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- W2023557681 abstract "Plasma amantadine concentrations were assessed in a series of hospitalized schizophrenic patients receiving this drug during a double-blind trial of amantadine and benztropine in the treatment of neuroleptic-induced extrapyramidal symptoms (EPS). Mean (+/- S.E.) plasma amantadine concentrations were 0.54 +/- 0.08 microgram/ml on day 7 and 0.43 +/- 0.08 microgram/ml on day 14. Overall improvement of EPS was not correlated with plasma level, but improvement in the target EPS of rigidity was correlated with plasma amantadine concentration on day 7 (r = 0.75) and day 14 (r = 0.68). There was no evidence that the overall improvement in schizophrenic symptomatology was influenced by plasma amantadine concentrations." @default.
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- W2023557681 date "1977-11-12" @default.
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- W2023557681 title "Pharmacokinetics and Clinical Effects of Amantadine in Drug-Induced Extrapyramidal Symptoms" @default.
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- W2023557681 doi "https://doi.org/10.1002/j.1552-4604.1977.tb01545.x" @default.
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