Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023558901> ?p ?o ?g. }
- W2023558901 endingPage "552" @default.
- W2023558901 startingPage "543" @default.
- W2023558901 abstract "Asthma has a high prevalence worldwide, and contributes significantly to the socioeconomic burden. According to a classical paradigm, asthma symptoms are attributable to an allergic, Th2-driven airway inflammation that causes airway hyperresponsiveness and results in reversible airway obstruction. Diagnosis and therapy are based mainly on these pathophysiologic concepts. However, these have increasingly been challenged by findings of recent studies, and the frequently observed failure in controlling asthma symptoms. Important recent findings are the protective farm effect in children, the possible prenatal mechanisms of this protection, the recognition of many different asthma phenotypes in children and adults, and the partly disappointing clinical effects of new targeted therapeutic approaches. Systems biology approaches may lead to a more comprehensive view of asthma pathophysiology and a higher success rate of new therapies. Systems biology integrates clinical and experimental data by means of bioinformatics and mathematical modeling. In general, the -omics approach, and the mathematical modeling approach can be described. Recently, several consortia have been attempting to bring together clinical and molecular data from large asthma cohorts, using novel experimental setups, biostatistics, bioinformatics, and mathematical modeling. This systems medicine approach to asthma will help address the different asthma phenotypes with adequate therapy and possibly preventive strategies." @default.
- W2023558901 created "2016-06-24" @default.
- W2023558901 creator A5009438254 @default.
- W2023558901 creator A5010224302 @default.
- W2023558901 creator A5019841125 @default.
- W2023558901 creator A5067743298 @default.
- W2023558901 date "2013-01-11" @default.
- W2023558901 modified "2023-09-25" @default.
- W2023558901 title "Asthma phenotyping, therapy, and prevention: what can we learn from systems biology?" @default.
- W2023558901 cites W1504379507 @default.
- W2023558901 cites W1518209041 @default.
- W2023558901 cites W1553889001 @default.
- W2023558901 cites W1641228030 @default.
- W2023558901 cites W174675126 @default.
- W2023558901 cites W1846706131 @default.
- W2023558901 cites W1879339110 @default.
- W2023558901 cites W1894142702 @default.
- W2023558901 cites W1910445189 @default.
- W2023558901 cites W1916962812 @default.
- W2023558901 cites W1967718221 @default.
- W2023558901 cites W1968363067 @default.
- W2023558901 cites W1970648068 @default.
- W2023558901 cites W1976639879 @default.
- W2023558901 cites W1977164923 @default.
- W2023558901 cites W1984218702 @default.
- W2023558901 cites W1988758075 @default.
- W2023558901 cites W1996731121 @default.
- W2023558901 cites W1997492312 @default.
- W2023558901 cites W1998463022 @default.
- W2023558901 cites W2000869878 @default.
- W2023558901 cites W2005844746 @default.
- W2023558901 cites W2008945707 @default.
- W2023558901 cites W2009540187 @default.
- W2023558901 cites W2013105339 @default.
- W2023558901 cites W2022579693 @default.
- W2023558901 cites W2029819700 @default.
- W2023558901 cites W2032096424 @default.
- W2023558901 cites W2035672333 @default.
- W2023558901 cites W2035831689 @default.
- W2023558901 cites W2036309095 @default.
- W2023558901 cites W2038593924 @default.
- W2023558901 cites W2039051609 @default.
- W2023558901 cites W2039591446 @default.
- W2023558901 cites W2040870202 @default.
- W2023558901 cites W2044763085 @default.
- W2023558901 cites W2046924717 @default.
- W2023558901 cites W2053798956 @default.
- W2023558901 cites W2055548598 @default.
- W2023558901 cites W2057821639 @default.
- W2023558901 cites W2062918919 @default.
- W2023558901 cites W2063968341 @default.
- W2023558901 cites W2072066004 @default.
- W2023558901 cites W2074019022 @default.
- W2023558901 cites W2074921519 @default.
- W2023558901 cites W2078602536 @default.
- W2023558901 cites W2081375496 @default.
- W2023558901 cites W2087384197 @default.
- W2023558901 cites W2089827120 @default.
- W2023558901 cites W2098296430 @default.
- W2023558901 cites W2098450096 @default.
- W2023558901 cites W2105345374 @default.
- W2023558901 cites W2106715003 @default.
- W2023558901 cites W2108919922 @default.
- W2023558901 cites W2109963121 @default.
- W2023558901 cites W2110882251 @default.
- W2023558901 cites W2111852929 @default.
- W2023558901 cites W2113051109 @default.
- W2023558901 cites W2116519763 @default.
- W2023558901 cites W2117480080 @default.
- W2023558901 cites W2117649440 @default.
- W2023558901 cites W2119313166 @default.
- W2023558901 cites W2120294390 @default.
- W2023558901 cites W212077183 @default.
- W2023558901 cites W2122027002 @default.
- W2023558901 cites W2122251865 @default.
- W2023558901 cites W2124283091 @default.
- W2023558901 cites W2124481948 @default.
- W2023558901 cites W2125937596 @default.
- W2023558901 cites W2127482775 @default.
- W2023558901 cites W2128985829 @default.
- W2023558901 cites W2129129511 @default.
- W2023558901 cites W2129550988 @default.
- W2023558901 cites W2131905315 @default.
- W2023558901 cites W2132333593 @default.
- W2023558901 cites W2137554391 @default.
- W2023558901 cites W2141494492 @default.
- W2023558901 cites W2141672817 @default.
- W2023558901 cites W2141724917 @default.
- W2023558901 cites W2146852572 @default.
- W2023558901 cites W2147454451 @default.
- W2023558901 cites W2148171777 @default.
- W2023558901 cites W2149686080 @default.
- W2023558901 cites W2150035260 @default.
- W2023558901 cites W2152259491 @default.
- W2023558901 cites W2155581161 @default.
- W2023558901 cites W2161853794 @default.
- W2023558901 cites W2170599998 @default.
- W2023558901 cites W2170711652 @default.