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- W2023555577 abstract "Mutations in the tumour suppressor gene TP53 occur in about 30% of breast cancers. We have used the IARC TP53 mutation database to analyse the pattern of mutations in breast cancers (1392 mutations). The global pattern of mutations is similar to the one of most other cancers, but there is an excess of transversions on G bases in tumours from Western (USA and Europe) as compared to Eastern (Japan) countries. Moreover, the patterns of inherited TP53 mutations associated with breast cancer, differ from those of somatic mutations. These differences support the hypothesis that a fraction of breast cancer mutations occur as a consequence of environmental exposures." @default.
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- W2023555577 date "2001-10-01" @default.
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- W2023555577 title "TP53 mutation patterns in breast cancers: searching for clues of environmental carcinogenesis" @default.
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- W2023555577 doi "https://doi.org/10.1006/scbi.2001.0390" @default.
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