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- W2023552718 endingPage "624" @default.
- W2023552718 startingPage "611" @default.
- W2023552718 abstract "Sporadic inclusion body myositis (sIBM) is the most frequently acquired myopathy in patients over 50 years of age. It is imperative that neurologists and rheumatologists recognize this disorder which may, through clinical and pathological similarities, mimic other myopathies, especially polymyositis. Whereas polymyositis responds to immunosuppressant drug therapy, sIBM responds poorly, if at all. Controversy reigns as to whether sIBM is primarily an inflammatory or a degenerative myopathy, the distinction being vitally important in terms of directing research for effective specific therapies. We review here the pros and the cons for the respective hypotheses. A possible scenario, which our experience leads us to favour, is that sIBM may start with inflammation within muscle. The rush of leukocytes attracted by chemokines and cytokines may induce fibre injury and HLA-I overexpression. If the protein degradation systems are overloaded (possibly due to genetic predisposition, particular HLA-I subtypes or ageing), amyloid and other protein deposits may appear within muscle fibres, reinforcing the myopathic process in a vicious circle." @default.
- W2023552718 created "2016-06-24" @default.
- W2023552718 creator A5027640760 @default.
- W2023552718 creator A5044399363 @default.
- W2023552718 creator A5062671029 @default.
- W2023552718 creator A5072004949 @default.
- W2023552718 creator A5072825908 @default.
- W2023552718 creator A5080625220 @default.
- W2023552718 date "2015-01-13" @default.
- W2023552718 modified "2023-10-01" @default.
- W2023552718 title "Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken" @default.
- W2023552718 cites W1523798384 @default.
- W2023552718 cites W1524832052 @default.
- W2023552718 cites W18390328 @default.
- W2023552718 cites W1920901097 @default.
- W2023552718 cites W1938595280 @default.
- W2023552718 cites W1968973215 @default.
- W2023552718 cites W1969099582 @default.
- W2023552718 cites W1970255363 @default.
- W2023552718 cites W1970850123 @default.
- W2023552718 cites W1971604648 @default.
- W2023552718 cites W1972725992 @default.
- W2023552718 cites W1980438889 @default.
- W2023552718 cites W1982754091 @default.
- W2023552718 cites W1984028130 @default.
- W2023552718 cites W1984471989 @default.
- W2023552718 cites W1987807233 @default.
- W2023552718 cites W1988323047 @default.
- W2023552718 cites W1989124659 @default.
- W2023552718 cites W1989468646 @default.
- W2023552718 cites W1989634299 @default.
- W2023552718 cites W1991344675 @default.
- W2023552718 cites W1993611133 @default.
- W2023552718 cites W1993741004 @default.
- W2023552718 cites W1995262612 @default.
- W2023552718 cites W1995588340 @default.
- W2023552718 cites W1996842986 @default.
- W2023552718 cites W2007531447 @default.
- W2023552718 cites W2008800788 @default.
- W2023552718 cites W2009096886 @default.
- W2023552718 cites W2010014535 @default.
- W2023552718 cites W2010188733 @default.
- W2023552718 cites W2010624194 @default.
- W2023552718 cites W2011754116 @default.
- W2023552718 cites W2012164151 @default.
- W2023552718 cites W2014584314 @default.
- W2023552718 cites W2017476077 @default.
- W2023552718 cites W2018447297 @default.
- W2023552718 cites W2019351430 @default.
- W2023552718 cites W2020599475 @default.
- W2023552718 cites W2021242983 @default.
- W2023552718 cites W2024036714 @default.
- W2023552718 cites W2025920010 @default.
- W2023552718 cites W2028224653 @default.
- W2023552718 cites W2028797559 @default.
- W2023552718 cites W203134634 @default.
- W2023552718 cites W2037223188 @default.
- W2023552718 cites W2037988019 @default.
- W2023552718 cites W2038976020 @default.
- W2023552718 cites W2047959473 @default.
- W2023552718 cites W2053569462 @default.
- W2023552718 cites W2055537742 @default.
- W2023552718 cites W2055881964 @default.
- W2023552718 cites W2057434939 @default.
- W2023552718 cites W2060093283 @default.
- W2023552718 cites W2064041290 @default.
- W2023552718 cites W2064177679 @default.
- W2023552718 cites W2068213079 @default.
- W2023552718 cites W2069449546 @default.
- W2023552718 cites W2069778637 @default.
- W2023552718 cites W2072335655 @default.
- W2023552718 cites W2074203661 @default.
- W2023552718 cites W2079738834 @default.
- W2023552718 cites W2082829109 @default.
- W2023552718 cites W2084861994 @default.
- W2023552718 cites W2086163974 @default.
- W2023552718 cites W2094519193 @default.
- W2023552718 cites W2097831806 @default.
- W2023552718 cites W2099882182 @default.
- W2023552718 cites W2100325546 @default.
- W2023552718 cites W2103252821 @default.
- W2023552718 cites W2105258856 @default.
- W2023552718 cites W2105723190 @default.
- W2023552718 cites W2112508236 @default.
- W2023552718 cites W2114197108 @default.
- W2023552718 cites W2114222452 @default.
- W2023552718 cites W2114795284 @default.
- W2023552718 cites W2117279697 @default.
- W2023552718 cites W2134406320 @default.
- W2023552718 cites W2137208180 @default.
- W2023552718 cites W2137686155 @default.
- W2023552718 cites W2139128868 @default.
- W2023552718 cites W2139140111 @default.
- W2023552718 cites W2139452287 @default.
- W2023552718 cites W2143952074 @default.
- W2023552718 cites W2144067978 @default.
- W2023552718 cites W2144385565 @default.
- W2023552718 cites W2147652122 @default.