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- W2023552423 abstract "Spleen cells from BALB/c mice immunized against a syngeneic SV40-induced tumor, mKSA, prevented specifically the growth of the corresponding tumor in the tumor cell neutralization assay following preincubation for 5 days with mitogenic concentrations of concanavalin A. This reactivity was shown to be T cell dependent, independent of remaining concanavalin A, and was detected at least up to 60 days following in vivo antigenic immunization. A similar reactivity was obtained with mitogenic concentrations of phytohemagglutinin but not with the B-cell mitogen lypopolysaccharide. Since this reactivity was indistinguishable from that obtained upon in vitro secondary antigenic stimulation with SV40-transformed cells, it is suggested that activation of precytotoxic cells against a syngeneic tumor by concanavalin A into cytotoxic cells may be mediated by the same or similar receptors triggered by the stimulating tumor-associated antigens." @default.
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- W2023552423 date "1979-08-01" @default.
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- W2023552423 title "Concanavalin A-mediated in vitro activation of lymphocytes primed against syngeneic SV40-induced tumor-associated antigens in mice into secondary effector cells capable of specifically preventing tumor growth" @default.
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- W2023552423 doi "https://doi.org/10.1016/0008-8749(79)90259-4" @default.
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