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• W2023549924 startingPage "585" @default.
• W2023549924 abstract "Thyroid hormone is a classical endocrine signaling molecule that regulates a diverse array of physiological processes ranging from energy metabolism to cardiac performance. The active form of thyroid hormone, 3,5,3′-triiodo-l-thyronine or T3, exerts many of its actions through its receptor, the thyroid hormone receptor (TR), of which there are two subtypes for two isoforms: TRα1, TRα2, TRβ1, and TRβ2. Although TR isoforms, with the exception of TRβ2, are expressed in all tissues, they display different patterns of expression in different tissues, giving rise to tissue-specific isoform actions. Currently, several TRβ-selective agonists have been developed; however, TRα-selective agonists have remained elusive. Herein, we report the synthesis and biological evaluation of CO23, the first potent thyromimetic with TRα-specific effects in vitro and in vivo." @default.
• W2023549924 created "2016-06-24" @default.
• W2023549924 creator A5017706607 @default.
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• W2023549924 date "2006-10-01" @default.
• W2023549924 modified "2023-10-04" @default.
• W2023549924 title "Design and Characterization of a Thyroid Hormone Receptor α (TRα)-Specific Agonist" @default.
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• W2023549924 doi "https://doi.org/10.1021/cb600311v" @default.
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