesions was markedly decreased in ACTN4-expressing DLD-1 cells, while the recruitment of paxillin (PAX) occurred normally. On the other hand, in ACTN1-expressing DLD-1 cells, PAX and ZYX were normally recruited to focal adhesions, suggesting that ACTN4 specifically impairs focal adhesion maturation by inhibiting the recruitment of ZYX to focal complexes. Using purified recombinant proteins, we found that ZYX binding to ACTN4 was defective under conditions where ZYX binding to ACTN1 was observed. Furthermore, Matrigel invasion of SW480 cells that express high endogenous levels of ACTN4 protein was inhibited by ectopic expression of ACTN1. Altogether, our results suggest that ZYX defective binding to ACTN4, which occupies focal adhesions instead of ACTN1, induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion." @default.
• W2023546934 created "2016-06-24" @default.
• W2023546934 creator A5010968082 @default.
• W2023546934 creator A5017604630 @default.
• W2023546934 creator A5049388697 @default.
• W2023546934 creator A5059559957 @default.
• W2023546934 date "2015-04-10" @default.
• W2023546934 modified "2023-10-16" @default.
• W2023546934 title "α-Actinin-4 Enhances Colorectal Cancer Cell Invasion by Suppressing Focal Adhesion Maturation" @default.
• W2023546934 cites W1501702588 @default.
• W2023546934 cites W1596385135 @default.
• W2023546934 cites W1887623574 @default.
• W2023546934 cites W1970804746 @default.
• W2023546934 cites W1973225594 @default.
• W2023546934 cites W1979038578 @default.
• W2023546934 cites W1985497018 @default.
• W2023546934 cites W2012496083 @default.
• W2023546934 cites W2017613167 @default.
• W2023546934 cites W2018554691 @default.
• W2023546934 cites W2021436229 @default.
• W2023546934 cites W2024161072 @default.
• W2023546934 cites W2030565228 @default.
• W2023546934 cites W2032868540 @default.
• W2023546934 cites W2040980668 @default.
• W2023546934 cites W2044423100 @default.
• W2023546934 cites W2048209624 @default.
• W2023546934 cites W2054767091 @default.
• W2023546934 cites W2056104802 @default.
• W2023546934 cites W2060555169 @default.
• W2023546934 cites W2064463657 @default.
• W2023546934 cites W2067083395 @default.
• W2023546934 cites W2072913808 @default.
• W2023546934 cites W2079149769 @default.
• W2023546934 cites W2079595896 @default.
• W2023546934 cites W2084555208 @default.
• W2023546934 cites W2085725940 @default.
• W2023546934 cites W2085767196 @default.
• W2023546934 cites W2088034173 @default.
• W2023546934 cites W2093428806 @default.
• W2023546934 cites W2093487975 @default.
• W2023546934 cites W2095654814 @default.
• W2023546934 cites W2096915545 @default.
• W2023546934 cites W2100770756 @default.
• W2023546934 cites W2108186885 @default.
• W2023546934 cites W2111719518 @default.
• W2023546934 cites W2112924183 @default.
• W2023546934 cites W2117454449 @default.
• W2023546934 cites W2119521616 @default.
• W2023546934 cites W2135925002 @default.
• W2023546934 cites W2146140843 @default.
• W2023546934 cites W2148921239 @default.
• W2023546934 cites W2149667112 @default.
• W2023546934 cites W2155491141 @default.
• W2023546934 cites W2162664099 @default.
• W2023546934 cites W2322219433 @default.
• W2023546934 cites W3096977082 @default.
• W2023546934 doi "https://doi.org/10.1371/journal.pone.0120616" @default.
• W2023546934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4393021" @default.
• W2023546934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25860875" @default.
• W2023546934 hasPublicationYear "2015" @default.
• W2023546934 type Work @default.
• W2023546934 sameAs 2023546934 @default.
• W2023546934 citedByCount "40" @default.
• W2023546934 countsByYear W20235469342016 @default.
• W2023546934 countsByYear W20235469342017 @default.
• W2023546934 countsByYear W20235469342018 @default.
• W2023546934 countsByYear W20235469342019 @default.
• W2023546934 countsByYear W20235469342020 @default.
• W2023546934 countsByYear W20235469342021 @default.
• W2023546934 countsByYear W20235469342022 @default.
• W2023546934 countsByYear W20235469342023 @default.
• W2023546934 crossrefType "journal-article" @default.
• W2023546934 hasAuthorship W2023546934A5010968082 @default.
• W2023546934 hasAuthorship W2023546934A5017604630 @default.
• W2023546934 hasAuthorship W2023546934A5049388697 @default.
• W2023546934 hasAuthorship W2023546934A5059559957 @default.
• W2023546934 hasBestOaLocation W20235469341 @default.
• W2023546934 hasConcept C104317684 @default.
• W2023546934 hasConcept C108391706 @default.
• W2023546934 hasConcept C116581196 @default.
• W2023546934 hasConcept C11960822 @default.
• W2023546934 hasConcept C1491633281 @default.
• W2023546934 hasConcept C151166631 @default.
• W2023546934 hasConcept C153911025 @default.
• W2023546934 hasConcept C185592680 @default.
• W2023546934 hasConcept C53345823 @default.
• W2023546934 hasConcept C55493867 @default.
• W2023546934 hasConcept C58207958 @default.
• W2023546934 hasConcept C85789140 @default.
• W2023546934 hasConcept C86803240 @default.
• W2023546934 hasConcept C90934575 @default.
• W2023546934 hasConcept C95444343 @default.
• W2023546934 hasConcept C97029542 @default.
• W2023546934 hasConceptScore W2023546934C104317684 @default.
• W2023546934 hasConceptScore W2023546934C108391706 @default.
• W2023546934 hasConceptScore W2023546934C116581196 @default.
• W2023546934 hasConceptScore W2023546934C11960822 @default.
• W2023546934 hasConceptScore W2023546934C1491633281 @default.

• next