FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023554420> ?p ?o ?g. }

• W2023554420 endingPage "79" @default.
• W2023554420 startingPage "67" @default.
• W2023554420 abstract "This review discusses the hypothesis that mitochondrial dysfunction plays a role in the pathogenesis of the most common form of diabetes, type II diabetes mellitus. Mitochondrial mutations have been linked to the development of diabetes mellitus as part of several rare syndromes, accounting for approximately 1.5% of all cases of the disease (“classic” mitochondrial diabetes). The characteristics of classic mitochondrial diabetes are intermediate between those of type I and type II diabetes, more closely resembling the latter. By studying the biochemical, cellular, and physiologic consequences of mitochondrial DNA mutations that cause classic mitochondrial diabetes, we may also gain important insights into the pathogenesis of type II diabetes mellitus. Individuals with classic mitochondrial diabetes exhibit a variety of defects in mitochondrial electron transfer enzyme activities. Complex I and Complex IV activities in skeletal muscle are almost universally decreased in mitochondrial diabetics compared with control individuals. The major physiologic abnormality in classic mitochondrial diabetes is delayed and insufficient insulin secretion in response to a glucose load. Insulin resistance is less commonly observed in these patients. The link between mitochondrial function and insulin secretion is supported by cellular studies in which introduction of inhibitors of oxidative phosphorylation or depletion of mitochondrial DNA markedly impairs glucose mediated insulin secretion from pancreatic β-cells. Evidence for mitochondrial dysfunction in the common form of type II diabetes includes excessive free radical levels in the plasma of diabetics, increased reactive oxygen species, and decreased ATP synthase activity in cybrids constructed from mitochondria of diabetic patients, and maternal inheritance of the disease. By using the occurrence of diabetes in rare mitochondrial syndromes as an example, evidence supporting a relationship between mitochondrial dysfunction and the common form of type II diabetes is discussed. Mitochondrial function may represent a novel area for the development of therapeutic and diagnostic strategies for type II diabetes mellitus. Drug Dev. Res. 46:67–79, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2023554420 created "2016-06-24" @default.
• W2023554420 creator A5077880056 @default.
• W2023554420 date "1999-01-01" @default.
• W2023554420 modified "2023-09-23" @default.
• W2023554420 title "Mitochondrial dysfunction in diabetes mellitus" @default.
• W2023554420 cites W1543532453 @default.
• W2023554420 cites W1571542070 @default.
• W2023554420 cites W1584374592 @default.
• W2023554420 cites W1737157464 @default.
• W2023554420 cites W1796459452 @default.
• W2023554420 cites W1892902405 @default.
• W2023554420 cites W1894223650 @default.
• W2023554420 cites W1927992628 @default.
• W2023554420 cites W1953115230 @default.
• W2023554420 cites W1967683528 @default.
• W2023554420 cites W1973299612 @default.
• W2023554420 cites W1974404138 @default.
• W2023554420 cites W1974952325 @default.
• W2023554420 cites W1975535652 @default.
• W2023554420 cites W1983856769 @default.
• W2023554420 cites W1985753071 @default.
• W2023554420 cites W1988276497 @default.
• W2023554420 cites W1988939685 @default.
• W2023554420 cites W1996649880 @default.
• W2023554420 cites W1998650120 @default.
• W2023554420 cites W1998877913 @default.
• W2023554420 cites W1999017977 @default.
• W2023554420 cites W2001426290 @default.
• W2023554420 cites W2004577232 @default.
• W2023554420 cites W2010290591 @default.
• W2023554420 cites W2011383364 @default.
• W2023554420 cites W2013548323 @default.
• W2023554420 cites W2018185503 @default.
• W2023554420 cites W2019092328 @default.
• W2023554420 cites W2020579285 @default.
• W2023554420 cites W2021925516 @default.
• W2023554420 cites W2026408975 @default.
• W2023554420 cites W2028834965 @default.
• W2023554420 cites W2033927340 @default.
• W2023554420 cites W2034680854 @default.
• W2023554420 cites W2036140173 @default.
• W2023554420 cites W2036947502 @default.
• W2023554420 cites W2037204981 @default.
• W2023554420 cites W2037880185 @default.
• W2023554420 cites W2039521692 @default.
• W2023554420 cites W2050051162 @default.
• W2023554420 cites W2050808400 @default.
• W2023554420 cites W2051690136 @default.
• W2023554420 cites W2053141759 @default.
• W2023554420 cites W2053192349 @default.
• W2023554420 cites W2054636900 @default.
• W2023554420 cites W2055754613 @default.
• W2023554420 cites W2057209896 @default.
• W2023554420 cites W2059901865 @default.
• W2023554420 cites W2063188685 @default.
• W2023554420 cites W2063873651 @default.
• W2023554420 cites W2068466003 @default.
• W2023554420 cites W2069844549 @default.
• W2023554420 cites W2071756646 @default.
• W2023554420 cites W2078479092 @default.
• W2023554420 cites W2091379604 @default.
• W2023554420 cites W2091945543 @default.
• W2023554420 cites W2092505879 @default.
• W2023554420 cites W2093187370 @default.
• W2023554420 cites W2100968639 @default.
• W2023554420 cites W2102254551 @default.
• W2023554420 cites W2104560553 @default.
• W2023554420 cites W2107270862 @default.
• W2023554420 cites W2107955212 @default.
• W2023554420 cites W2109291482 @default.
• W2023554420 cites W2110279904 @default.
• W2023554420 cites W2112602362 @default.
• W2023554420 cites W2113754802 @default.
• W2023554420 cites W2115337518 @default.
• W2023554420 cites W2119833136 @default.
• W2023554420 cites W2124755022 @default.
• W2023554420 cites W2126835430 @default.
• W2023554420 cites W2131783890 @default.
• W2023554420 cites W2136029366 @default.
• W2023554420 cites W2137675911 @default.
• W2023554420 cites W2142334358 @default.
• W2023554420 cites W2145242451 @default.
• W2023554420 cites W2159087808 @default.
• W2023554420 cites W2159479663 @default.
• W2023554420 cites W2161641259 @default.
• W2023554420 cites W2174978286 @default.
• W2023554420 cites W2178375292 @default.
• W2023554420 cites W2247538616 @default.
• W2023554420 cites W2317132194 @default.
• W2023554420 cites W4212888272 @default.
• W2023554420 cites W4244588350 @default.
• W2023554420 doi "https://doi.org/10.1002/(sici)1098-2299(199901)46:1<67::aid-ddr10>3.0.co;2-v" @default.
• W2023554420 hasPublicationYear "1999" @default.
• W2023554420 type Work @default.
• W2023554420 sameAs 2023554420 @default.
• W2023554420 citedByCount "15" @default.
• W2023554420 countsByYear W20235544202012 @default.

• next