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- W2023553755 abstract "Optimization of the cardiovascular system under conditions of long term space flight is provided by individual changes of autonomic cardiovascular control. Heart rate variability (HRV) analysis is an easy to use method under these extreme conditions. We tested the hypothesis that individual HRV analysis provides important information for crew health monitoring. HRV data from 14 Russian cosmonauts measured during long term space flights are presented (two times before and after flight, monthly in flight). HRV characteristics in the time and in the frequency domain were calculated. Predefined discriminant function equations obtained in reference groups (L1=−0.112⁎HR−1.006⁎SI−0.047⁎pNN50−0.086⁎HF; L2=0.140⁎HR−0.165⁎SI−1.293⁎pNN50+0.623⁎HF) were used to define four functional states. (1) Physiological normal, (2) prenosological, (3) premorbid and (4) pathological. Geometric mean values for the ISS cosmonauts based on L1 and L2 remained within normal ranges. A shift from the physiological normal state to the prenosological functional state during space flight was detected. The functional state assessed by HRV improved during space flight if compared to pre-flight and early post-flight functional states. Analysis of individual cosmonauts showed distinct patterns depending on the pre-flight functional state. Using the developed classification a transition process from the state of physiological normal into a prenosological state or premorbid state during different stages of space flight can be detected for individual Russian cosmonauts. Our approach to an estimation of HR regulatory pattern can be useful for prognostic purposes." @default.
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- W2023553755 date "2011-12-01" @default.
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- W2023553755 title "Assessment of individual adaptation to microgravity during long term space flight based on stepwise discriminant analysis of heart rate variability parameters" @default.
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- W2023553755 doi "https://doi.org/10.1016/j.actaastro.2011.07.011" @default.
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