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- W2023558448 abstract "Polymorphonuclear leucocytes of patients with untreated Crohn9s disease showed a lower level of oxidative metabolism than polymorphonuclear leucocytes of treated Crohn9s disease patients and controls. Whereas the production of superoxide anion (O-.2) in Crohn9s disease patients was almost normal, polymorphonuclear leucocytes of untreated Crohn9s disease patients showed a significantly deficient production of hydrogen peroxide (H2O2). In the medically treated Crohn9s disease patients, a significant negative correlation was found between H2O2 production by polymorphonuclear leucocytes and disease activity. These findings suggest an intrinsic cellular defect in the neutrophils of Crohn9s disease patients which, together with the decreased locomotor function of these cells in vivo, might contribute to the pathogenesis of the chronic inflammation and granuloma formation in this disease." @default.
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- W2023558448 date "1984-08-01" @default.
- W2023558448 modified "2023-10-09" @default.
- W2023558448 title "Partial defect of neutrophil oxidative metabolism in Crohn's disease." @default.
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- W2023558448 doi "https://doi.org/10.1136/gut.25.8.849" @default.
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