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• W2023555623 abstract "Cyanoguanidine derivatives of loratadine (3a-i) were synthesized and screened for antitumor and anti-inflammatory activity. The most promising compound 3c (R=n-C(8)H(17)) possessed at least twofold higher in vitro cytotoxicity than 5-fluorouracil against mammary (MCF-7 and MDA-MB 231) as well as colon (HT-29) carcinoma cells. The mode of action, however, is so far unclear. The participation of the COX-1/2 enzymes on the cytotoxicity, however, is very unlikely. Nevertheless all compounds showed stronger in vivo anti-inflammatory activity than ibuprofen in the xylene-induced ear swelling assay in mice." @default.
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• W2023555623 date "2012-10-01" @default.
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• W2023555623 title "Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine" @default.
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• W2023555623 doi "https://doi.org/10.1016/j.bmcl.2012.08.041" @default.
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