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• W2023552937 endingPage "5674" @default.
• W2023552937 startingPage "5670" @default.
• W2023552937 abstract "Transcription of the rat growth hormone (rGH) gene in pituitary cells is increased by addition of thyroid hormone (T3). This induction is dependent on the presence of specific sequences just upstream of the rGH promoter. We have partially purified T3 receptor from rat liver and examined its interaction with these rGH sequences. We show here that T3 receptor binds specifically to a site just upstream of the basal rGH promoter. This binding site includes two copies of a 7-base-pair direct repeat, the centers of which are separated by 10 base pairs. Deletions that specifically remove the T3 receptor binding site drastically reduce response to T3 in transient transfection experiments. These results demonstrate that T3 receptor can recognize specific DNA sequences and suggest that it can act directly as a positive transcriptional regulatory factor." @default.
• W2023552937 created "2016-06-24" @default.
• W2023552937 creator A5045758821 @default.
• W2023552937 creator A5049222616 @default.
• W2023552937 creator A5051809645 @default.
• W2023552937 creator A5086674835 @default.
• W2023552937 creator A5088948001 @default.
• W2023552937 date "1987-08-01" @default.
• W2023552937 modified "2023-10-15" @default.
• W2023552937 title "Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone." @default.
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• W2023552937 doi "https://doi.org/10.1073/pnas.84.16.5670" @default.
• W2023552937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/298924" @default.
• W2023552937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3475698" @default.
• W2023552937 hasPublicationYear "1987" @default.
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