Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023552812> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2023552812 endingPage "119" @default.
- W2023552812 startingPage "114" @default.
- W2023552812 abstract "An in vitro/in vivo study was carried out with different rectal formulations of temazepam. Pharmacokinetic data were determined in a cross-over study in 10 volunteers after rectal administration of 10 mg temazepam as a polyethylene glycol based suppository (selected from in vitro data), a liquid-filled capsule and a micro-enema respectively, using oral administration of a liquid-filled capsule as a reference. Serum levels of temazepam indicate an instantaneous and complete release from the micro-enema (Frel=0.94±0.21, Cmax 205±36.9 μg/l, tmax 0.49±0.31 hour) and a slower but complete release of temazepam from the suppository (Frel=1.01±0.25, Cmax 202±41.3 μg/l, tmax 1.48±0.41 hour). A high interindividual variation in absorption profiles was observed after rectal administration of the liquid-filled capsule (Frel 0.72±0.36, Cmax 182±122 μg/l, tmax 4.08±4.28 hour), which makes it less suitable for rectal use. The micro-enema and suppository appear to be useful as rectal formulations for temazepam." @default.
- W2023552812 created "2016-06-24" @default.
- W2023552812 creator A5001527521 @default.
- W2023552812 creator A5087424653 @default.
- W2023552812 date "1996-06-01" @default.
- W2023552812 modified "2023-09-24" @default.
- W2023552812 title "Pharmacokinetic aspects of rectal formulations of Temazepam" @default.
- W2023552812 cites W2023565062 @default.
- W2023552812 cites W2046551021 @default.
- W2023552812 cites W2055164994 @default.
- W2023552812 cites W2060008915 @default.
- W2023552812 cites W2416509281 @default.
- W2023552812 doi "https://doi.org/10.1007/bf00417760" @default.
- W2023552812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8826537" @default.
- W2023552812 hasPublicationYear "1996" @default.
- W2023552812 type Work @default.
- W2023552812 sameAs 2023552812 @default.
- W2023552812 citedByCount "8" @default.
- W2023552812 countsByYear W20235528122015 @default.
- W2023552812 countsByYear W20235528122020 @default.
- W2023552812 countsByYear W20235528122023 @default.
- W2023552812 crossrefType "journal-article" @default.
- W2023552812 hasAuthorship W2023552812A5001527521 @default.
- W2023552812 hasAuthorship W2023552812A5087424653 @default.
- W2023552812 hasBestOaLocation W20235528122 @default.
- W2023552812 hasConcept C112705442 @default.
- W2023552812 hasConcept C126322002 @default.
- W2023552812 hasConcept C170493617 @default.
- W2023552812 hasConcept C22979827 @default.
- W2023552812 hasConcept C2776873419 @default.
- W2023552812 hasConcept C2777056448 @default.
- W2023552812 hasConcept C2778042862 @default.
- W2023552812 hasConcept C2778173252 @default.
- W2023552812 hasConcept C2778778583 @default.
- W2023552812 hasConcept C2781006864 @default.
- W2023552812 hasConcept C59822182 @default.
- W2023552812 hasConcept C71924100 @default.
- W2023552812 hasConcept C86803240 @default.
- W2023552812 hasConcept C98274493 @default.
- W2023552812 hasConceptScore W2023552812C112705442 @default.
- W2023552812 hasConceptScore W2023552812C126322002 @default.
- W2023552812 hasConceptScore W2023552812C170493617 @default.
- W2023552812 hasConceptScore W2023552812C22979827 @default.
- W2023552812 hasConceptScore W2023552812C2776873419 @default.
- W2023552812 hasConceptScore W2023552812C2777056448 @default.
- W2023552812 hasConceptScore W2023552812C2778042862 @default.
- W2023552812 hasConceptScore W2023552812C2778173252 @default.
- W2023552812 hasConceptScore W2023552812C2778778583 @default.
- W2023552812 hasConceptScore W2023552812C2781006864 @default.
- W2023552812 hasConceptScore W2023552812C59822182 @default.
- W2023552812 hasConceptScore W2023552812C71924100 @default.
- W2023552812 hasConceptScore W2023552812C86803240 @default.
- W2023552812 hasConceptScore W2023552812C98274493 @default.
- W2023552812 hasIssue "3" @default.
- W2023552812 hasLocation W20235528121 @default.
- W2023552812 hasLocation W20235528122 @default.
- W2023552812 hasLocation W20235528123 @default.
- W2023552812 hasOpenAccess W2023552812 @default.
- W2023552812 hasPrimaryLocation W20235528121 @default.
- W2023552812 hasRelatedWork W168887325 @default.
- W2023552812 hasRelatedWork W2023552812 @default.
- W2023552812 hasRelatedWork W2050947181 @default.
- W2023552812 hasRelatedWork W2129117661 @default.
- W2023552812 hasRelatedWork W2329970845 @default.
- W2023552812 hasRelatedWork W2362835286 @default.
- W2023552812 hasRelatedWork W2412538019 @default.
- W2023552812 hasRelatedWork W2442273492 @default.
- W2023552812 hasRelatedWork W3231819 @default.
- W2023552812 hasRelatedWork W97816881 @default.
- W2023552812 hasVolume "18" @default.
- W2023552812 isParatext "false" @default.
- W2023552812 isRetracted "false" @default.
- W2023552812 magId "2023552812" @default.
- W2023552812 workType "article" @default.