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• W2023547255 abstract "By means of agonist and enzyme experiments, the relative importance of endogenous adenosine, adenine nucleotides or other purines as modulators of cholinergic neuroeffector transmission in preparations of guinea-pig ileum muscle has been examined. Adenosine, 2-chloroadenosine, AMP, ADP, ATP and AMPPNP reversibly inhibited contractile responses to transmural stimulation of the guinea-pig ileum longitudinal muscle. 5′-adenylate deaminase dose-dependently antagonized the inhibitory effect of adenosine, AMP, ADP, ATP and AMPPNP, but not that of 2-chloroadenosine. 8-p-sulphophenyltheophylline, adenosine deaminase and 5′-adenylate deaminase enhanced contractile responses to transmural nerve stimulation. Adenosine deaminase and 5′-adenylate deaminase were virtually equiactive whereas 8-p-sulphophenyltheophylline was much more effective, and the theophylline derivative also enhanced contractile responses in preparations pretreated with adenosine deaminase or 5′-adenylate deaminase. Moreover, 8-p-sulphophenyltheophylline abolished the inhibition by dipyridamole, whereas adenosine deaminase and 5′-adenylate deaminase only partly antagonized the inhibitory effect of dipyridamole. Application of 5′-adenylate deaminase did not enhance the nerve-induced contractions in preparations pretreated with adenosine deaminase or a combination of dipyridamole and adenosine deaminase. In conclusion, adenosine deaminase and 5′-adenylate deaminase enhanced the nerve-induced contractions in the ileum, and, since 5′-adenylate deaminase was inactive after pretreatment with adenosine deaminase, this suggests that endogenous adenosine rather than 5′-adenine nucleotides modulated cholinergic neurotransmission in the ileum. However, the adenosine receptor antagonist 8-p-sulphophenyltheophylline was much more effecctive than the enzymes, suggesting that endogenous purines other than both adenosine pr classical 5′-adenine nucleotides were involved in the purine modulation of neurotransmission in ileum muscle." @default.
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• W2023547255 date "1987-09-01" @default.
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• W2023547255 title "On the nature of endogenous purines modulating cholinergic neurotransmission in the guinea-pig ileum" @default.
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• W2023547255 doi "https://doi.org/10.1111/j.1748-1716.1987.tb08199.x" @default.
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