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- W2023552103 abstract "The role of metabotropic glutamate receptors (mGluRs) in long-term potentiation (LTP) has remained controversial. However, it has recently been shown that group I mGluR activation, prior to high frequency stimulation (HFS), can facilitate or `prime' LTP in the area CA1 of the hippocampus. Here we report that, in the dentate gyrus in vitro, activation of both group I and group II mGluRs primes LTP. Control LTP, 60 min after HFS was 145.4±3.6% of control. The group I mGluR agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG, 100 μM), resulted in LTP of 180.1±12.1% of control, which was significantly greater than control LTP (n=4; P<0.05). The group I/II mGluR agonist 1S,3R-1-aminocyclopentate-1,3-dicarboxylic acid (1S,3R-ACPD, 10 μM), and the group II mGluR agonist (2S,3S,4S)-α-(carboxy-cyclopropyl)-glycine (L-CCG-1, 20 μM) also produced LTP that was significantly greater than control LTP (177.7±11.5% and 183.2±9.1% of control respectively; n=5; P<0.05). The group III mGluR agonist l-2-amino-4-phosphonobutyric acid (L-AP4, 20 μM), failed to significantly prime LTP (153.8±5.9% of control; n=5). It also proved difficult to depotentiate the primed LTP. Following low frequency stimulation (LFS), control LTP was reduced to 101.1±3.6% of control, and to 145.0±2.1%, 141.2±14.7% and 134.0±8.7% of control for CHPG, ACPD and L-CCG-1 primed LTP respectively. We conclude that LTP may be primed by mGluR activation in the dentate gyrus and that this priming is mediated through group I and II mGluRs." @default.
- W2023552103 created "2016-06-24" @default.
- W2023552103 creator A5004599362 @default.
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- W2023552103 date "1998-10-01" @default.
- W2023552103 modified "2023-10-04" @default.
- W2023552103 title "Priming of long-term potentiation by prior activation of group I and II metabotropic glutamate receptors in the rat dentate gyrus in vitro" @default.
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- W2023552103 doi "https://doi.org/10.1016/s0006-8993(98)00897-x" @default.
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